Results 31 to 40 of about 27,465 (289)

Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo [PDF]

, 2013
Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of essential processes in diverse cell types, functioning via cAMP-dependent effectors such as protein kinase A (PKA) and/or exchange proteins directly activated by cAMP (EPAC ...
Akbari, Baillie, Beyenbach, Beyenbach, Bos, Bos, Bos, Brand, Börner, Cabrero, Chepurny, Coast, Coast, Coast, Coast, Dames, Davies, Day, de Rooij, Dow, Dow, Dow, Dow, Enserink, Evans, Gloerich, Guo, Hallows, Hector, Iijima–Ando, Johnson, Johnson, Kalderon, Kandel, Kaufmann, Kaupp, Kerr, Laroche–Joubert, MacPherson, O'Donnell, O'Donnell, Parks, Pastor–Soler, Pastor–Soler, Poulsen, Radford, Rein, Rosay, Ryu, Ryu, Schröder–Lang, Stierl, Stokman, Sözen, Terhzaz, Terhzaz, Torrie, Weissenberger, Wong, Zaccolo, Zaccolo   +60 more
core   +1 more source

Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data. [PDF]

, 2018
BackgroundAlthough studies involving preterm infants ≤34 weeks gestation report a decreased incidence of patent ductus arteriosus after antenatal betamethasone, studies involving younger gestation infants report conflicting results.MethodsWe used preterm
A El-Khuffash, AC Vidaeff, AM Ring, B Schmidt, B Thebaud, C Kahler, Christopher W. Hooper, Donald McCurnin, E Michelakis, E Pagni, EJ Plosa, EL Shelton, Elaine L. Shelton, Erin J. Plosa, F Coceani, F Schena, F Waffarn, Ginger L. Milne, H Liu, H Ozdemir, HW Park, J Reese, JD Stewart, Jeff Reese, JJ Coalson, John T. Benjamin, K Momma, K Toyoshima, LW Doyle, LW Gonzales, M Eronen, M Liebowitz, M Liebowitz, N Waleh, N Waleh, N Waleh, N Wasserstrum, Nahid Waleh, Naoko Brown, Noah J. Ehinger, OM Peltoniemi, PA Crowley, RD Roghair, RI Clyman, RI Clyman, Ronald I. Clyman, S Costa, Stanley Poole, Steven Seidner, W Onland, Y Ichikawa   +50 more
core   +2 more sources

Phosphodiesterases and cAMP Pathway in Pituitary Diseases

Frontiers in Endocrinology, 2019
Human phosphodiesterases (PDEs) comprise a complex superfamily of enzymes derived from 24 genes separated into 11 PDE gene families (PDEs 1–11), expressed in different tissues and cells, including heart and brain.
Mariana Ferreira Bizzi, Graeme B. Bolger, Graeme B. Bolger, Márta Korbonits, Antonio Ribeiro-Oliveira Jr.   +4 more
doaj   +1 more source

Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

Frontiers in Endocrinology, 2023
The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases.
Stepan Gambaryan, Sanika Mohagaonkar, Sanika Mohagaonkar, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +4 more
doaj   +1 more source

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling. [PDF]

, 2015
Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning.
Alessandra Ghigo, Angelo Maffei, Daniela Carnevale, Emilio Hirsch, Fabio Pallante, Franklin KBJ, Giuseppe Lembo, Ivana D'Andrea, Roberta Iacobucci, Stefania Fardella, Valentina Fardella   +10 more
core   +1 more source

Functional Analysis of Two Affinity cAMP Phosphodiesterases in the Nematode-Trapping Fungus Arthrobotrys oligospora

Pathogens, 2022
Phosphodiesterases are essential regulators of cyclic nucleotide signaling with diverse physiological functions. Two phosphodiesterases, PdeH and PdeL, have been identified from yeast and filamentous fungi.
Ni Ma, Ke-Xin Jiang, Na Bai, Dong-Ni Li, Ke-Qin Zhang, Jin-Kui Yang   +5 more
doaj   +1 more source

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
A Dawn, A Heiber, A Merckx, A Pantaleo, A Sudo, AE Bianco, Audrey Lorthiois, Bernina Naissant, C Lavazec, C Lavazec, C Syin, Catherine Lavazec, CJ Taylor, D Yokoyama, DA Baker, David A. Baker, DK Muhia, Dominique Soldati-Favre, Donatella Taramelli, E Farfour, E Lasonder, E Ling, Eloise Thompson, F Hawking, F Silvestrini, F Silvestrini, Florence Breil, Florian Dupuy, G Deplaine, Ghania Ramdani, Gordon Langsley, HM Taylor, I Koshino, J Bain, K Leykauf, Kenneth Vernick, KM Tang, L Chen, L McRobert, L Wentzinger, LK Read, M Aingaran, M Boolell, M Hliscs, M Tiburcio, M Tiburcio, ME Smalley, MJ Lopez-Barragan, MK Dearnley, MW Dixon, N Goto, N Mohandas, Odile Mercereau-Puijalon, QL Fivelman, R Aguilar, R Joice, RE Sinden, RE Sinden, RL Coppel, Ross Cummings, RW Moon, S D'Alessandro, S Kunz, S Sanyal, SM Knebel, SP Davies, SP Kim, T Bousema, T Harrison, T Ono, T Seebeck, W Trager, WB Smith 2nd, Yoann Duffier, Yolanda Corbett   +74 more
core   +9 more sources

Viral Nucleases

Viruses, 2023
Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA (DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand (endonucleases) or from the end (exonucleases) [...]
Zhengqiang Wang, Robert J. Geraghty
doaj   +1 more source

The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference! [PDF]

, 2015
Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the most serious human diseases, including Chagas disease (Trypanosoma ...
De Koning, Harry P., Kalejaiye, Titilola D., Tagoe, Daniel N. A.   +2 more
core   +1 more source

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source