Results 201 to 210 of about 17,985,271 (268)
Relation of phosphodiesterase type 5 inhibitors and malignant melanoma: a meta-analysis and systematic review. [PDF]
Oncotarget, 2017 Wang J +6 more
europepmc +1 more source
Comparison of phosphodiesterase type 5 (PDE5) inhibitors
International Journal of Clinical Practice, 2006 openaire +1 more source
Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management
MedComm, Volume 7, Issue 10, October 2026.A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley +1 more source
NMR in Biomedicine, Volume 39, Issue 10, October 2026.Metabolomic profiling of breast cancer tissue using 1H HR‐MAS NMR spectroscopy and LCModel‐based quantitative analysis revealed metabolite differences associated with immunohistochemical subtypes, and subsequent metabolomics–transcriptomics integration linked these subtype‐dependent metabolic signatures to pathways in choline metabolism, one‐carbon ...
Irene Garcia‐Bocanegra +10 more
wiley +1 more source
ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Marco Tozzi +8 more
wiley +1 more source
Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?
Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley +1 more source
Function drives 1‐year decision regret in radical prostatectomy: a multicentre prospective study
BJU International, Volume 138, Issue 4, Page 694-704, October 2026.Objectives To identify contemporary drivers of postoperative decision regret 1 year after radical prostatectomy (RP). Patients and Methods In this prospective, multicentre study, patients undergoing robot‐assisted RP (RARP) or retropubic open RP (ORP) for localised prostate cancer at seven centres in Germany and Austria (2022–2024) completed ...
Christopher Hirtsiefer +14 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó +14 more
wiley +1 more source
PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation
International Journal of Dermatology, Volume 65, Issue 10, Page 2038-2048, October 2026.This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad +2 more
wiley +1 more source
E3 Ubiquitin Ligases in MASH‐Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities
Liver International, Volume 46, Issue 10, October 2026.ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a major cause of progressive liver fibrosis and can ultimately lead to cirrhosis and hepatocellular carcinoma (HCC). MASH‐associated liver fibrosis develops through a complex interplay among lipotoxic hepatocyte injury, oxidative and endoplasmic reticulum stress, inflammatory ...
Ah‐Reum Oh +8 more
wiley +1 more source