Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine [PDF]
Nature, 2021 Adaptive thermogenesis has attracted much attention because of its ability to increase systemic energy expenditure and to counter obesity and diabetes1-3. Recent data have indicated that thermogenic fat cells use creatine to stimulate futile substrate cycling, dissipating chemical energy as heat4,5.
Yizhi Sun +16 more
semanticscholar +5 more sources
Nongenomic effects of aldosterone on phosphocreatine levels in human calf muscle during recovery from exercise. [PDF]
, 1996 Nongenomic in vitro effects of aldosterone on the sodium-proton antiport and intracellular second messengers have been described in human mononuclear leukocytes, vascular smooth muscle cells, and endothelial cells.
Gerzer, Rupert +4 more
core +3 more sources
Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line‐shape fitting CEST method [PDF]
Magnetic Resonance in Medicine, 2018 To obtain high‐resolution Cr and PCr maps of mouse skeletal muscle using a polynomial and Lorentzian line‐shape fitting (PLOF) CEST method.
Lin Chen +4 more
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Mitochondrial regulation of phosphocreatine/inorganic phosphate ratios in exercising human muscle: a gated 31P NMR study. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1981 31P NMR is used to determine the relationship between work output in the exercising human forearm and the steady-state capability of oxidative phosphorylation as measured by the phosphocreatine/inorganic phosphate ratio (PCr/Pi).
B Chance +4 more
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High-voltage-activated Ca2+ currents and the excitability of pyramidal neurons in the hippocampal CA3 subfield in rats depend on corticosterone and time of day [PDF]
PLoS ONE, 2001 This study tested the time-of-day dependence of the intrinsic postsynaptic properties of hippocampal CA3 pyramidal neurons. High-voltage-activated Ca2+ currents and the Ca2+- and voltage-dependent afterhyperpolarizations were examined in slices of rat ...
Avery +22 more
core +10 more sources
Cardiac protection with phosphocreatine: a meta-analysis
Interactive CardioVascular and Thoracic Surgery, 2016 Phosphocreatine (PCr) plays an important role in the energy metabolism of the heart and a decrease in its intracellular concentration results in alteration of myocardium energetics and work. We conducted a meta-analysis of all randomized and matched trials that compared PCr with placebo or standard treatment in patients with coronary artery disease or ...
LANDONI, GIOVANNI +6 more
openaire +5 more sources
Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure [PDF]
European Heart Journal, 2006 AIMS The addition of trimetazidine to standard treatment has been shown to improve left ventricular (LV) function in patients with heart failure. The aim of this study is to non-invasively assess, by means of in vivo 31P-magnetic resonance spectroscopy ...
Gabriele Fragasso +9 more
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Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles
Einstein (São Paulo), 2014 Adenosine triphosphate is the present energy currency in the body, and is used in various cellular and indispensable processes for the maintenance of cell homeostasis.
Lucas Guimarães-Ferreira
doaj +2 more sources
Comparison of in vivo postexercise phosphocreatine recovery and resting ATP synthesis flux for the assessment of skeletal muscle mitochondrial function [PDF]
American Journal of Physiology - Cell Physiology, 2010 (31)P magnetic resonance spectroscopy (MRS) has been used to assess skeletal muscle mitochondrial function in vivo by measuring 1) phosphocreatine (PCr) recovery after exercise or 2) resting ATP synthesis flux with saturation transfer (ST). In this study,
Nicole M. A. van den Broek +3 more
openalex +2 more sources
The determination and distribution of phosphocreatine in animal tissues [PDF]
Biochemical Journal, 1952 A. H. Ennor, H. Rosenberg
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