Results 131 to 140 of about 19,150 (267)

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

open access: yesBMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu   +12 more
wiley   +1 more source

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

open access: yesBiotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya   +7 more
wiley   +1 more source

Formation of a 14‐Electron Intermediate in Iridium Catalysis through Reductive Elimination: Dissociation Is Rate Determining

open access: yesChemistryEurope, EarlyView.
Dynamic NMR and trapping studies reveal that POCOP–Ir phenyl hydride complexes perform reductive coupling rapidly but dissociate benzene slowly. PCP–Ir analogs show comparatively slow reductive coupling and faster dissociation. This work experimentally clarifies aspects of C–H reductive elimination in iridium pincer complexes.(POCOP = bisphosphinite ...
Alice Spangenberg, Ola F. Wendt
wiley   +1 more source

Exploring Indium Teflates: From Neutral In(OTeF5)3(THF)3 to Anionic Complexes [In(OTeF5)4(THF)2]– and [In(OTeF5)6]3–

open access: yesChemistryEurope, EarlyView.
The study examines the coordination chemistry of indium teflate complexes, showing the progression from [In(OTeF5)3(THF)3] to the anionic species [In(OTeF5)4(THF)2]– and [In(OTeF5)6]3–. Systematic ligand substitution and anion formation reveal increasing teflate coordination, highlighting structural evolution, Lewis acidity modulation, and ...
Djamila Azrou   +7 more
wiley   +1 more source

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