Results 31 to 40 of about 2,886,292 (384)

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease [PDF]

, 2013
The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells.
Brunton, Donald H Maurice, Dreiza, George S Baillie, Hayes, Li, Louisa CY Lee, Shenoy, Tavalin   +8 more
core   +1 more source

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

Human Reproduction, 2014
STUDY QUESTION Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions? SUMMARY ANSWER We have identified
S. Tardif, Oladipo A. Madamidola, Sean G Brown, Lorna Frame, L. Lefièvre, P. Wyatt, C. Barratt, S. J. Martins da Silva   +7 more
semanticscholar   +1 more source

Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory [PDF]

, 2016
Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial ...
Abel, Ted, Baillie, George W., Bruinenberg, Vibeke M., Guercio, Leonardo A., Hansen, Rolf T., Havekes, Robbert, Houslay, Miles D., Lee, Yool, Linton, Edward, Meerlo, Peter, Neves, Susana R., Park, Alan J., Tolentino, Rosa E., Tudor, Jennifer C.   +13 more
core   +4 more sources

Prevention of the development of heart failure with preserved ejection fraction by the phosphodiesterase‐5A inhibitor vardenafil in rats with type 2 diabetes

European Journal of Heart Failure, 2016
Heart failure with preserved ejection fraction (HFpEF) has a great epidemiological burden. The pathophysiological role of cyclic guanosine monophosphate (cGMP) signalling has been intensively investigated in HFpEF. Elevated levels of cGMP have been shown
C. Mátyás, B. Németh, A. Oláh, Marianna Török, M. Ruppert, D. Kellermayer, B. Barta, G. Szabó, G. Kökény, E. Horváth, B. Bódi, Z. Papp, B. Merkely, T. Radovits   +13 more
semanticscholar   +1 more source

Editorial [PDF]

, 2016
No abstract ...
Baillie, George S.
core   +1 more source

Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]

, 1998
Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F., Walikonis, Randall S.   +1 more
core   +1 more source

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Synthesis, Tyrosinase Inhibiting Activity and Molecular Docking of Fluorinated Pyrazole Aldehydes as Phosphodiesterase Inhibitors

Applied Sciences, 2019
A series of fluorinated 4,5-dihydro-1H-pyrazole derivatives were synthesized in the reaction of corresponding acetophenone and different aldehydes followed by the second step synthesis of desired compounds from synthesized chalcone, hydrazine hydrate ...
Vesna Rastija, Harshad Brahmbhatt, Maja Molnar, Melita Lončarić, Ivica Strelec, Mario Komar, Valentina Pavić   +6 more
doaj   +1 more source

Apremilast, an oral phosphodiesterase 4 inhibitor, improves patient‐reported outcomes in the treatment of moderate to severe psoriasis: results of two phase III randomized, controlled trials

Journal of the European Academy of Dermatology and Venereology, 2016
Apremilast, an oral phosphodiesterase 4 inhibitor, has an acceptable safety profile and is effective for treatment of plaque psoriasis and psoriatic arthritis.
D. Thaçi, Alexa B. Kimball, P. Foley, Y. Poulin, E. Levi, Rongdean Chen, S. Feldman   +6 more
semanticscholar   +1 more source

New Avenues for Phosphodiesterase Inhibitors in Asthma

Journal of Experimental Pharmacology, 2021
Phosphodiesterases (PDEs) are isoenzymes ubiquitously expressed in the lungs where they catalyse cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (GMP), which are fundamental second messengers in asthma, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signaling pathways and, consequently ...
Maria Gabriella Matera, Josuel Ora, Francesco Cavalli, Paola Rogliani, Mario Cazzola   +4 more
openaire   +8 more sources