Results 1 to 10 of about 225,115 (385)

A PURIFICATION OF VENOM PHOSPHODIESTERASE

Journal of Biological Chemistry, 1952
For purposes of analysis of polynucleotides, it is desirable to have a phosphodiesterase, substantially free of 5-nucleotidase or other phosphatase activity. The presence of a phosphodiesterase in a wide variety of snake venoms was demonstrated by Gullan and Jackson (1). These venoms were found also to contain a potent 5-nucleotidase, but were free of
Robert L. Sinsheimer, James F. Koerner
openalex   +5 more sources

Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension: Focus on Phosphodiesterase Inhibitors

Pharmaceuticals, 2022
Pulmonary hypertension (PH) is common in patients with heart failure with preserved ejection fraction (HFpEF). A chronic increase in mean left atrial pressure leads to passive remodeling in pulmonary veins and capillaries and modest PH (isolated ...
Artem Ovchinnikov, Alexandra Potekhina, Evgeny Belyavskiy, Fail Ageev   +3 more
doaj   +1 more source

C-di-AMP Is a Second Messenger in Corynebacterium glutamicum That Regulates Expression of a Cell Wall-Related Peptidase via a Riboswitch

Microorganisms, 2023
Cyclic di-adenosine monophosphate (c-di-AMP) is a bacterial second messenger discovered in Bacillus subtilis and involved in potassium homeostasis, cell wall maintenance and/or DNA stress response.
Sebastian J. Reich, Oliver Goldbeck, Tsenguunmaa Lkhaasuren, Dominik Weixler, Tamara Weiß, Bernhard J. Eikmanns   +5 more
doaj   +1 more source

YciR, a Specific 3′-Phosphodiesterase, Plays a Role in the Pathogenesis of Uropathogenic Escherichia coli CFT073

Frontiers in Microbiology, 2022
Urinary tract infections (UTIs), with the characteristics of recurrence and resistance to antibiotics due to misuse, remain a common health and economic issue for patients.
Si Zhang, Si Zhang, Jingting Wang, Yu Fan, Wang Meng, Chengqian Qian, Peng Liu, Yi Wei, Chao Yuan, Yuhui Du, Zhiqiu Yin   +10 more
doaj   +1 more source

Discovery of Dipyridamole Analogues with Enhanced Metabolic Stability for the Treatment of Idiopathic Pulmonary Fibrosis

Molecules, 2022
Dipyridamole, apart from its well-known antiplatelet and phosphodiesterase inhibitory activities, is a promising old drug for the treatment of pulmonary fibrosis.
Meng-Xing Huang, Yan-Quan Chen, Run-Duo Liu, Yue Huang, Chen Zhang   +4 more
doaj   +1 more source

The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the Grewia tenax Fruit Extract: In Vivo and Ex Vivo Approach

Molecules, 2022
The study was performed to assess and rationalize the traditional utilization of the fruit part of Grewia tenax (G. tenax). The phytoconstituents present in the methanolic extract were analyzed using Gas-Chromatography-Mass Spectroscopy (GC-MS), while ...
Najeeb Ur Rehman, Mohd Nazam Ansari, Wasim Ahmad, Mohd Amir   +3 more
doaj   +1 more source

Phosphodiesterase inhibitors [PDF]

British Journal of Pharmacology, 2006
Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and thus play a key role in regulating intracellular levels of the second messengers cAMP and cGMP, and hence cell function. Theophylline and papaverine have historically been used therapeutically and are known to be weak inhibitors of PDE, but to what extent this ...
Boswell-Smith, V, Spina, D, Page, C P
openaire   +4 more sources

Activation and Antagonism of the OAS–RNase L Pathway

Proceedings, 2020
The oligoadenylate synthetase–ribonuclease L (OAS–RNase L) system is a potent antiviral pathway that severely limits the pathogenesis of many viruses. Upon sensing dsRNA, OASs produce 2′,5′-oligoadenylates (2-5A) that activate RNase L to cleave both host
Susan R. Weiss
doaj   +1 more source

Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes

Open Biology, 2022
Cyclic guanosine monophosphate (cGMP) signalling plays a fundamental role in many cell types, including platelets. cGMP has been implicated in platelet formation, but mechanistic detail about its spatio-temporal regulation in megakaryocytes (MKs) is ...
Yujing Zhang, Pascal Benz, Daniel Stehle, Shang Yang, Hendrikje Kurz, Susanne Feil, Georg Nagel, Robert Feil, Shiqiang Gao, Markus Bender   +9 more
doaj   +1 more source

The evolution and structure of snake venom phosphodiesterase (svPDE) highlight its importance in venom actions

eLife, 2023
For decades, studies of snake venoms focused on the venom-ome-specific toxins (VSTs). VSTs are dominant soluble proteins believed to contribute to the main venomous effects and emerged into gene clusters for fast adaptation and diversification of snake ...
Cheng-Tsung Pan, Chien-Chu Lin, I-Jin Lin, Kun-Yi Chien, Yeong-Shin Lin, Hsiao-Han Chang, Wen-Guey Wu   +6 more
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