Results 61 to 70 of about 9,580 (237)

Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol

Antioxidants, 2020
UV radiation is a well-established environmental risk factor known to cause oxidative stress and disrupt the metabolism of keratinocyte phospholipids. Cannabidiol (CBD) is a phytocannabinoid with anti-inflammatory and antioxidant effects.
Wojciech Łuczaj, Maria do Rosário Domingues, Pedro Domingues, Elżbieta Skrzydlewska   +3 more
doaj   +1 more source

Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics

Frontiers in Pharmacology, 2022
This study aimed to investigate the effects and underlying mechanisms of tormentic acid (TA) on carbon tetrachloride (CCl4)-induced liver fibrosis in rats.
Xing Lin, Yuanyuan Wei, Yan Li, Yuhua Xiong, Bin Fang, Cuiyu Li, Quanfang Huang, Renbin Huang, Jinbin Wei   +8 more
doaj   +1 more source

Anti-inflammatory and antithrombotic properties of polar lipid extracts, rich in unsaturated fatty acids, from the Irish marine cyanobacterium Spirulina subsalsa

Journal of Functional Foods, 2022
The characterization of cardio-protective lipid bioactives from cyanobacteria, such as Spirulina spp., has rarely been investigated. In this study, neutral lipids, glycolipids, and phospholipids of Irish marine cyanobacterium Spirulina subsalsa, were ...
Katie Shiels, Alexandros Tsoupras, Ronan Lordan, Ioannis Zabetakis, Patrick Murray, Sushanta Kumar Saha   +5 more
doaj  

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide [PDF]

, 2016
Introduction: Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs.
Avery, Vicky M., Baell, Jonathan B., Creek, Darren J., Ellis, Katherine M., Ferrins, Lori, Jones, Amy J., McConville, Malcolm J., Nowell, Cameron J., Rahmani, Raphael, Read, Kevin D., Riley, Jennifer, Stoessel, Daniel   +11 more
core   +2 more sources

Phosphatidylserine dynamics in cellular membranes [PDF]

Molecular Biology of the Cell, 2012
Much has been learned about the role of exofacial phosphatidylserine (PS) in apoptosis and blood clotting using annexin V. However, because annexins are impermeant and unable to bind PS at low calcium concentration, they are unsuitable for intracellular use. Thus little is known about the topology and dynamics of PS in the endomembranes of normal cells.
Kay, J.G., Koivusalo, M., Ma, X., Wohland, T., Grinstein, S.   +4 more
openaire   +2 more sources

Prospects of apoptotic cell-based therapies for transplantation and inflammatory diseases.

, 2013
International audienceApoptotic cell removal or interactions of early-stage apoptotic cells with immune cells are associated with an immunomodulatory microenvironment that can be harnessed to exert therapeutic effects.
Ariel, Bellingan, Bournazou, Caruso, Chang, Coles, Dini, Golpon, Griffith, Hall, Huynh, Idoyaga, Ip, Kirsch, Kurosaka, Liu, Maeda, Mevorach, Paidassi, Philippe Saas, Ravishankar, Ren, Sandra Kaminski, Seitz, Shibata, Stuart, Sylvain Perruche, Tso, Wood   +28 more
core   +3 more sources

Electrochemical regulation of budding yeast polarity.

PLoS Biology, 2014
Cells are naturally surrounded by organized electrical signals in the form of local ion fluxes, membrane potential, and electric fields (EFs) at their surface.
Armin Haupt, Alexis Campetelli, Daria Bonazzi, Matthieu Piel, Fred Chang, Nicolas Minc   +5 more
doaj   +1 more source

Platelet senescence and phosphatidylserine exposure [PDF]

Transfusion, 2010
BACKGROUND: The exposure of phosphatidylserine occurs during platelet (PLT) activation and during in vitro storage. Phosphatidylserine exposure also occurs during apoptosis after the release of mitochondrial cytochrome c. We have examined the role of cytochrome c release, mitochondrial membrane potential (ΔΨm), and cyclophilin D (CypD) in ...
Jorge Garza, Jorge Garza, Eduardo Rios Argaiz, Eduardo Rios Argaiz, Jose Emmanel Chedid Mercado, Jose Emmanel Chedid Mercado, Ana Bety Enriquez, Ana Bety Enriquez, Hector Omar Elizondo Maul, Hector Omar Elizondo Maul, Hanan Abdel-Monem, Hanan Abdel-Monem, Michael Andreeff, Anthony Prakasam, Anthony Prakasam, Perumal Thiagarajan, Perumal Thiagarajan, Perumal Thiagarajan, Swapan K. Dasgupta   +18 more
openaire   +2 more sources

Antiphosphatidylserine antibody as a cause of multiple dural venous sinus thromboses and ST-elevation myocardial infarction [PDF]

, 2018
Objective: Rare disease Background: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antibodies directed against phos-pholipids on plasma membranes. Through unclear mechanisms, APS confers hypercoagulability.
Marquardt, Caillin W., Pickens, Peter V., Varner, Chelsea K.   +2 more
core   +1 more source

Metabolomics and biochemical alterations caused by pleiotrophin in the 6‑hydroxydopamine mouse model of Parkinson’s disease. [PDF]

, 2022
Pleiotrophin (PTN) is a cytokine involved in nerve tissue repair processes, neuroinflammation and neuronal survival. PTN expression levels are upregulated in the nigrostriatal pathway of Parkinson’s Disease (PD) patients.
Barbas, Coral, Fernández‑Calle, Rosalía, Ferrer‑Alcón, Marcel, Gramage, Esther, Herradón, Gonzalo, Martín Martínez, Yasmina, Sáiz, Jorge, Uribarri, María   +7 more
core   +1 more source