Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families [PDF]
Orphanet Journal of Rare Diseases, 2023 Background In metabolic stress, the cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) enzyme is involved in energy production through the gluconeogenesis pathway.
Marwa Al Busaidi +8 more
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Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis [PDF]
Molecular Metabolism, 2021 Background: Phosphoenolpyruvate carboxykinase (PCK) has been almost exclusively recognized as a critical enzyme in gluconeogenesis, especially in the liver and kidney.
Shuo Yu +3 more
doaj +2 more sources
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Cell Metabolism, 2023 Summary Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally downregulated protein 8 (NEDD8). Here, we show that neddylation in mouse liver is modulated by nutrient availability.
Gonzalez-Rellan, María J. +27 more
openaire +5 more sources
Biallelic pathogenic variants in the mitochondrial form of phosphoenolpyruvate carboxykinase cause peripheral neuropathy [PDF]
HGG Advances, 2023 Summary: Phosphoenolpyruvate carboxykinase (PCK) plays a critical role in cytosolic gluconeogenesis, and defects in PCK1 cause a fasting-aggravated metabolic disease with hypoglycemia and lactic acidosis.
Neal Sondheimer +10 more
doaj +2 more sources
T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation [PDF]
Molecular Metabolism, 2022 Objectives: Thyroid hormone (T3) and high glucose concentrations are critical components of β-cell maturation and function. In the present study, we asked whether T3 and glucose signaling pathways coordinately regulate transcription of genes important ...
Liora S. Katz +3 more
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Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma [PDF]
Cell Death DiscoveryUveal melanoma (UVM), an uncommon yet potentially life-threatening ocular cancer, arises from melanocytes in the uveal tract of the eye. The exploration of novel oncotargets for UVM is of paramount importance.
Hui-e Bi +6 more
doaj +2 more sources
Identification of phosphoenolpyruvate carboxykinase 1 as a potential therapeutic target for pancreatic cancer [PDF]
Cell Death and Disease, 2021 Pancreatic cancer is the third leading cause of cancer-related mortalities and is characterized by rapid disease progression. Identification of novel therapeutic targets for this devastating disease is important. Phosphoenolpyruvate carboxykinase 1 (PCK1)
Xiao-ren Zhu +6 more
doaj +2 more sources
Phosphoenolpyruvate carboxykinases as emerging targets in cancer therapy
Frontiers in Cell and Developmental Biology, 2023 Metabolic reprogramming is commonly accompanied by alterations in the expression of metabolic enzymes. These metabolic enzymes not only catalyze the intracellular metabolic reaction, but also participate in a series of molecular events to regulate tumor ...
Yong Yu, Jingying Li, Kaiming Ren
doaj +3 more sources
Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males [PDF]
iScience, 2020 Summary: Dysregulated metabolism accelerates reduced decision-making and locomotor ability during aging. To identify mechanisms for delaying behavioral decline, we investigated how C.
Jimmy Goncalves +7 more
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The role of phosphoenolpyruvate carboxykinase in muscle alanine synthesis [PDF]
Biochemical Journal, 1984 3-Mercaptopicolinic acid (3-MPA) is reportedly a specific inhibitor of phosphoenolpyruvate (PEP) carboxykinase and has hitherto been used accordingly to elucidate the metabolic role of PEP carboxykinase in vitro and in vivo. We show that 3-MPA has multiple effects on intermediary metabolism in hemidiaphragms from 40 h-starved rats.
T. Norman Palmer +3 more
openalex +4 more sources