Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis [PDF]
Molecular Metabolism, 2021 Background: Phosphoenolpyruvate carboxykinase (PCK) has been almost exclusively recognized as a critical enzyme in gluconeogenesis, especially in the liver and kidney.
Shuo Yu +3 more
doaj +3 more sources
The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo. [PDF]
Sci Adv, 2022 We here examined the potential biological function of phosphoenolpyruvate carboxykinase 1 (PCK1) in angiogenesis. shRNA- or CRISPR-Cas9–induced PCK1 depletion potently inhibited endothelial cell proliferation, migration, sprouting, and tube formation ...
Yao J +10 more
europepmc +2 more sources
Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families [PDF]
Orphanet Journal of Rare Diseases, 2023 Background In metabolic stress, the cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) enzyme is involved in energy production through the gluconeogenesis pathway.
Marwa Al Busaidi +8 more
doaj +2 more sources
Nature Communications, 2017 Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its ...
Xue-li Bian +14 more
doaj +2 more sources
Identification of phosphoenolpyruvate carboxykinase 1 as a potential therapeutic target for pancreatic cancer [PDF]
Cell Death and Disease, 2021 Pancreatic cancer is the third leading cause of cancer-related mortalities and is characterized by rapid disease progression. Identification of novel therapeutic targets for this devastating disease is important. Phosphoenolpyruvate carboxykinase 1 (PCK1)
Xiao-ren Zhu +6 more
doaj +2 more sources
Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine.
Am J Physiol Gastrointest Liver Physiol, 2018 Cytosolic phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme that is highly expressed in the liver and kidney but is also expressed at lower levels in a variety of other tissues where it may play adjunct roles in fatty acid ...
Potts A +9 more
europepmc +2 more sources
Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma [PDF]
Cell Death DiscoveryUveal melanoma (UVM), an uncommon yet potentially life-threatening ocular cancer, arises from melanocytes in the uveal tract of the eye. The exploration of novel oncotargets for UVM is of paramount importance.
Hui-e Bi +6 more
doaj +2 more sources
Discovery of PPi-type Phosphoenolpyruvate Carboxykinase Genes in Eukaryotes and Bacteria. [PDF]
J Biol Chem, 2015 Background: Inorganic pyrophosphate-type phosphoenolpyruvate carboxylase (PPi-PEPCK) was unidentified. Results: A conserved hypothetical protein was annotated as PPi-PEPCK.
Chiba Y +4 more
europepmc +2 more sources
Biallelic pathogenic variants in the mitochondrial form of phosphoenolpyruvate carboxykinase cause peripheral neuropathy [PDF]
HGG Advances, 2023 Summary: Phosphoenolpyruvate carboxykinase (PCK) plays a critical role in cytosolic gluconeogenesis, and defects in PCK1 cause a fasting-aggravated metabolic disease with hypoglycemia and lactic acidosis.
Neal Sondheimer +10 more
doaj +2 more sources
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism.
Cell Metab, 2023 Gonzalez-Rellan MJ +27 more
europepmc +2 more sources