Results 51 to 60 of about 93,838 (303)

A Dose-Ranging Study of the Novel Inhaled Dual PDE 3 and 4 Inhibitor Ensifentrine in Patients with COPD Receiving Maintenance Tiotropium Therapy

International Journal of COPD, 2021
Gary T Ferguson,1 Edward M Kerwin,2 Tara Rheault,3 Thomas Bengtsson,4 Kathleen Rickard3 1Pulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, USA; 2Altitude Clinical Consulting, Medford, OR, USA; 3Verona Pharma, Plc, Raleigh, NC, USA;
Ferguson GT, Kerwin EM, Rheault T, Bengtsson T, Rickard K   +4 more
doaj  

Pregnancy Outcomes of Targeted Synthetic Disease‐Modifying Antirheumatic Drugs Among Patients With Autoimmune Diseases: A Scoping Review

Arthritis Care &Research, EarlyView.
Objective Targeted synthetic disease‐modifying antirheumatic drugs (tsDMARDs) have expanded the management of autoimmune diseases, including rheumatic diseases. As the use of these drugs grows, it is important to understand their effects on pregnancy.
Vienna Cheng, Neda Amiri, Vicki Cheng, Ursula Ellis, Jacquelyn J. Cragg, Mark Harrison, Laurie Proulx, Mary A. De Vera   +7 more
wiley   +1 more source

Modeling Suggests Combined-Drug Treatments for Disorders Impairing Synaptic Plasticity via Shared Signaling Pathways [PDF]

arXiv, 2020
Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharmacological therapies be suggested to improve learning and memory in these disorders?
arxiv  

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Pickering Emulsion for Enhanced Viability of Plant Growth Promoting Bacteria and Combined Delivery of Agrochemicals and Biologics

Advanced Functional Materials, EarlyView.
Cellulosic emulsions as multi‐cargo agriculture formulations. Pickering emulsions stabilized by cellulose acetate particles provide an effective platform for delivering a range of agricultural cargoes, including plant growth‐promoting bacteria and agrochemicals.
Mariam Sohail, John Cheadle, Rishum Khan, Hrishikesh Mane, Khandoker Samaher Salem, Katie Ernst, Adriana San Miguel, Charles H. Opperman, Tahira Pirzada, Nathan Crook, Saad A. Khan   +10 more
wiley   +1 more source

Are β3‐adrenoceptor gene polymorphisms relevant for urology?

Neurourology and Urodynamics, Volume 42, Issue 1, Page 33-39, January 2023., 2023
Abstract Aims β3‐adrenoceptors (ARs) are an important drug target for the treatment of overactive bladder syndrome (OAB) and are under investigation for other indications. The human β3‐AR gene is polymorphic; an exchange of amino acid tryptophan (Trp) for arginine (Arg) in position 64 of the receptor protein is the most frequent and best‐studied ...
Martin C. Michel
wiley   +1 more source

Phosphodiesterase 3A and Arterial Hypertension [PDF]

Circulation, 2020
Background: High blood pressure is the primary risk factor for cardiovascular death worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt-resistant essential hypertension and causes death by stroke before 50 years of age. We recently implicated the gene encoding phosphodiesterase
Hanna Napieczynska, Michael Russwurm, Martin Lehmann, Astrid Mühl, Yingqiu Cui, Sofia K. Forslund, Stefanie Schelenz, Kerstin Zühlke, Rosana Molé Illas, Reika Langanki, Russell Hodge, Stephan Walter, Theda U P Bartolomaeus, Theda U P Bartolomaeus, Carolin Schächterle, Burkhard Wiesner, Nerine Gregersen, Sylvia Bähring, Ilona Kamer, Maria Ercu, Mihail Todiras, Friedrich C. Luft, Dmitry Tsvetkov, Arnd Heuser, Bärbel Pohl, Ralph Plehm, Elena Popova, Martin Taube, Jenny Eichhorst, Maik Gollasch, Maik Gollasch, Maik Gollasch, Fatimunnisa Qadri, Lajos Markó, Lajos Markó, Enno Klussmann, Michael Bader, Michael Bader, Yoland-Marie Anistan, Norbert Hubner, Norbert Hubner, Andrea Geelhaar, Sara Maghsodi, Atakan Aydin, Dominik N. Müller, Philipp G. Maass   +45 more
openaire   +3 more sources

Endothelial PD‐1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development

Advanced Science, EarlyView.
Vascular endothelial cells are fundamental for angiogenesis and brain development. This study reveals that endothelial programmed cell death 1 (PD‐1) is critical for cerebral angiogenesis and blood brain barrier (BBB) maturation. It also mediates interaction with oligodendrocyte precursor cells (OPCs), modulating OPCs differentiation and myelination ...
Tingting He, Mengtian Zhang, Jie Qin, Yanyan Wang, Sihan Li, Chaoyi Du, Jianwei Jiao, Fen Ji   +7 more
wiley   +1 more source

Phosphodiesterase-4 Inhibitors for Non-COPD Respiratory Diseases

Frontiers in Pharmacology, 2021
Selective phosphodiesterase (PDE) inhibitors are a class of nonsteroid anti-inflammatory drugs for treating chronic inflammatory diseases. Modulation of systemic and airway inflammation is their pivotal mechanism of action.
Theerasuk Kawamatawong
doaj   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source