Results 1 to 10 of about 27,316 (143)

Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases [PDF]

Cells
The phosphodiester linkage is found in DNA, RNA and many signaling molecules, such as cyclic mononucleotide, cyclic dinucleotides (CDNs) and cyclic oligonucleotides (cONs). Enzymes that cleave the phosphodiester linkage (nucleases and phosphodiesterases)
Christopher S. Vennard, Samson Marvellous Oladeji, Herman O. Sintim   +2 more
doaj   +2 more sources

Dynamic Executors of Bacterial Signals: Functional Versatility and Regulatory Networks of c-di-GMP Effectors [PDF]

Biomolecules
Cyclic di-GMP (c-di-GMP), a universal second messenger in bacteria, orchestrates a wide array of essential life processes. Its intracellular dynamics are meticulously regulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), ensuring ...
Jia Jia, Ge Yun, Bingxin Liu, Xinxin Li, Meiling Jiang, Xinlu Yu, Jing Zhang, Yufei Han, Dan Liu, Junlong Zhao, Yuanyuan Wang, Gukui Chen   +11 more
doaj   +2 more sources

cAMP Compartmentalisation in Human Myometrial Cells

Cells, 2023
Preterm birth is the leading cause of childhood mortality and morbidity. A better understanding of the processes that drive the onset of human labour is essential to reduce the adverse perinatal outcomes associated with dysfunctional labour.
Alice Varley, Andreas Koschinski, Mark R. Johnson, Manuela Zaccolo   +3 more
doaj   +1 more source

Identification and characterization of a novel phosphodiesterase from the metagenome of an Indian coalbed. [PDF]

PLoS ONE, 2015
Phosphoesterases are involved in the degradation of organophosphorus compounds. Although phosphomonoesterases and phosphotriesterases have been studied in detail, studies on phosphodiesterases are rather limited.
Durgesh Narain Singh, Ankush Gupta, Vijay Shankar Singh, Rajeev Mishra, Suneel Kateriya, Anil Kumar Tripathi   +5 more
doaj   +1 more source

Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies

Biology, 2023
Background: Cyclic nucleotides are second messengers, which play significant roles in numerous biological processes. Previous work has shown that cAMP and cGMP signaling regulates various pathways in liver cells, including Kupffer cells, hepatocytes ...
Diego Montoya-Durango, Mary Nancy Walter, Walter Rodriguez, Yali Wang, Julia H. Chariker, Eric C. Rouchka, Claudio Maldonado, Shirish Barve, Craig J. McClain, Leila Gobejishvili   +9 more
doaj   +1 more source

A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell patients

Frontiers in Physiology, 2023
Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the mechanical obstruction of the microcirculation by poorly deformable red blood ...
Evrim Goksel, Evrim Goksel, Evrim Goksel, Elif Ugurel, Elif Ugurel, Elie Nader, Elie Nader, Camille Boisson, Camille Boisson, Ingrid Muniansi, Ingrid Muniansi, Philippe Joly, Philippe Joly, Celine Renoux, Celine Renoux, Alexandra Gauthier, Philippe Connes, Philippe Connes, Ozlem Yalcin, Ozlem Yalcin   +19 more
doaj   +1 more source

Identification and Characterization of Four c-di-GMP-Metabolizing Enzymes from Streptomyces ghanaensis ATCC14672 Involved in the Regulation of Morphogenesis and Moenomycin A Biosynthesis

Microorganisms, 2021
Diguanylate cyclases (DGCs) and phosphodiesterases (PDEs) are essential enzymes deputed to maintain the intracellular homeostasis of the second messenger cyclic dimeric (3′→5′) GMP (c-di-GMP).
Desirèe Nuzzo, Roman Makitrynskyy, Olga Tsypik, Andreas Bechthold   +3 more
doaj   +1 more source

Potential PDE4B inhibitors as promising candidates against SARS‐CoV‐2 infection

Biomolecular Concepts, 2023
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an RNA virus belonging to the coronavirus family responsible for coronavirus disease 2019 (COVID-19).
Giuzio Federica, Bonomo Maria Grazia, Catalano Alessia, Infantino Vittoria, Salzano Giovanni, Monné Magnus, Geronikaki Athina, Petrou Anthi, Aquaro Stefano, Sinicropi Maria Stefania, Saturnino Carmela   +10 more
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3-[(1H-Benzo[d][1,2,3]triazol-1-yl)oxy]propyl 9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate

Molbank, 2022
We herein report on the synthesis of a pentacyclic triterpene functionalized through derivation of betulinic acid with hydroxybenzotriazole. The compound was fully characterized by proton (1H-NMR), carbon-13 (13C-NMR), heteronuclear single quantum ...
Ai Jiang, Margrate Anyanwu, Kafai Leong, Jinxin Li, Alessandra Gianoncelli, Paolo Coghi, Giovanni Ribaudo   +6 more
doaj   +1 more source

CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms

Cells, 2023
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isoforms.
Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O. Nikolaev   +6 more
doaj   +1 more source