Results 81 to 90 of about 79,046 (379)

Characterization of the Regulation and Function of Phosphatidylinositol 3,5-Bisphosphate [PDF]

, 2021
Shannon Cheuk Ying Ho
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Mass spectrometry–based lipidomics of oral squamous cell carcinoma tissue reveals aberrant cholesterol and glycerophospholipid metabolism — A Pilot study

Translational Oncology, 2020
Lipid metabolic reprogramming is one hallmark of cancer. Lipid metabolism is regulated by numerous enzymes, many of which are targeted by several drugs on the market.
Amy Dickinson, Mayank Saraswat, Sakari Joenväärä, Rahul Agarwal, Daniel Jyllikoski, Tommy Wilkman, Antti Mäkitie, Suvi Silén   +7 more
doaj   +1 more source

Glycosyl-phosphatidylinositols of Trypanosoma congolense: two common precursors but a new protein-anchor.

Journal of Molecular Biology, 1996
The parasitic protozoan Trypanosoma congolense exhibits a dense surface coat which is pivotal for immunoevasion of the parasite. This dense surface coat is made of a single protein species, the variant surface glycoprotein, which is present in a high ...
P. Gerold, B. Striepen, B. Reitter, H. Geyer, R. Geyer, E. Reinwald, H. Risse, R. Schwarz   +7 more
semanticscholar   +1 more source

Short-term exposure to antimony induces hepatotoxicity and metabolic remodeling in rats

Ecotoxicology and Environmental Safety, 2023
Antimony (Sb) poses a significant threat to human health due to sharp increases in its exploitation and application globally, but few studies have explored the pathophysiological mechanisms of acute hepatotoxicity induced by Sb exposure.
Wen Gu, Ruifang Pang, Yuanyuan Chen, Fuchang Deng, Miao Zhang, Zijin Shao, Shuyi Zhang, Huawei Duan, Song Tang   +8 more
doaj   +1 more source

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Phagocytes are key to innate immunity, as they ingest, kill, and degrade foreign particles, such as microbes. Particle uptake results in the formation of phagosomes that eventually fuse with lysosomes, the main degradative compartments in cells.
Jeschke, Andreas, Zehethofer, Nicole, Lindner, Buko, Krupp, Jessica, Schwudke, Dominik, Haneburger, Ina, Jovic, Marko, Backer, Jonathan M, Balla, Tamas, Hilbi, Hubert, Haas, Albert   +10 more
openaire   +3 more sources

Reactivity of MEST-1 (antigalactofuranose) with Trypanosoma cruzi, glycosylinositol phosphorylceramides (GIPCs): Immunolocalization of GIPCs in acidic vesicles of epimastigotes [PDF]

, 2001
Using confocal microscopy, MEST-1-positive immunofluorescence was observed within various Trypanosoma cruzi forms, except in cell-derived trypomastigotes. Glycosylinositol phosphorylceramides were identified by thin-layer chromatography immunostaining as
Mortara, Renato A., Straus, Anita H., Suzuki, Erika, Takahashi, Helio K.   +3 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation[S]

Journal of Lipid Research, 2009
Molecular events involved in successful embryo implantation are not well understood. In this study, we used MALDI imaging mass spectrometry (IMS) technologies to characterize the spatial and temporal distribution of phospholipid species associated with ...
Kristin E. Burnum, Dale S. Cornett, Satu M. Puolitaival, Stephen B. Milne, David S. Myers, Susanne Tranguch, H. Alex Brown, Sudhansu K. Dey, Richard M. Caprioli   +8 more
doaj   +1 more source

Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice

Lipids in Health and Disease, 2022
Background Recent findings show that extracellular vesicle constituents can exert short- and long-range biological effects on neighboring cells in the brain, opening an exciting avenue for investigation in the field of neurodegenerative diseases ...
Melissa R. Pergande, Christina Kang, Diann George, Pearl A. Sutter, Stephen J. Crocker, Stephanie M. Cologna, Maria I. Givogri   +6 more
doaj   +1 more source