Results 1 to 10 of about 2,881,835 (365)

New Avenues for Phosphodiesterase Inhibitors in Asthma [PDF]

Journal of Experimental Pharmacology, 2021
Maria Gabriella Matera,1 Josuel Ora,2 Francesco Cavalli,2 Paola Rogliani,2,3 Mario Cazzola3 1Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Respiratory Diseases Unit, “Tor Vergata&rdquo ...
Matera MG, Ora J, Cavalli F, Rogliani P, Cazzola M   +4 more
doaj   +9 more sources

Phosphodiesterase Inhibitors: Could They Be Beneficial for the Treatment of COVID-19? [PDF]

Int J Mol Sci, 2020
In March 2020, the World Health Organization declared the severe acute respiratory syndrome corona virus 2 (SARS-CoV2) infection to be a pandemic disease. SARS-CoV2 was first identified in China and, despite the restrictive measures adopted, the epidemic
Giorgi M, Cardarelli S, Ragusa F, Saliola M, Biagioni S, Poiana G, Naro F, Massimi M.   +7 more
europepmc   +2 more sources

Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale. [PDF]

J Alzheimers Dis Rep, 2020
Background: Preclinical studies, clinical trials, and reviews suggest increasing 3’,5’-cyclic adenosine monophosphate (cAMP) and 3’,5’-cyclic guanosine monophosphate (cGMP) with phosphodiesterase inhibitors is disease-modifying in Alzheimer’s disease (AD)
Sanders O, Rajagopal L.
europepmc   +2 more sources

Respiratory Cilia as a Therapeutic Target of Phosphodiesterase Inhibitors. [PDF]

Front Pharmacol, 2020
Mucociliary clearance is an essential airway defense mechanism dependent predominantly on the proper ciliary function and mucus rheology. The crucial role of cilia is evident in `a variety of respiratory diseases, as the ciliary dysfunction is associated
Joskova M, Mokry J, Franova S.
europepmc   +2 more sources

Therapeutic Potential of Phosphodiesterase Inhibitors against Neurodegeneration: The Perspective of the Medicinal Chemist. [PDF]

ACS Chem Neurosci, 2020
Increasing human life expectancy prompts the development of novel remedies for cognitive decline: 44 million people worldwide are affected by dementia, and this number is predicted to triple by 2050.
Ribaudo G, Ongaro A, Zagotto G, Memo M, Gianoncelli A.   +4 more
europepmc   +2 more sources

Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19). [PDF]

Cureus, 2020
Effective treatments for Coronavirus Disease 2019 (COVID-19) outbreak are urgently needed. While anti-viral approaches and vaccines are being considered immediate countermeasures are unavailable. The aim of this article is to outline a perspective on the
Solaimanzadeh I.
europepmc   +2 more sources

The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2017
Agents that augment cerebral blood flow (CBF) could be potential treatments for vascular cognitive impairment. Phosphodiesterase-5 inhibitors are vasodilating drugs established in the treatment of erectile dysfunction (ED) and pulmonary hypertension.
M. Pauls, B. Moynihan, T. Barrick, C. Kruuse, J. Madigan, A. Hainsworth, J. Isaacs   +6 more
semanticscholar   +3 more sources

Potential synergistic effect of phosphodiesterase inhibitors with chemotherapy in lung cancer. [PDF]

J Cancer, 2017
Purpose: Lung cancer remains the leading cause of cancer-related deaths worldwide and novel therapeutic approaches targeting crucial pathways are urgently needed to improve its treatment.
Domvri K, Zarogoulidis K, Zogas N, Zarogoulidis P, Petanidis S, Porpodis K, Kioseoglou E, Hohenforst-Schmidt W.   +7 more
europepmc   +2 more sources

Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair. [PDF]

Int J Mol Sci, 2017
A wide diversity of perturbations of the central nervous system (CNS) result in structural damage to the neuroarchitecture and cellular defects, which in turn are accompanied by neurological dysfunction and abortive endogenous neurorepair.
Knott EP, Assi M, Rao SN, Ghosh M, Pearse DD.   +4 more
europepmc   +2 more sources

Effect of phosphodiesterase inhibitors on platelet function [PDF]

Biochemistry and Biophysics Reports
Phosphodiesterase enzymes (PDEs) play a pivotal role in regulating platelet activity by modulating intracellular levels of cAMP and cGMP. Modulation of PDE-2, -3 and -5 activity by suitable inhibitors has been found to reduce platelet activity, and thus ...
Ravi Hochuli, Valerie Dicenta, Zoi Laspa, Manuel Sigle, Tobias Harm, Tatsiana Castor, Anne-Katrin Rohlfing, Meinrad Paul Gawaz   +7 more
doaj   +2 more sources