Results 101 to 110 of about 26,859 (247)

A Synthetic Facultative CAM‐Like Shuttle in C3 Rice Plants

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study utilizes gene editing and multigene stacking to design a facultative CAM‐like metabolic pathway that includes a stomatal regulation module, a carboxylation module, a decarboxylation module, and a malate transport module. A facultative CAM‐like metabolic pathway is created in C₃ rice, achieving compatibility between the C₃ cycle and the CAM ...
Suting Wu, Kaining Jin, Haoshu Li, Guoxin Chen, Liying Zhang, Jinwen Yang, Shanshan Zhai, Yanni Li, Xuehui Sun, Xuean Cui, Jing Sun, Tiegang Lu, Zhiguo Zhang   +12 more
wiley   +1 more source

The PEP—pyruvate—oxaloacetate node as the switch point for carbon flux distribution in bacteria: We dedicate this paper to Rudolf K. Thauer, Director of the Max-Planck-Institute for Terrestrial Microbiology in Marburg, Germany, on the occasion of his 65th birthday [PDF]

, 2017
In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node involves a structurally entangled set of reactions that interconnects the major pathways of carbon metabolism and thus, is responsible for the ...
Eikmanns, Bernhard J., Sauer, Uwe
core  

RNA‐seq analysis of mitochondria‐related genes regulated by AMPK in the human trophoblast cell line BeWo

Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 649-661, April 2025.
Using RNA‐seq and other bioinformatics analyses, three clusters of mitochondria related genes, including aldo‐keto reductase family 1 members B10 and B15 (AKR1B10, AKR1B15), alanyl‐tRNA synthetase 1 (AARS1), mitochondrial ribosomal protein S6 (MRPS6), mitochondrial calcium uniporter dominant negative subunit beta (MCUB) and dihydrolipoamide branched ...
Bin Wu, Albert Gao, Bin He, Yun Chen, Xiangfeng Kong, Fayuan Wen, Haijun Gao   +6 more
wiley   +1 more source

The Role of Tyrosine 207 in the Reaction Catalyzed by Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase

Biological Research, 2010
The functional signifcance of tyrosine 207 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase was explored by examining the kinetic properties of the Tyr207Leu mutant. The variant enzyme retained the structural characteristics of the wild-type
Cherie Andrade, Carolina Sepulveda, Emilio Cardemil, Ana M Jabalquinto   +3 more
doaj  

Community‐Level Metabolic Shifts Following Land Use Change in the Amazon Rainforest Identified by a Supervised Machine Leaning Approach

Environmental Microbiology Reports, Volume 17, Issue 2, April 2025.
A machine learning (ML)‐derived metagenomic analysis of soils collected from Amazon forests and long‐term established pastures showed different microbial community strategies towards carbohydrate metabolism and energy allocation. The ML approach allowed the development of metabolic maps that explained process‐level modifications to the C and N ...
Md Abdul Wadud Khan, Brendan J. M. Bohannan, Kyle M. Meyer, Ann M. Womack, Klaus Nüsslein, James P. Grover, Jorge L. Mazza Rodrigues   +6 more
wiley   +1 more source

Disentangling Organ‐Specific Roles of Farnesoid X Receptor in Bile Acid and Glucolipid Metabolism

Liver International, Volume 45, Issue 4, April 2025.
ABSTRACT Background and Aims The farnesoid X receptor (FXR) is an attractive pharmaceutical target for metabolic dysfunction‐associated steatotic liver disease (MASLD). However, its tissue‐specific roles in energy metabolism remain controversial, hindering the development of effective therapies. To address this, new approaches are required.
Tingting Li, Chenyang Fu, Zhongzheng Tang, Changkun Li, Duanyi Hua, Bei Liu, Zheying Tao, Jie Yang, Li Zhang, Tingting Cheng, Shujie Wang, Guang Ning, Yanyun Gu   +12 more
wiley   +1 more source

Knocking out the carboxyltransferase interactor 1 (CTI1) in Chlamydomonas boosted oil content by fivefold without affecting cell growth

Plant Biotechnology Journal, Volume 23, Issue 4, Page 1230-1242, April 2025.
Summary The first step in chloroplast de novo fatty acid synthesis is catalysed by acetyl‐CoA carboxylase (ACCase). As the rate‐limiting step for this pathway, ACCase is subject to both positive and negative regulation. In this study, we identify a Chlamydomonas homologue of the plant carboxyltransferase interactor 1 (CrCTI1) and show that this protein
Zhongze Li, Minjae Kim, Jose Roberto da Silva Nascimento, Bertrand Legeret, Gabriel Lemes Jorge, Marie Bertrand, Fred Beisson, Jay J. Thelen, Yonghua Li‐Beisson   +8 more
wiley   +1 more source

Regulation of plant glycolysis and the tricarboxylic acid cycle by posttranslational modifications

The Plant Journal, Volume 122, Issue 1, April 2025.
SUMMARY Plant glycolysis and the tricarboxylic acid (TCA) cycle are key pathways of central carbon metabolism. They facilitate energy transformation, provide redox balance, and supply the building blocks for biosynthetic processes that underpin plant survival, growth, and productivity.
Ke Zheng, Maria del Pilar Martinez, Maroua Bouzid, Manuel Balparda, Markus Schwarzländer, Veronica G. Maurino   +5 more
wiley   +1 more source

Abnormal lineage differentiation of peri‐implantation aneuploid embryos revealed by single‐cell RNA sequencing

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
Xueyao Chen, Hanwen Yu, Yu Yin, Bing Cai, Gaohui shi, Yan Xu, Lujuan Rong, Xiu Yu, Boyan Wang, Canquan Zhou, Jichang Wang, Chenhui Ding, Tianqing Li, Yanwen Xu   +13 more
wiley   +1 more source

Hypoglycemic mechanisms of Polygonatum sibiricum polysaccharide in db/db mice via regulation of glycolysis/gluconeogenesis pathway and alteration of gut microbiota

Heliyon, 2023
Polygonatum rhizoma polysaccharide (PP) is a main ingredient of Polygonatum rhizoma, which is both food and traditional herbal medicine. In this study, we aimed to investigate the hypoglycemic effect of PP and the underlying mechanisms in db/db mice. Our
Xuan Chen, Ye-ling Tong, Ze-ming Ren, Si-si Chen, Xi-yu Mei, Qing-yun Zhou, Guan-hai Dai   +6 more
doaj