Results 241 to 250 of about 79,270 (300)

Emerging Regulatory Mechanisms in Sinoatrial Node Automaticity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT The sinoatrial node (SAN), the primary cardiac pacemaker, governs rhythmic heartbeats through spontaneous electrical impulses. While the classical “coupled‐clock” theory, integrating the membrane voltage clock (driven by cyclic ion channel activity) and the calcium clock (orchestrated by rhythmic sarcoplasmic reticulum Ca2+ release), remains ...
Hongyu Liu, Yuting Cao, Xuling Su
wiley   +1 more source

PDE10A as a novel diagnostic and therapeutic target in cancer: insights and challenges. [PDF]

Front Oncol
Ghoflchi S, Nakhaei A, Abbasinezhad-Moud F, Jalili-Nik M, Cimino PJ.   +4 more
europepmc   +1 more source

Role of solubile guanylyl cyclase 11 (SGC11) isoform in mice corpus cavernosum smooth muscle relaxation [PDF]

, 2007
Brouckaert, Peter, Buys, Emmanuel, Nimmegeers, Sofie, Sips, Patrick, Van de Voorde, Johan   +4 more
core  

Results from the 32‐week, phase 3 DISCREET study of apremilast in patients with moderate to severe genital psoriasis

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 274-284, February 2026.
During the extension phase of the 32‐week DISCREET trial, apremilast treatment in patients with moderate to severe genital psoriasis led to clinically meaningful improvements in disease severity (modified genital PGA, overall sPGA, BSA), symptoms (genital itch, GPSS), and quality of life (DLQI, DLQI‐Q9), with safety outcomes consistent with prior ...
Joseph F. Merola, Lyn Guenther, Charles Lynde, Kim A. Papp, Lawrence Charles Parish, Paul Yamauchi, Sue Cheng, Hamid Amouzadeh, Cynthia Deignan, Shauna Jardon, Mindy Chen, Andreas Pinter   +11 more
wiley   +1 more source

The impact of PDE5 inhibitors on cardiovascular outcomes. [PDF]

Glob Cardiol Sci Pract
Ghantous I, Tlais M, Khatib AE, Ghantous G, Maroun G, Challita A, Ayek M, Barmo G, Sahyoun M, El Kari G.   +9 more
europepmc   +1 more source

Intercellular diffusion of cyclic nucleotides followed by gap junction closure restarts meiosis in mouse preovulatory follicles. [PDF]

Proc Natl Acad Sci U S A
Nakashima IF, Zhong H, Nikolaev VO, Owen CM, Yee SP, Jaffe LA, Egbert JR.   +6 more
europepmc   +1 more source

Real-World Adherence and Persistence of Upfront Therapy in Patients with Pulmonary Arterial Hypertension in the United States. [PDF]

Pulm Ther
De Marco T, Paoli CJ, Croteau NS, Tang F, Farber HW.   +4 more
europepmc   +1 more source

The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Dyrkheeva NS, Chernyshova IA, Arutyunyan AF, Zakharenko AL, Kutuzov MM, Naumenko KN, Venzel AS, Ivanisenko VA, Deyev SM, Zhuze AL, Lavrik OI.   +10 more
europepmc   +1 more source

Phosphodiesterase Inhibition Increases Striatal GDNF and Protects Against Preclinical Parkinsonism. [PDF]

J Neurochem
d'Anglemont de Tassigny X, Jiménez-Medina A, López-López I, López-Barneo J.   +3 more
europepmc   +1 more source