Results 141 to 150 of about 69,283 (286)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis. [PDF]

Front Cardiovasc Med, 2022
Cao F, Wu K, Zhu YZ, Jiang JJ, Zhang G, Liu J, Xiao P, Tian Y, Zhang W, Zhang S, Hou F, Bao ZW.   +11 more
europepmc   +1 more source

Low testosterone levels in men at age 31 associates with future risk of prediabetes and type 2 diabetes: A birth cohort study

Andrology, EarlyView.
Abstract Objective We aimed to investigate the association of a low serum testosterone concentration with the risk of abnormal glucose metabolism (i.e., prediabetes and type 2 diabetes) in men at a 15‐year follow‐up. Study population and methods In a population birth cohort, men with low testosterone (testosterone < 12.1 nmol/L, n = 136) and normal ...
Tuomisto A, Pinola P, Pesonen P, Franks S, Martikainen H, Tapanainen JS, Niinimäki M, Morin‐Papunen L   +7 more
wiley   +1 more source

Polyglycolic Acid Polymer Versus Porcine Small Intestine Submucosa Graft After Plaque Incision in Peyronie's Disease: A Comparative Study

Andrology, EarlyView.
ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost, Leonardo Seligra Lopes, Pedro Caetano Edler Zandoná, Jovânio Fernandes da Rosa, Pedro Fernandes Lessa, Felipe Placco Araujo Glina, Nívio Pascoal Teixeira, Sidney Glina   +7 more
wiley   +1 more source

Combined therapy with dutasteride and tadalafil vs dutasteride or tadalafil monotherapy in benign prostatic hyperplasia: a randomised phase III trial

BJU International, EarlyView.
Objectives To evaluate the efficacy and safety of a fixed‐dose combination (FDC) of dutasteride and tadalafil vs monotherapy in patients with benign prostatic hyperplasia (BPH). Patients and Methods This phase III trial enrolled 667 patients. After screening and washout, eligible patients were stratified by the baseline International Prostate Symptom ...
Seung Wook Lee, Seung Hwan Lee, Jae Heon Kim, Joon Hwa Noh, Jun Ho Lee, U‐Syn Ha, Cheol Young Oh, Taek Won Kang, Gyeongseop Lee, Sangchul Lee, Deok Hyun Han, Jun Hyun Han, Sang Hoon Song, Hyun Jun Park, Byung Ha Chung, Gyeong Eun Min, In Gab Jeong, Kyung Hyun Moon, Won Tae Kim, Ji Youl Lee, Choung‐Soo Kim   +20 more
wiley   +1 more source

Efficacy and safety of PDE5 inhibitors in middle-aged and old patients with and without hypogonadism

The Aging Male
Purpose Although several reviews have evaluated the use of PDE5 inhibitors (PDE5i) for treating erectile dysfunction (ED), their specific use in middle-aged and old patients has not been fully evaluated.
Chunlin Wang, Hui Zhang, Fu Wang, Jun Guo, Jianlin Yuan, Guangdong Hou, Ming Gao, Zheng Li, Yan Zhang   +8 more
doaj   +1 more source

The Recruitment and Retention of Individuals With Intellectual Disability in Randomized Controlled Trials: A Scoping Review

British Journal of Learning Disabilities, EarlyView.
ABSTRACT Background People with intellectual disabilities face significant health disparities and often encounter barriers in accessing healthcare services. Although research supports the need for reasonable adjustments to improve healthcare access for this population, implementation in acute healthcare settings remains limited.
Owen Doody, Louise Murphy, Ruth Ryan, Rosemary Lyons, Wenyi Tang, Lorna Bourke   +5 more
wiley   +1 more source

Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro [PDF]

, 1994
Forssmann, W. G., Jonas, Udo, Meyer, M. F., Schulz-Knappe, P., Stief, Christian Georg, Taher, A., Truss, Michael C.   +6 more
core   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts. [PDF]

Cell Rep Med, 2022
Sharpe BP, Hayden A, Manousopoulou A, Cowie A, Walker RC, Harrington J, Izadi F, Breininger SP, Gibson J, Pickering O, Jaynes E, Kyle E, Saunders JH, Parsons SL, Ritchie AA, Clarke PA, Collier P, Mongan NP, Bates DO, Yacqub-Usman K, Garbis SD, Walters Z, Rose-Zerilli M, Grabowska AM, Underwood TJ.   +24 more
europepmc   +1 more source