Results 201 to 210 of about 96,537 (297)

Sildenafil effect on testosterone-induced prostate hypertrophy and relaxation of urinary bladder neck muscles. [PDF]

Toxicol Rep
El-Dwairi QA, Alzoubi KH, Mahafdeh R.
europepmc   +1 more source

Isolation and characterization of PDE-I and II, the inhibitors of cyclic adenosine-3',5'-monophosphate phosphodiesterase.

, 1978
Yûji Enomoto, Yoshio Furutani, HIROSHI NAGANAWA, MASA HAMADA, TOMIO TAKEUCHI, HAMAO UMEZAWA   +5 more
openalex   +2 more sources

Systemic treatment of immune checkpoint inhibitor‐induced psoriasis: Inference‐based guidance

Journal of the European Academy of Dermatology and Venereology, EarlyView.
When managing psoriasis, induced or exacerbated by ICI therapy for cancer, there are concerns regarding immunosuppression from systemic agents for the treatment of psoriasis and the potential impact on ICI efficacy. No direct, high‐level evidence exists to address these concerns.
Kim A. Papp, Luis Puig, Jennifer Beecker, Vinod Chandran, Joël Claveau, Javier Cortés, Jan Dutz, Noah I. Hornick, Rosalyn A. Juergens, Barbara Melosky, Anisha B. Patel, Maxwell B. Sauder, Sandeep Sehdev, Vincent Sibaud, Stephanie L. Snow   +14 more
wiley   +1 more source

An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping. [PDF]

Commun Chem
Wen J, Zhang C, Chen X, Dai Z, Li M, Ma W, Yam C, Huang X, Xiong C, Mei H.   +9 more
europepmc   +1 more source

Efficacy and safety of ME3183, an oral phosphodiesterase 4 inhibitor, in patients with plaque psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
We assessed four different doses of ME3183, a novel phosphodiesterase 4 inhibitor, and placebo in 132 patients with moderate to severe plaque psoriasis. At Week 16, more patients receiving ME3183 achieved ≥75% reduction in baseline Psoriasis Area and Severity Index scores than those receiving placebo, with no new safety concerns.
Kim A. Papp, April W. Armstrong, Tomokazu Koresawa, Kazunari Otake, Masayuki Hirata, Akiko Kano   +5 more
wiley   +1 more source

Molecular Approaches to Treating Chronic Obstructive Pulmonary Disease: Current Perspectives and Future Directions. [PDF]

Int J Mol Sci
Vu SP, Veit K, Sadikot RT.
europepmc   +1 more source

Mechanism of Activation of a Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase from Bovine Heart by Calcium Ions

, 1973
Tian Seng Teo, Jerry H. Wang
openalex   +1 more source

Xanthine Derivative KMUP‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis

Journal of Periodontal Research, EarlyView.
This study reveals that our self‐developed xanthine derivative, KMUP‐3, suppresses osteoclastogenesis, inflammation, and pyroptosis by inhibiting the NLRP3 inflammasome. It also alleviates periodontal bone loss in periodontitis rats, highlighting its potential as a novel therapeutic option for periodontitis.
Shang‐En Huang, Kai‐Fang Hu, Meng‐Xuan Lin, Ching‐Jiunn Tseng, Bin‐Nan Wu, Zen‐Kong Dai, Jong‐Hau Hsu, Jwu‐Lai Yeh   +7 more
wiley   +1 more source

Correction for Singh et al., Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen. [PDF]

Sci Rep
Zhao XZ, Wang W, Suazo KF, Al Mahmud MR, Agama K, Lountos GT, Andresson T, Pommier Y, Burke TR.   +8 more
europepmc   +1 more source