Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families [PDF]
Orphanet Journal of Rare Diseases, 2023 Background In metabolic stress, the cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) enzyme is involved in energy production through the gluconeogenesis pathway.
Marwa Al Busaidi +8 more
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Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis [PDF]
Molecular Metabolism, 2021 Background: Phosphoenolpyruvate carboxykinase (PCK) has been almost exclusively recognized as a critical enzyme in gluconeogenesis, especially in the liver and kidney.
Shuo Yu +3 more
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Nature Communications, 2017 Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its ...
Xue-li Bian, Hang-Zi Chen, Kun-Yi Chien
exaly +2 more sources
Identification of phosphoenolpyruvate carboxykinase 1 as a potential therapeutic target for pancreatic cancer [PDF]
Cell Death and Disease, 2021 Pancreatic cancer is the third leading cause of cancer-related mortalities and is characterized by rapid disease progression. Identification of novel therapeutic targets for this devastating disease is important. Phosphoenolpyruvate carboxykinase 1 (PCK1)
Xiao-ren Zhu +6 more
doaj +2 more sources
T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation [PDF]
Molecular Metabolism, 2022 Objectives: Thyroid hormone (T3) and high glucose concentrations are critical components of β-cell maturation and function. In the present study, we asked whether T3 and glucose signaling pathways coordinately regulate transcription of genes important ...
Liora S. Katz +3 more
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Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma [PDF]
Cell Death DiscoveryUveal melanoma (UVM), an uncommon yet potentially life-threatening ocular cancer, arises from melanocytes in the uveal tract of the eye. The exploration of novel oncotargets for UVM is of paramount importance.
Hui-e Bi +6 more
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Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males [PDF]
iScience, 2020 Summary: Dysregulated metabolism accelerates reduced decision-making and locomotor ability during aging. To identify mechanisms for delaying behavioral decline, we investigated how C.
Jimmy Goncalves +7 more
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Structural and functional studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2015 Tuberculosis, the second leading infectious disease killer after HIV, remains a top public health priority. The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb), which can cause both acute and clinically latent infections, reprograms ...
Iva Machová +9 more
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Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5 [PDF]
Biology Open, 2018 Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1.
Qingya Shen +4 more
doaj +2 more sources
Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma [PDF]
Scientific ReportsMitochondrial phosphoenolpyruvate carboxykinase (PCK2), a mitochondrial isoenzyme, supports the growth of cancer cells under glucose deficiency conditions in vitro.
Chenxuan Li +5 more
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