Results 11 to 20 of about 225,115 (385)

Clinical Implication of Phosphodiesterase-4-Inhibition

International Journal of Molecular Sciences, 2022
The pleiotropic function of 3′,5′-cyclic adenosine monophosphate (cAMP)-dependent pathways in health and disease led to the development of pharmacological phosphodiesterase inhibitors (PDE-I) to attenuate cAMP degradation.
M. Schick, N. Schlegel
semanticscholar   +1 more source

The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors

Andrology, 2022
Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first‐line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data suggest that diabetic men may be ...
A. Cayetano-Alcaraz, T. Tharakan, Runzhi Chen, N. Sofikitis, S. Minhas   +4 more
semanticscholar   +1 more source

Difamilast, a selective phosphodiesterase 4 inhibitor, ointment in paediatric patients with atopic dermatitis: a phase III randomized double‐blind, vehicle‐controlled trial

British Journal of Dermatology, 2021
In atopic dermatitis (AD), phosphodiesterase 4 (PDE4) inhibition reduces proinflammatory mediators and cytokines. Difamilast is a new selective PDE4 inhibitor.
H. Saeki, N. Baba, K. Ito, D. Yokota, H. Tsubouchi   +4 more
semanticscholar   +1 more source

Compartmentation of cGMP Signaling in Induced Pluripotent Stem Cell Derived Cardiomyocytes during Prolonged Culture

Cells, 2022
The therapeutic benefit of stimulating the cGMP pathway as a form of treatment to combat heart failure, as well as other fibrotic pathologies, has become well established.
Maria Faleeva, Ivan Diakonov, Prashant Srivastava, Masoud Ramuz, Gaia Calamera, Kjetil Wessel Andressen, Nadja Bork, Lorenza Tsansizi, Marie-Victoire Cosson, Andreia Sofia Bernardo, Viacheslav Nikolaev, Julia Gorelik   +11 more
doaj   +1 more source

Phosphodiesterases in neurodegenerative disorders [PDF]

IUBMB Life, 2012
AbstractCyclic nucleotide phosphodiesterases (PDEs) are responsible for the breakdown of cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). As such, they are crucial regulators of levels of cyclic nucleotide‐mediated signaling.
Jos Prickaerts, Eva Bollen
openaire   +3 more sources

Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis

Frontiers in Molecular Biosciences, 2023
Acrodysostosis represents a group of rare genetic disorders characterized by defective skeletal development and is often accompanied by intellectual disabilities.
Varun Venkatakrishnan, Abhijeet Ghode, Nikhil K. Tulsian, Ganesh S. Anand, Ganesh S. Anand   +4 more
doaj   +1 more source

Cyclic-di-AMP Phosphodiesterase Elicits Protective Immune Responses Against Mycobacterium tuberculosis H37Ra Infection in Mice

Frontiers in Cellular and Infection Microbiology, 2022
Many antigens from Mycobacterium tuberculosis (M. tuberculosis) have been demonstrated as strong immunogens and proved to have application potential as vaccine candidate antigens. Cyclic di-AMP (c-di-AMP) as a bacterial second messenger regulates various
Yanzhi Lu, Huanhuan Ning, Jian Kang, Guangchun Bai, Lei Zhou, Yali Kang, Zhengfeng Wu, Maolin Tian, Junhao Zhao, Yueyun Ma, Yueyun Ma, Yinlan Bai   +11 more
doaj   +1 more source

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

Frontiers in Pharmacology, 2018
Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. Inhibition of PDE4 is predicted to have diverse effects
Heng Li, Jian-Ping Zuo, Wei Tang
semanticscholar   +1 more source

The low KM-phosphodiesterase inhibitor denbufylline enhances neuronal excitability in guinea pig hippocampus in vitro [PDF]

, 1990
The actions of the phosphodiesterase inhibitor denbufylline on the excitability of hippocampal neurons were investigated by means of extracellular and intracellular recordings.
Alzheimer, Christian, Ameri, A., Sutor, Bernd, Ten Bruggencate, Gerrit   +3 more
core   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source