Results 81 to 90 of about 47,423 (289)

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Analyzing food supplements to enhance erectile system function for the presence of undeclared sildenafil and tadalafil using HPLC-DAD [PDF]

Journal of the Serbian Chemical Society
Phosphodiesterase-5 (PDE-5) inhibitors, such as sildenafil and tadalafil, are drugs commonly used to improve erectile function. However, some erectile function-enhancing supplements with claims of being entirely natural may be adulterated with these ...
Bozhinoska Zorica, Zhivikj Zoran, Ubavkova Stefanija, Bujaroska-Perkovikj Marija, Poposka Verica, Stankov Aleksandar, Petreska-Ivanovska Tanja   +6 more
doaj   +1 more source

Oral phosphodiesterase-5 inhibitors and sperm functions [PDF]

International Journal of Impotence Research, 2008
This review aims to elucidate the possible effects of phosphodiesterase-5 (PDE5) inhibitors on sperm functions. PDEs hydrolyze cyclic nucleotides, and together with adenylyl and guanylyl cyclase, which catalyze the formation of cAMP and cGMP, regulate the levels of these second messengers in cells.
openaire   +2 more sources

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Sexual function in hypertensive patients receiving treatment

Vascular Health and Risk Management, 2006
Thorsten Reffelmann, Robert A KlonerUniversity of Southern California, The Heart Institute, Good Samaritan Hospital, Division of Cardiovascular Medicine, Keck School of Medicine, Los Angeles, CA, USAAbstract: In many forms of erectile dysfunction (ED ...
Thorsten Reffelmann, Robert A Kloner
doaj  

Inhibition of PDE5 restores depressed baroreflex sensitivity in renovascular hypertensive rats

Frontiers in Physiology, 2016
Renal artery stenosis is frequently associated with resistant hypertension, which is defined as failure to normalize blood pressure (BP) even when combined drugs are used.
Clenia O Cavalcanti, Rafael R Alves, Rafael R Alves, Alessandro L Oliveira, Alessandro L Oliveira, JOSIANE CAMPOS CRUZ, Maria Socorro França-Silva, Valdir Andrade Braga, Camille M Balarini, Camille M Balarini   +9 more
doaj   +1 more source

Phosphodiesterase-5 inhibitors and the heart: compound cardioprotection? [PDF]

, 2018
David Hutchings, Simon Anderson, Jessica L. Caldwell, Andrew W. Trafford   +3 more
openalex   +1 more source

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, EarlyView.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Endothelial Dysfunction, Erectile Dysfunction and Phosphodiesterase 5 Inhibitors. An Update of the Current Data and Future Perspectives

Drug Target Insights, 2007
Endothelial dysfunction is a pathological entity that multiply affects the health status. Erectile dysfunction is being recognized as a condition that is strongly interrelated with endothelial dysfunction, being a vascular event itself.
Angelis Konstantinopoulos, Konstantinos Giannitsas, Spiros Raptis, Petros Perimenis   +3 more
doaj