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Intermolecular Enantioselective Nickel‐Catalyzed Arylation of Un‐Activated C(sp3)─H Bond

open access: yesAngewandte Chemie International Edition, EarlyView.
Ni: a new solution for asymmetric C(sp3)─H activation. The stereoselective synthesis of all‐carbon quaternary stereogenic centres is achieved via enantioselective C(sp3)─H arylation using a Ni‐BINOL‐derived catalyst. Rational catalytic cycle design uncovers a new reaction pathway that can efficiently induce chiral information during the stereoselective
Erwan Brunard   +4 more
wiley   +1 more source

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