Results 171 to 180 of about 52,049 (355)

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early‐onset sleep disruption in AD‐like amyloidogenic mice

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep–wake disturbances frequently occur at early stages of Alzheimer's disease (AD) and accelerate disease progression, but the underlying neural mechanisms are not fully understood. METHODS We examined sleep–wake behavior and locus coeruleus (LC) activity in young 5xFAD mice using electrophysiology and pharmacological approaches
Yi‐Ci Zhang, Xue‐Ting Zhang, Peng‐Yue Chen, Zi‐Yue Zhou, Mao‐Qing Huang, Kai‐Wen He   +5 more
wiley   +1 more source

(Phospho)creatine: the reserve and merry-go-round of brain energetics

Neural Regeneration Research, 2023
Hong-Ru Chen, Ton DeGrauw, Chia-Yi Kuan
doaj   +1 more source

Adenosine triphosphate and phosphocreatine levels in cochlear structures. Use rate and effect of salicylates. [PDF]

, 1975
J J Krzanowski, F M Matschinsky
openalex   +1 more source

Acute Hypoxia Decreases Maximum Fat Oxidation Rate During Step Incremental Exercise Normalized to Respiratory Compensation Point

European Journal of Sport Science, Volume 26, Issue 2, February 2026.
ABSTRACT Whether fat oxidation (FATox) is altered during exercise in hypoxia remains equivocal due to differences in experimental protocols. Furthermore, to date no investigation has reported the effect of hypoxia on maximal fat oxidation rate (MFO).
Youmna Elsayed Hassanein, Dania Ibrahim, Juan M. Murias, Nathan Townsend   +3 more
wiley   +1 more source

Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Excess adiposity is a major risk factor for insulin resistance, prediabetes, and Type 2 diabetes and increases the risk for sarcopenia and osteosarcopenia later in life. It has been proposed that altered metabolic function and musculoskeletal status in people with obesity are directly linked, presumably because they share common ...
Alan Fappi, Clifton J. Holmes, Chao Cao, Vasavi Shabrish, Aman P. Aher, Karen Shen, Paul K. Commean, Dwight A. Towler, Dominic N. Reeds, Gretchen A. Meyer, Bettina Mittendorfer   +10 more
wiley   +1 more source

Metabolic Inertia in Contracting Skeletal Muscle: The Expanding Role of the Carnitine Pool [PDF]

, 2018
Summary.: The ability of the muscular carnitine pool to accept and temporally donate acetyl groups (from and towards the coenzyme A pool) is an important functional role of carnitine within biological systems that is often overlooked within the ...
Roberts, Paul A.
core  

Simultaneous in vivo detection of spectrally resolved glutamate, glutamine, and glutathione at 3 T with NAA‐aspartyl editing and echo‐time optimization

Magnetic Resonance in Medicine, Volume 95, Issue 2, Page 668-679, February 2026.
Abstract Purpose To achieve spectrally resolved in vivo detection of glutamate, glutamine, and glutathione at 3 T. Methods Difference editing of N‐acetylaspartate CH2 protons (NAA‐CH2) combined with a new echo‐time (TE) optimization approach is introduced.
Li An, Sungtak Hong, Tara Turon, Adriana J. Pavletic, Christopher S. Johnson, Jun Shen   +5 more
wiley   +1 more source

Supplementary Table S6 from Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2

Lishu Chen, Qinghui Qi, Xiaoqing Jiang, Jin Wu, Yuanyuan Li, Zhaodan Liu, Yan Cai, Haowen Ran, Songyang Zhang, Cheng Zhang, Huiran Wu, Shuailiang Cao, Lanjuan Mi, Dake Xiao, Haohao Huang, Shuai Jiang, Jiaqi Wu, Bohan Li, Jiong Xie, Ji Qi, Fangye Li, Panpan Liang, Qiuying Han, Min Wu, Wenchao Zhou, Chenhui Wang, Weina Zhang, Xin Jiang, Kun Zhang, Huiyan Li, Xuemin Zhang, Ailing Li, Tao Zhou, Jianghong Man   +33 more
openalex   +2 more sources

Inverting CEST or R1ρ$$ {R}_{1\uprho} $$ data to generate solute spectra without a priori assumptions

Magnetic Resonance in Medicine, Volume 95, Issue 2, Page 1239-1254, February 2026.
Abstract Purpose The goal of CEST imaging is to reveal the underlying tissue composition and exchange. However, quantitative CEST analyses typically require strong assumptions about this same composition and exchange. The goal of this paper is to introduce a new CEST analysis (also applicable to rotating frame relaxation rate R1ρ$$ {R}_{1\uprho ...
Daniel F. Gochberg
wiley   +1 more source

Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK‐ULK1‐Mediated Mitochondrial Quality Control

Aging Cell, Volume 25, Issue 2, February 2026.
Dietary protein restriction protects the aging heart in the context of obesity by limiting mitochondrial DNA leakage and suppressing cGAS–STING‐driven inflammation. Through AMPK–ULK1‐dependent mitophagy, protein restriction restores mitochondrial quality control, reduces cardiac remodeling, and preserves metabolic homeostasis during obesity‐associated ...
Wagner S. Dantas, Elizabeth R. M. Zunica, Elizabeth C. Heintz, Charles L. Hoppel, Cristal M. Hill, Christopher D. Morrison, Christopher L. Axelrod, Gangarao Davuluri, John P. Kirwan   +8 more
wiley   +1 more source