Results 151 to 160 of about 41,016 (180)
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Cell Biology, Physiology and Enzymology of Phosphatidylserine Decarboxylase
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2017Phosphatidylethanolamine is one of the most abundant phospholipids whose major amounts are formed by phosphatidylserine decarboxylases (PSD). Here we provide a comprehensive description of different types of PSDs in the different kingdoms of life. In eukaryotes, type I PSDs are mitochondrial enzymes, whereas other PSDs are localized to other cellular ...
Francesca Di Bartolomeo, Günther Daum
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Developmental Pattern for Phosphatidylserine Decarboxylase in Rat Brain
Journal of Neurochemistry, 1986Abstract: In adult rats, a significant portion of brain ethanolamine glycerophospholipids are synthesized by a pathway involving phosphatidylserine decarboxylase, a mitochondrial enzyme. We have now examined whether this enzyme plays a particularly prominent role during development.
Pierre Morell, Arrel D Toews, A D Toews
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The Role of Phosphatidylserine Decarboxylase in Brain Phospholipid Metabolism
Journal of Neurochemistry, 1983Abstract: In brain, phosphatidylethanolamine can be synthesized from free ethanolamine either by a pathway involving the formation of CDP‐ethanolamine and its transfer to diglyceride, or by base‐exchange of ethanolamine with existing phospholipids. Although de novo synthesis from serine has also been demonstrated, the metabolic pathway involved is not
Pierre Morell
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Conditional lethal phosphatidylserine decarboxylase mutants of Escherichia coli
Molecular and General Genetics MGG, 1976The final step in the biosynthesis of phosphatidylethanolamine, the major membrane lipid of Escherichia coli, is catalyzed by the membrane-bound enzyme, phosphatidylserine decarboxylase. A variation of a procedure for localized mutagenesis (Hong and Ames, 1971) was employed to generate conditional lethal mutants in phosphatidylserine decarboxylase.
E, Hawrot, E P, Kennedy
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Phosphatidylserine decarboxylase
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1997Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes. The cloned bacterial gene encodes an integral membrane protein that is first made as a proenzyme, and subsequently proteolyzed to an alpha subunit, containing a pyruvoyl prosthetic group, and a beta subunit. Two
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Fungal Genetics and Biology, 2021
Phosphatidylserine decarboxylases (Psds) are enzymes regulating phosphatidylethanolamine biosynthesis in prokaryotes and eukaryotes, and have the central role in lipid metabolism. To date, the functions of Psds in plant pathogenic fungi are not fully understood.
Lin Tang +10 more
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Phosphatidylserine decarboxylases (Psds) are enzymes regulating phosphatidylethanolamine biosynthesis in prokaryotes and eukaryotes, and have the central role in lipid metabolism. To date, the functions of Psds in plant pathogenic fungi are not fully understood.
Lin Tang +10 more
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High-Throughput Mass Spectrometry Screening for Inhibitors of Phosphatidylserine Decarboxylase. [PDF]
Journal of Biomolecular Screening, 2007 A high-throughput mass spectrometry assay to measure the catalytic activity of phosphatidylserine decarboxylase (PISD) is described. PISD converts phosphatidylserine to phosphatidylethanolamine during lipid synthesis. Traditional methods of measuring PISD activity are low throughput and unsuitable for the high-throughput screening of large compound ...
Chris D, Forbes +9 more
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Doxorubicin inhibits phosphatidylserine decarboxylase and confers broad-spectrum antifungal activity
New Phytologist, 2023Summary As phospholipids of cell membranes, phosphatidylethanolamine (PE) and phosphatidylserine (PS) play crucial roles in glycerophospholipid metabolism. Broadly, some phospholipid biosynthesis enzymes serve as potential fungicide targets.
Yaru Zhou +15 more
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Biochimica Et Biophysica Acta - Biomembranes, 1986
Large unilamellar vesicles (LUV) that contained a fluorescent analog of phosphatidylserine (NBD-PS) were used in model systems to determine the feasibility of employing phosphatidylserine decarboxylase (PS-decarboxylase) to generate asymmetric vesicles and to determine the transbilayer distribution of PS.
Alan J Schroit, A J Schroit
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Large unilamellar vesicles (LUV) that contained a fluorescent analog of phosphatidylserine (NBD-PS) were used in model systems to determine the feasibility of employing phosphatidylserine decarboxylase (PS-decarboxylase) to generate asymmetric vesicles and to determine the transbilayer distribution of PS.
Alan J Schroit, A J Schroit
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Assay for phosphatidylserine decarboxylase utilizing DEAE-cellulose column chromatography
Analytical Biochemistry, 1989A simple assay for phosphatidylserine decarboxylase is described. Following incubation of a mitochondrial fraction from Saccharomyces cerevisiae with purified, exogenous phosphatidyl[3H]serine, the lipid extract is applied to a small DEAE-cellulose column equilibrated in CHCI3-CH3OH (1:1).
J H, Overmeyer, C J, Waechter
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