Results 171 to 180 of about 47,423 (289)

Compound Xuanju capsules combined with phosphodiesterase-5 inhibitors as a new strategy for erectile dysfunction: a meta-analysis and trial sequential analysis. [PDF]

Front Pharmacol
Li R, Liao M, Yu Y, Guo B, Yu R, He Q, Zhang G.   +6 more
europepmc   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Molecular Dynamics-Assisted Discovery of Novel Phosphodiesterase-5 Inhibitors Targeting a Unique Allosteric Pocket. [PDF]

Molecules
Luo W, Liu R, Cai X, Zhou Q, Zhang C.
europepmc   +1 more source

Effect of Phosphodiesterase-5 Inhibitors on the Treatment of Male Infertility: A Systematic Review and Meta-Analysis. [PDF]

World J Mens Health, 2021
Dong L, Zhang X, Yan X, Shen Y, Li Y, Yu X.   +5 more
europepmc   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

A Brief Overview of Cholinergic and Phosphodiesterase-5 Inhibitors in Diabetic Bladder Dysfunction. [PDF]

Int J Mol Sci
Kallinikas G, Haronis G, Kallinika E, Kozyrakis D, Rodinos E, Filios A, Filios P, Mityliniou D, Safioleas K, Zarkadas A, Bozios D, Karmogiannis A, Konstantinopoulos V, Konomi AM, Ektesabi AM, Tsoporis JN.   +15 more
europepmc   +1 more source

Association of Phosphodiesterase-5 Inhibitor Treatment With Improved Survival in Pulmonary Hypertension Associated With COPD in the Pulmonary Vascular Research Institute GoDeep Meta-Registry [PDF]

Khodr Tello, Athiththan Yogeswaran, Raphael W. Majeed, David G. Kiely, Allan Lawrie, Evan L. Brittain, Jeffrey Annis, Horst Olschewski, Gábor Kovács, Paul M. Hassoun, Aparna Balasubramanian, Ziad Konswa, Andrew J. Sweatt, Roham T. Zamanian, Martin R. Wilkins, Luke Howard, Alexandra Arvanitaki, George Giannakoulas, Héctor Cajigas, Robert P. Frantz, Paul G Williams, Marlize Frauendorf, Kurt Marquardt, Tobiah Antoine, Meike Fuenderich, Manuel J. Richter, Friedrich Grimminger, Hossein Ardeschir Ghofrani, Jochen Wilhelm, Werner Seeger   +29 more
openalex   +1 more source

EDEUS, a Real-Life Study on the Users of Phosphodiesterase Type 5 Inhibitors: Prevalence, Perceptions, and Health Care-Seeking Behavior Among European Men With a Focus on 2nd-Generation Avanafil [PDF]

, 2017
Giovanni Corona, Mario Maggi, Emmanuele A. Jannini   +2 more
openalex   +1 more source

Phosphodiesterase-5 inhibitor sildenafil attenuates kidney injury induced by Bothrops alternatus snake venom

, 2021
Antônio Rafael Coelho Jorge, Aline Diogo Marinho, João Alison de Moraes Silveira, Francisco Assis Nogueira Júnior, Peter Aquino, Ana Paula Negreiros Nunes Alves, Roberta Jeane Bezerra Jorge, Rui Seabra Ferreira, Helena Serra Azul Monteiro   +8 more
openalex   +2 more sources

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source