Results 51 to 60 of about 225,115 (385)

Saprotrophic and Ectomycorrhizal Fungi Contribute Differentially to Organic P Mobilization in Beech-Dominated Forest Ecosystems

Frontiers in Forests and Global Change, 2020
Phosphorus (P) is an essential nutrient, but European forest ecosystems are experiencing widespread declines in soil P concentrations. To clarify the roles of ectomycorrhizal (EM) and saprotrophic (SAP) fungi in P cycling in forest soils that differ in ...
Karolin Müller, Nadine Kubsch, Sven Marhan, Paula Mayer-Gruner, Pascal Nassal, Dominik Schneider, Rolf Daniel, Hans-Peter Piepho, Andrea Polle, Ellen Kandeler   +9 more
doaj   +1 more source

Phosphodiesterases in the Vascular System.

Journal of Smooth Muscle Research, 2003
Cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) are second messengers involved in the intracellular signal transduction of a variety of extracellular stimuli in several tissues. In the vascular system, these nucleotides play important roles in the regulation of vascular tone and in the maintenance of the ...
Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata   +2 more
openaire   +4 more sources

Correlates of Plasma NT‐proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity.
Leonard Chiu, Vineet Agrawal, David Armstrong, Evan Brittain, Sheila Collins, Anna R. Hemnes, Joseph A. Hill, JoAnn Lindenfeld, Sanjiv J. Shah, Lynne W. Stevenson, Thomas J. Wang, Deepak K. Gupta   +11 more
doaj   +1 more source

DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1 [PDF]

, 2007
DNA single-strand breaks (SSBs) are the commonest DNA lesions arising spontaneously in cells, and if not repaired may block transcription or may be converted into potentially lethal/clastogenic DNA double-strand breaks (DSBs).
Arnaudeau, Avemann, Barzilai, Bendixen, Caldecott, Caldecott, Cheng, Chrencik, Christiansen, Clements, Connelly, Culmsee, Daroui, Date, Davies, Davies, Davies, de Boer, Deng, D’Arpa, El-Khamisy, Flangas, Furuta, Godthelp, Hinz, Holm, Horwitz, Hsiang, Inamdar, Interthal, Interthal, Interthal, K.W. Caldecott, Kroeger, Lanza, Lesher, Liao, Lindahl, Liu, Mol, Moreira, Morris, Nitiss, Nouspikel, O’Driscoll, Parsons, Plo, Pommier, Pommier, Pommier, Poot, Pouliot, Pouliot, Pourquier, Pourquier, Pourquier, Pourquier, Pourquier, Rideout, Ryan, Ryan, S.F. El-Khamisy, Sarkander, Sarkander, Shao, Stewart, Strumberg, Takashima, Taylor, Thompson, van Waardenburg, Vance, Vidal, Vierck, Wang, Whitehouse, Wilson, Wu, Wu, Yan, Yang, Zhou, Zhou   +82 more
core   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Phosphodiesterases 4B and 4D Differentially Regulate cAMP Signaling in Calcium Handling Microdomains of Mouse Hearts

Cells
The ubiquitous second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling (ECC) by signaling in discrete subcellular microdomains.
Axel E. Kraft, Nadja I. Bork, Hariharan Subramanian, Nikoleta Pavlaki, Antonio V. Failla, Bernd Zobiak, Marco Conti, Viacheslav O. Nikolaev   +7 more
doaj   +1 more source

Eukaryotic-type Ser/Thr protein kinase mediated phosphorylation of mycobacterial phosphodiesterase affects its localization to the cell wall

Frontiers in Microbiology, 2016
Phosphodiesterase enzymes, involved in cAMP hydrolysis reaction, are present throughout phylogeny and their phosphorylation mediated regulation remains elusive in prokaryotes.
Neha eMalhotra, Pradip K Chakraborti
doaj   +1 more source

Phosphodiesterase induction in Dictyostelium discoideum by inhibition of extracellular phosphodiesterase activity [PDF]

Developmental Biology, 1982
Adenosine 3’,5’-monophosphate (cAMP) is a chemoattractant in Dictyostelium discoideum; it also induces phosphodiesterase activity. Recently it was shown that N’-(aminohexyl)adenosine 3’,5’-monophosphate (hexyl-cAMP) effectively induced phosphodiesterase activity, while this compound was chemotactically inactive and did not effectively bind to the cell ...
Peter J.M. van Haastert, Willem Bijleveld, Theo M. Konijn   +2 more
openaire   +4 more sources

Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor

Annals of the Rheumatic Diseases, 2014
Objectives Apremilast, an oral phosphodiesterase 4 inhibitor, regulates inflammatory mediators. Psoriatic Arthritis Long-term Assessment of Clinical Efficacy 1 (PALACE 1) compared apremilast with placebo in patients with active psoriatic arthritis ...
A. Kavanaugh, P. Mease, J. Gómez-Reino, A. Adebajo, J. Wollenhaupt, D. Gladman, E. Lespessailles, S. Hall, M. Hochfeld, ChiaChi Hu, D. Hough, R. Stevens, G. Schett   +12 more
semanticscholar   +1 more source

c-di-GMP Regulates Various Phenotypes and Insecticidal Activity of Gram-Positive Bacillus thuringiensis

Frontiers in Microbiology, 2018
C-di-GMP has been well investigated to play significant roles in the physiology of many Gram-negative bacteria. However, its effect on Gram-positive bacteria is less known.
Yang Fu, Zhaoqing Yu, Shu Liu, Bo Chen, Li Zhu, Zhou Li, Shan-Ho Chou, Jin He   +7 more
doaj   +1 more source