Results 81 to 90 of about 8,270 (191)

Cholesterol Depletion Delocalizes Phosphatidylinositol Bisphosphate and Inhibits Hormone-stimulated Phosphatidylinositol Turnover [PDF]

Journal of Biological Chemistry, 1998
Caveolae and detergent-insoluble, glycosphingolipid-enriched domains (DIGs) are cholesterol-enriched membrane domains that have been implicated in signal transduction because a variety of signaling proteins as well as phosphatidylinositol bisphosphate (PtdInsP2) are compartmentalized in these domains.
L J, Pike, J M, Miller
openaire   +2 more sources

Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption-ionization-mass spectrometry imaging (MALDI-MSI). [PDF]

, 2018
Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to identify lipids directly involved as potential biomarkers ...
Amen, Beldon, Cajka, Choi, Evans, Fernandis, Gosain, Guest, Guo, Jiang, Koh, Korting, Larjava, McDaniel, Morgan, Nagai, Sasso, Schwamborn, Sen, Stephenson, Thomsen, Tsuji, Yang, Yin   +23 more
core   +2 more sources

Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase [PDF]

Biochemical Journal, 1979
The hydrolysis of membrane-bound phosphatidylinositol in rat liver microsomal fraction by the soluble phosphatidylinositol phosphodiesterase from rat brain was markedly stimulated by oleic acid or arachidonic acid. The stimulation did not require added calcium, although it was abolished by EDTA.
R F, Irvine, A J, Letcher, R M, Dawson
openaire   +2 more sources

Plasma Lipid Profiling of Three Types of Drug-Induced Liver Injury in Japanese Patients: A Preliminary Study

Metabolites, 2020
Drug-induced liver injury (DILI) is a major adverse event caused by drug treatment, which can be categorized into three types: hepatocellular, mixed, and cholestatic.
Kosuke Saito, Tatehiro Kagawa, Keiji Tsuji, Yuji Kumagai, Ken Sato, Shotaro Sakisaka, Naoya Sakamoto, Mitsuhiko Aiso, Shunji Hirose, Nami Mori, Rieko Tanaka, Toshio Uraoka, Kazuhide Takata, Koji Ogawa, Kazuhiko Mori, Motonobu Sato, Takayoshi Nishiya, Kazuhiko Takamatsu, Noriaki Arakawa, Takashi Izumi, Yasuo Ohno, Yoshiro Saito, Hajime Takikawa   +22 more
doaj   +1 more source

The Apicomplexa-specific glucosamine-6-phosphate N-acetyltransferase gene family encodes a key enzyme for glycoconjugate synthesis with potential as therapeutic target [PDF]

, 2018
Apicomplexa form a phylum of obligate parasitic protozoa of great clinical and veterinary importance. These parasites synthesize glycoconjugates for their survival and infectivity, but the enzymatic ...
Artigas Jerónimo, Sara, Bandini, Giulia, Carretero Paulet, Lorenzo, Cova, Marta, González Díaz, Aida, Izquierdo Lázaro, Luis, López Gutiérrez, Borja, Maere, Steven   +7 more
core   +5 more sources

Rethinking phosphatidylinositol 3-monophosphate

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second
Falasca M, Maffucci T
openaire   +4 more sources

Purification et caractérisation de la D-bêta-hydroxybutyrate déshydrogenase de mitochondries de foie de chamelon [PDF]

, 2000
La D-bêta-hydroxybutyrate déshydrogénase (BDH) est une protéine membranaire mitochondriale. Elle est située sur la face interne de la membrane interne, fortement liée à la membrane. C'est une oxydoréductase à NAD+ (H). Elle intervient dans le métabolisme
Cottin, P., El Kebbaj, M.S., Nasser, B., Poussard, S.   +3 more
core   +2 more sources

Relative quantification of deuterated omega-3 and -6 fatty acids and their lipid turnover in PC12 cell membranes using TOF-SIMS

Journal of Lipid Research, 2018
Understanding FA metabolism and lipid synthesis requires a lot of information about which FAs and lipids are formed within the cells. We focused on the use of deuterated substrates of 100 μM α-linolenic acid and linoleic acid to determine the relative ...
Mai H. Philipsen, Sanna Sämfors, Per Malmberg, Andrew G. Ewing   +3 more
doaj   +1 more source

A141

EJC Supplements, 2015
The aim of this study was to investigate the quantitative changes in the phospholipid (PL) content of peripheral blood mononuclear cells (MNC), plasma membrane (PM), fraction in breast (BC) and cervical cancers (CC) compared to normal levels.
H. Davtyan, G. Hakobyan, K. Alexsanyan, Y. Tadevosyan   +3 more
doaj   +1 more source

Late Effects of Disturbed IGF Signaling in Congenital Diseases. [PDF]

, 2007
The biologic effects of insulin-like growth factor-1 (IGF-1) are mediated by specific cell surface receptors. IGF-1 binding to the extracellular -subunits activates the tyrosine kinase intrinsic to the cytoplasmic portion of the IGF-1 receptor ...
Cianfarani S, Geremia C, Germani D, Maiorana A, Puglianiello A   +4 more
core   +1 more source