Results 141 to 150 of about 48,855 (331)

Role of epicardial adipose tissue in heart failure with preserved ejection fraction: An emerging molecular mechanism and therapeutic potential

Obesity Reviews, EarlyView.
Summary With the evolving landscape of diseases, heart failure with preserved ejection fraction (HFpEF) now encompasses more than half of all heart failure patients. This condition is clinically diverse, involving multiple organ systems and often occurring alongside the aging process.
Zhongwen Qi, Dan Wu, Zhipeng Yan, Qing Wang, Yiming Li, Junnan Zhao, Fengqin Xu   +6 more
wiley   +1 more source

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm [PDF]

, 2016
Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of ...
Abozguia, AIRE Study Group, Alexander, Alexander, Alexander, Alexander, Ashrafian, Bailey, Bailey, Basu, Beadle, Braunwald, Brown, Burgoyne, Chaitman, Chatterjee, Chung, CIBIS-II Study Group, Cleland, Clerc, Cohn, Cohn, Cohn, CONSENSUS Trial Study Group, Conway, Cook, Dai, Digitalis Investigation Group, Doenst, Dzau, Dzau, Faris, Flather, Follath, Foster, Fox, Fox, Fragasso, Furberg, Gheorghiade, Gladwin, Goffart, Granger, Greenberg, Guazzi, Guazzi, Heymans, Hobbs, Holubarsch, Horowitz, Horowitz, Kantor, Kapil, Kato, Kennedy, Kennedy, Kostis, Larsen, Lee, Lopaschuk, Luiken, Lundberg, Maher, Maier, Mancini, Mann, Mann, Massie, Mccormack, Mcdowell, Mcmurray, Mcmurray, Merit-Hf Study Group, Munzel, Munzel, Neglia, Neubauer, Ormerod, Packer, Packer, Paul, Pawson, Pfeffer, Pfeffer, Pitt, Pitt, Rathore, Rauchhaus, Redfield, Rona, Sack, Sarraf, Schmidt-Schweda, Schrauwen, Schwarz, Shah, Shah, Siddiqi, Singh, SOLVD Investigators, Stanley, Swedberg, Szwed, Taylor, Teerlink, Tilemann, Torre-Amione, Totzeck, Turcani, Unger, Van Der Vusse, Van Faassen, Vardeny, Webb, Yin, Yusuf, Zamani, Zannad, Zannad, Zhang   +119 more
core   +1 more source

Skeletal muscle mitochondrial correlates of critical power and W' in healthy active individuals

Experimental Physiology, EarlyView.
Abstract The asymptote (critical power; CP) and curvature constant (W') of the hyperbolic power–duration relationship can predict performance within the severe‐intensity exercise domain. However, the extent to which these parameters relate to skeletal muscle mitochondrial content and respiratory function is not known.
Donald L. Peden, Robert Rogers, Emma A. Mitchell, Suzanne M. Taylor, Stephen J. Bailey, Richard A. Ferguson   +5 more
wiley   +1 more source

Improved Exercise Tolerance with Caffeine Is Associated with Modulation of both Peripheral and Central Neural Processes in Human Participants

Frontiers in Nutrition, 2018
BackgroundCaffeine has been shown to enhance exercise performance and capacity. The mechanisms remain unclear but are suggested to relate to adenosine receptor antagonism, resulting in increased central motor drive, reduced perception of effort, and ...
Joanna L. Bowtell, Magni Mohr, Magni Mohr, Magni Mohr, Jonathan Fulford, Sarah R. Jackman, Georgios Ermidis, Georgios Ermidis, Georgios Ermidis, Peter Krustrup, Peter Krustrup, Katya N. Mileva   +11 more
doaj   +1 more source

Durability as an index of endurance exercise performance: Methodological considerations

Experimental Physiology, EarlyView.
Abstract Endurance athletes routinely complete physiological assessments to predict performance, inform training programmes and monitor subsequent training adaptations. This profiling is typically performed with the athlete in a ‘fresh’ (i.e., rested) condition, but physiological profiling variables deteriorate during prolonged exercise. Durability has
Ben Hunter, Ed Maunder, Andrew M. Jones, Gabriele Gallo, Daniel Muniz‐Pumares   +4 more
wiley   +1 more source

Fast 3D 31P B1+ mapping with a weighted stack of spiral trajectory at 7 Tesla [PDF]

arXiv
Purpose: Phosphorus Magnetic Resonance Spectroscopy (31P MRS) enables non-invasive assessment of energy metabolism, yet its application is hindered by sensitivity limitations. To overcome this, often high magnetic fields are used, leading to challenges such as spatial B_1^+ inhomogeneity and therefore the need for accurate flip angle determination in ...
arxiv  

Oxidative and O2 diffusive function in triceps brachii of recreational to world class swimmers

Experimental Physiology, EarlyView.
Abstract This study aimed to evaluate in vivo oxidative capacity and relative resistance to O2 diffusion using near‐infrared spectroscopy (NIRS) in the m. triceps brachii of recreational to world class swimmers and evaluate their relationships with swimming performance.
Simone Villanova, Elisa Pastorio, Andrea M. Pilotto, Alessio Marciano, Valentina Quaresima, Alessandra Adami, Harry B. Rossiter, Daniele A. Cardinale, Simone Porcelli   +8 more
wiley   +1 more source

The three-dimensional impulse-response model: Modeling the training process in accordance with energy system-specific adaptation [PDF]

arXiv
Athletic training is characterized by physiological systems responding to repeated exercise-induced stress, resulting in gradual alterations in the functional properties of these systems. The adaptive response leading to improved performance follows a remarkably predictable pattern that may be described by a systems model provided that training load ...
arxiv  

THE EFFECT OF ANTIDEPRESSIVE DRUGS AND SOME RELATED COMPOUNDS ON THE LEVELS OF ADENINE NUCLEOTIDES, INORGANIC PHOSPHATE AND PHOSPHOCREATINE IN THE RAT BRAIN [PDF]

, 1963
J J Lewis, G. R. Van Petten
openalex   +1 more source

Acute alterations in blood lactate in the setting of transient stress induced myocardial ischaemia

Experimental Physiology, EarlyView.
Abstract An elevation in resting venous blood lactate ([La−]b) levels in conditions of myocardial hypoperfusion is associated with adverse prognosis and survival. This investigation aimed to assess changes in venous [La−]b levels induced by dobutamine stress in the presence and absence of myocardial ischaemia and adverse outcomes at 1 year.
Jamie M. O'Driscoll, Elliot Smith, Matchel Bibat, Jamie J. Edwards, Claire Compton, Konstantina Kipourou, Damian Coleman, Jonathan Wiles, Eliane Cunliffe, Anna Marciniak, Rajan Sharma   +10 more
wiley   +1 more source