Results 141 to 150 of about 78,278 (294)
Small, EarlyView.The study introduces a 3D sensing‐integrated platform enabling real‐time, non‐invasive monitoring of pH dynamics in patient‐derived PDAC tumorspheres. It revealed distinct extracellular acidification patterns under FOLFIRINOX, gemcitabine, and paclitaxel, correlating with therapeutic efficacy.
Stefania Forciniti +10 more
wiley +1 more source
Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating
Small, EarlyView.Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim +4 more
wiley +1 more source
Proximity Proteomics Maps Candidate Cellular Uptake Pathways for Cell‐Derived Nanovesicles
Small Methods, EarlyView.TurboID‐based dual‐sided proteomics compares mechanically generated cell‐derived nanovesicles with naturally secreted small extracellular vesicles. Vesicle proteomes define candidate interaction signatures, while recipient‐cell proximity labelling identifies exposure‐associated proteins.
Eisuke Kanao +8 more
wiley +1 more source
Small Methods, EarlyView.Graphical Abstract. High‐speed atomic force microscopy enables real‐time, label‐free visualization of antibody interactions with individual extracellular vesicles. By quantifying binding frequency and dwell time, this approach reveals functional PD‐L1 accessibility that cannot be inferred from protein abundance alone, uncovering nanoscale heterogeneity
Reon Imakawa +10 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley +1 more source
Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity
VIEW, EarlyView.Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin +3 more
wiley +1 more source
Transport of phosphatidylserine from microsmes to the inner mitochondrial membrane in brain tissue
, 1993 Phosphatidylserine was labeled by incubating rat brain homogenates with [3-I4C]serine in the presence of Ca2+ (base-exchange conditions). Some labeled phosphatidylethanolamine also forms, in spite of the inhibition of Ca" on phosphatidylserine ...
ARIENTI G. +3 more
core
Improving ARTs: Microfluidics as a Tool for Sperm Selection
Andrology, EarlyView.ABSTRACT Sperm selection is a critical step in assisted reproductive technology (ART), as sperm quality directly influences embryo quality. In vivo, the female reproductive tract imposes several physical and physiological barriers that favors only the most optimal spermatozoa reaching the fertilization site.
A. Pérez‐Gómez +7 more
wiley +1 more source
Nine-Week Co-Supplementation with Sugarcane Wax Alcohol (Policosanol), Phosphatidylserine, and <i>Ginkgo biloba</i> Leaf Extract Attenuates the Metabolic Dysfunction and Oxidative Stress in Blood and Vital Organs of Hyperlipidemic/Hyperglycemic Zebrafish. [PDF]
Int J Mol SciCho KH +6 more
europepmc +1 more source
Cancer Science, EarlyView.Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal +16 more
wiley +1 more source