Results 1 to 10 of about 229,623 (284)

Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension: Focus on Phosphodiesterase Inhibitors

Pharmaceuticals, 2022
Pulmonary hypertension (PH) is common in patients with heart failure with preserved ejection fraction (HFpEF). A chronic increase in mean left atrial pressure leads to passive remodeling in pulmonary veins and capillaries and modest PH (isolated ...
Artem Ovchinnikov, Alexandra Potekhina, Evgeny Belyavskiy, Fail Ageev   +3 more
doaj   +1 more source

Clinical Implication of Phosphodiesterase-4-Inhibition

International Journal of Molecular Sciences, 2022
The pleiotropic function of 3′,5′-cyclic adenosine monophosphate (cAMP)-dependent pathways in health and disease led to the development of pharmacological phosphodiesterase inhibitors (PDE-I) to attenuate cAMP degradation.
M. Schick, N. Schlegel
semanticscholar   +1 more source

C-di-AMP Is a Second Messenger in Corynebacterium glutamicum That Regulates Expression of a Cell Wall-Related Peptidase via a Riboswitch

Microorganisms, 2023
Cyclic di-adenosine monophosphate (c-di-AMP) is a bacterial second messenger discovered in Bacillus subtilis and involved in potassium homeostasis, cell wall maintenance and/or DNA stress response.
Sebastian J. Reich, Oliver Goldbeck, Tsenguunmaa Lkhaasuren, Dominik Weixler, Tamara Weiß, Bernhard J. Eikmanns   +5 more
doaj   +1 more source

The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors

Andrology, 2022
Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first‐line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data suggest that diabetic men may be ...
A. Cayetano-Alcaraz, T. Tharakan, Runzhi Chen, N. Sofikitis, S. Minhas   +4 more
semanticscholar   +1 more source

Difamilast, a selective phosphodiesterase 4 inhibitor, ointment in paediatric patients with atopic dermatitis: a phase III randomized double‐blind, vehicle‐controlled trial

British Journal of Dermatology, 2021
In atopic dermatitis (AD), phosphodiesterase 4 (PDE4) inhibition reduces proinflammatory mediators and cytokines. Difamilast is a new selective PDE4 inhibitor.
H. Saeki, N. Baba, K. Ito, D. Yokota, H. Tsubouchi   +4 more
semanticscholar   +1 more source

Phosphodiesterase-4 Inhibition in Psoriasis

Psoriasis, 2021
Psoriasis is a chronic immune-mediated inflammatory disorder. Phosphodiesterase-4 (PDE-4) is an enzyme that mediates inflammatory responses and plays a role in psoriasis pathogenesis.
M. Milakovic, M. Gooderham
semanticscholar   +1 more source

YciR, a Specific 3′-Phosphodiesterase, Plays a Role in the Pathogenesis of Uropathogenic Escherichia coli CFT073

Frontiers in Microbiology, 2022
Urinary tract infections (UTIs), with the characteristics of recurrence and resistance to antibiotics due to misuse, remain a common health and economic issue for patients.
Si Zhang, Si Zhang, Jingting Wang, Yu Fan, Wang Meng, Chengqian Qian, Peng Liu, Yi Wei, Chao Yuan, Yuhui Du, Zhiqiu Yin   +10 more
doaj   +1 more source

Discovery of Dipyridamole Analogues with Enhanced Metabolic Stability for the Treatment of Idiopathic Pulmonary Fibrosis

Molecules, 2022
Dipyridamole, apart from its well-known antiplatelet and phosphodiesterase inhibitory activities, is a promising old drug for the treatment of pulmonary fibrosis.
Meng-Xing Huang, Yan-Quan Chen, Run-Duo Liu, Yue Huang, Chen Zhang   +4 more
doaj   +1 more source

The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the Grewia tenax Fruit Extract: In Vivo and Ex Vivo Approach

Molecules, 2022
The study was performed to assess and rationalize the traditional utilization of the fruit part of Grewia tenax (G. tenax). The phytoconstituents present in the methanolic extract were analyzed using Gas-Chromatography-Mass Spectroscopy (GC-MS), while ...
Najeeb Ur Rehman, Mohd Nazam Ansari, Wasim Ahmad, Mohd Amir   +3 more
doaj   +1 more source

Phosphodiesterase inhibitors [PDF]

British Journal of Pharmacology, 2006
Phosphodiesterases are a diverse family of enzymes that hydrolyse cyclic nucleotides and thus play a key role in regulating intracellular levels of the second messengers cAMP and cGMP, and hence cell function. Theophylline and papaverine have historically been used therapeutically and are known to be weak inhibitors of PDE, but to what extent this ...
Boswell-Smith, V, Spina, D, Page, C P
openaire   +3 more sources