Results 131 to 140 of about 86,123 (283)

Sympatho‐Excitation in Pulmonary Hypertension: The Potential Role of Pulmonary Arterial Baroreceptors: An Acute Physiologic Intervention Study

Respirology, EarlyView.
Pulmonary arterial baroreceptors reflexively stimulate sympathetic nerve activity (SNA) in response to elevated pulmonary artery pressure and distension. In pulmonary hypertension patients, changes in muscle SNA were proportional to changes in pulmonary haemodynamics following nebulised iloprost.
Michael J. Plunkett, Ana L. C. Sayegh, Robert A. Lewis, Tanya J. McWilliams, Sasiharan Sithamparanathan, Julian F. R. Paton, James P. Fisher   +6 more
wiley   +1 more source

Erectile and ejaculatory outcomes after holmium laser enucleation of the prostate: A comprehensive narrative review

UroPrecision, EarlyView.
ABSTRACT Holmium laser enucleation of the prostate (HoLEP) has emerged as a widely adopted surgical technique for the management of benign prostatic hyperplasia (BPH), regardless of prostate size; however, its impact on male sexual function—particularly in terms of erectile and ejaculatory outcomes—remains a subject of ongoing debate.
Muhammed Arif İbiş, Fabio Castiglione, Nawal Khan, Ömer Onur Çakır, Zafer Tokatlı, Önder Yaman   +5 more
wiley   +1 more source

Inhibition of Colon Cancer Cell Growth by Phosphodiesterase Inhibitors Is Independent of cGMP Signaling. [PDF]

J Pharmacol Exp Ther, 2022
Hou Y, Wren A, Mylarapu N, Browning K, Islam BN, Wang R, Vega KJ, Browning DD.   +7 more
europepmc   +1 more source

Penile traction therapy after radical pelvic surgery: Does it work?

UroPrecision, EarlyView.
Abstract Sexual dysfunction, including erectile dysfunction and penile shortening, is a frequent consequence of radical pelvic surgeries such as prostatectomy, cystoprostatectomy, and rectal cancer surgery. These complications primarily result from nerve injury and hypoxia‐induced corporal fibrosis.
Ahmet Tevfik Albayrak, Mustafa Faruk Usta   +1 more
wiley   +1 more source

Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis. [PDF]

J Pharmacol Exp Ther, 2022
Świerczek A, Pomierny B, Wyska E, Jusko WJ.   +3 more
europepmc   +1 more source

Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]

, 1994
Forssmann, W. G., Jonas, Udo, Meyer, M. F., Schulz-Knappe, P., Stief, Christian Georg, Taher, A., Truss, Michael C.   +6 more
core   +1 more source

Supersonic transporter (SST) deformity of penile prosthesis: Current management strategies

UroPrecision, EarlyView.
Abstract Supersonic transporter (SST) deformity, also known as floppy glans syndrome, represents a persistent source of post‐operative dissatisfaction among patients undergoing inflatable penile prosthesis (IPP) implantation. Although infection and mechanical failure rates have declined with advances in device design and surgical technique, SST ...
Mohammed Mahdi, Thairo A. Pereira, Muhammed A. M. Hammad   +2 more
wiley   +1 more source

Impacts of anti-inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation. [PDF]

Pharmacol Res Perspect, 2021
Zheng XF, Chen DD, Zhu XL, Le Grange JM, Zhou LQ, Zhang JN.   +5 more
europepmc   +1 more source

Penile rehabilitation in men after radical robotic prostatectomy: Fact or fiction?

UroPrecision, EarlyView.
Abstract Erectile dysfunction (ED) is one of the most frequent and distressing complications after radical prostatectomy (RP), significantly impairing patients’ quality of life and intimate relationships. Penile rehabilitation (PR) aims to preserve erectile tissue integrity, prevent fibrosis, and facilitate early functional recovery by restoring ...
Karen Zhang, Arnold P. P. Achermann, Hunter Hasley, Richard Bennett, Andrew Guo, Mohammed Mahdi, Lucas G. C. R. de Amorim, Helen L. Bernie, Thairo A. Pereira   +8 more
wiley   +1 more source

In silico exploration of antinociceptive activity of 1,4-benzodiazepines: Molecular docking on α1 A-adrenoceptor, and phosphodiesterase 4

Regulatory Mechanisms in Biosystems
Recently, scientists have established that several benzodiazepines were found to enhance the activation of a cAMP response element pathway by α1A-adrenergic receptors, but this effect was attributed to off-target inhibition of phosphodiesterases 4.
A. S. Akisheva, V. B. Larionov, M. Y. Golovenko, O. A. Makarenko, I. P. Valivodz, I. Y. Borysiuk, Y. O. Molodan   +6 more
doaj   +1 more source