Results 101 to 110 of about 43,737 (252)

Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detected by RNA-seq

Genes and Diseases, 2020
Phosphoenolpyruvate carboxykinase 1 (PCK1), a step limiting enzyme of gluconeogenesis, is downregulated in hepatocellular carcinoma (HCC). Overexpression of PCK1 has been shown to suppress hepatoma cell growth, but the underlying mechanism remains ...
Jin Xiang, Yuhong Zhang, Lin Tuo, Rui Liu, Dongmei Gou, Li Liang, Chang Chen, Jie Xia, Ni Tang, Kai Wang   +9 more
doaj   +1 more source

The PEP—pyruvate—oxaloacetate node as the switch point for carbon flux distribution in bacteria: We dedicate this paper to Rudolf K. Thauer, Director of the Max-Planck-Institute for Terrestrial Microbiology in Marburg, Germany, on the occasion of his 65th birthday [PDF]

, 2017
In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node involves a structurally entangled set of reactions that interconnects the major pathways of carbon metabolism and thus, is responsible for the ...
Eikmanns, Bernhard J., Sauer, Uwe
core  

The relative importance of kinetic mechanisms and variable enzyme abundances for the regulation of hepatic glucose metabolism – insights from mathematical modeling [PDF]

, 2016
Background Adaptation of the cellular metabolism to varying external conditions is brought about by regulated changes in the activity of enzymes and transporters.
Berndt, Nikolaus, Bulik, Sascha, Holzhuetter, Hermann-Georg   +2 more
core   +1 more source

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R, Banerjee, R, Bell, J.D., Bell, J.D., Hemingway, H., Hemingway, H., Hingorani, A.D., Hingorani, A.D., Kelly, M., Kelly, M., McGonigle, J., McGonigle, J., Neubauer, S., Neubauer, S., Nicholls, R.C., Nicholls, R.C., Parisinos, C.A., Parisinos, C.A., Patel, R.S., Patel, R.S., Thomas, E.L., Thomas, E.L., Wilman, H., Wilman, H., Yaghootkar, H., Yaghootkar, H.   +25 more
core   +3 more sources

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, EarlyView.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source

Phosphoenolpyruvate Carboxykinase and Glucose-6-phosphatase Are Required for Steroidogenesis in Testicular Leydig Cells*

Journal of Biological Chemistry, 2012
Background: PEPCK is expressed in Leydig cells of testes, but its role has not been studied. Results: Knockdown and inhibition of PEPCK and Glc-6-Pase inhibited steroidogenesis via activation of AMPK.
S. Ahn, Gil-Tae Gang, S. Tadi, Balachandar Nedumaran, Y. D. Kim, Ji Hoon Park, G. Kweon, Seung-Hoi Koo, Keesook Lee, R. Ahn, Y. Yim, Chul‐Ho Lee, Robert A. Harris, Hueng-Sik Choi   +13 more
semanticscholar   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, EarlyView.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

The Role of Tyrosine 207 in the Reaction Catalyzed by Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase

Biological Research, 2010
The functional signifcance of tyrosine 207 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase was explored by examining the kinetic properties of the Tyr207Leu mutant. The variant enzyme retained the structural characteristics of the wild-type
Cherie Andrade, Carolina Sepulveda, Emilio Cardemil, Ana M Jabalquinto   +3 more
doaj  

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

Five nuclear protein-coding markers for establishing a robust phylogenetic framework of niphargid crustaceans (Niphargidae: Amphipoda) and new molecular sequence data

Data in Brief, 2019
The data presented here includes selection of 5 successfully amplified protein-coding markers for inferring phylogenetic relationships of the family of amphipod crustaceans Niphargidae. These markers have been efficiently amplified from niphargid samples
Ajda Moškrič, Rudi Verovnik
doaj   +1 more source