Results 31 to 40 of about 86,123 (283)

The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review. [PDF]

, 2017
Agents that augment cerebral blood flow (CBF) could be potential treatments for vascular cognitive impairment. Phosphodiesterase-5 inhibitors are vasodilating drugs established in the treatment of erectile dysfunction (ED) and pulmonary hypertension.
Barrick, TR, Hainsworth, AH, Isaacs, JD, Kruuse, C, Madigan, JB, Moynihan, B, Pauls, MM   +6 more
core   +1 more source

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
A Dawn, A Heiber, A Merckx, A Pantaleo, A Sudo, AE Bianco, Audrey Lorthiois, Bernina Naissant, C Lavazec, C Lavazec, C Syin, Catherine Lavazec, CJ Taylor, D Yokoyama, DA Baker, David A. Baker, DK Muhia, Dominique Soldati-Favre, Donatella Taramelli, E Farfour, E Lasonder, E Ling, Eloise Thompson, F Hawking, F Silvestrini, F Silvestrini, Florence Breil, Florian Dupuy, G Deplaine, Ghania Ramdani, Gordon Langsley, HM Taylor, I Koshino, J Bain, K Leykauf, Kenneth Vernick, KM Tang, L Chen, L McRobert, L Wentzinger, LK Read, M Aingaran, M Boolell, M Hliscs, M Tiburcio, M Tiburcio, ME Smalley, MJ Lopez-Barragan, MK Dearnley, MW Dixon, N Goto, N Mohandas, Odile Mercereau-Puijalon, QL Fivelman, R Aguilar, R Joice, RE Sinden, RE Sinden, RL Coppel, Ross Cummings, RW Moon, S D'Alessandro, S Kunz, S Sanyal, SM Knebel, SP Davies, SP Kim, T Bousema, T Harrison, T Ono, T Seebeck, W Trager, WB Smith 2nd, Yoann Duffier, Yolanda Corbett   +74 more
core   +9 more sources

Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer

Nature Communications, 2020
Phosphodiesterase-5 (PDE5) inhibitors have been suggested to have an anti-tumor effect and block surgery-induced immunosuppression. Here, the authors show that postdiagnostic use of PDE5 inhibitors is associated with a decreased risk of colorectal ...
Wuqing Huang, Jan Sundquist, Kristina Sundquist, Jianguang Ji   +3 more
doaj   +1 more source

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]

, 2013
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz, Boyd, Breslin, Caldecott, Chen, Chiang, Ciccia, Dalhus, Das, Demple, Dungey, El-Khamisy, Fu, Godon, Hecht, Hegde, Hudson, Interthal, Interthal, Kato, Katyal, Kummar, Lebedeva, Lindahl, Lindahl, Liu, Loeb, Luo, Madhusudan, Meisenberg, Meryem Alagoz, Mohammed, Morland, Murai, Murai, Nilsen, Owen S. Wells, Pommier, Pourquier, Povirk, Ray Chaudhuri, Rydberg, Sherif F. El-Khamisy, Strom, Sultana, Takashima, Wilson, Xanthoudakis, Yang, Zeng, Zhou   +50 more
core   +1 more source

Benefits and risks of testosterone treatment for hypoactive sexual desire disorder in women: a critical review of studies published in the decades preceding and succeeding the advent of phosphodiesterase type 5 inhibitors

Clinics, 2014
With advancing age, there is an increase in the complaints of a lack of a libido in women and erectile dysfunction in men. The efficacy of phosphodiesterase type 5 inhibitors, together with their minimal side effects and ease of administration ...
Sandra Léa Bonfim Reis, Carmita H.N. Abdo   +1 more
doaj   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6- (3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one [PDF]

, 2018
Natural and semi-synthetic compounds are being studied as novel phosphodiesterase 5 (PDE5) inhibitors for the treatment of erectile dysfunction, pulmonary hypertension, and lower urinary symptoms.
Ongaro, Alberto, Ribaudo, Giovanni, Zagotto, Giuseppe   +2 more
core   +1 more source

Experimental Pharmacological Management of Psoriasis

Journal of Experimental Pharmacology, 2021
Elena Campione,1 Terenzio Cosio,1 Monia Di Prete,2 Caterina Lanna,1 Annunziata Dattola,1 Luca Bianchi1 1Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy; 2Anatomic Pathology, University of Rome Tor ...
Campione E, Cosio T, Di Prete M, Lanna C, Dattola A, Bianchi L   +5 more
doaj  

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian, Ong, Wee Kiat, Pyne, Nigel J.   +2 more
core   +1 more source