Results 11 to 20 of about 43,737 (252)

Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma [PDF]

Cell Death Discovery
Uveal melanoma (UVM), an uncommon yet potentially life-threatening ocular cancer, arises from melanocytes in the uveal tract of the eye. The exploration of novel oncotargets for UVM is of paramount importance.
Hui-e Bi, Jie Zhang, Yujia Yao, Suyu Wang, Jin Yao, Zhijiang Shao, Qin Jiang   +6 more
doaj   +2 more sources

Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism.

Cell Metab, 2023
Gonzalez-Rellan MJ, Fernández U, Parracho T, Novoa E, Fondevila MF, da Silva Lima N, Ramos L, Rodríguez A, Serrano-Maciá M, Perez-Mejias G, Chantada-Vazquez P, Riobello C, Veyrat-Durebex C, Tovar S, Coppari R, Woodhoo A, Schwaninger M, Prevot V, Delgado TC, Lopez M, Diaz-Quintana A, Dieguez C, Guallar D, Frühbeck G, Diaz-Moreno I, Bravo SB, Martinez-Chantar ML, Nogueiras R.   +27 more
europepmc   +2 more sources

Discovery of PPi-type Phosphoenolpyruvate Carboxykinase Genes in Eukaryotes and Bacteria. [PDF]

J Biol Chem, 2015
Background: Inorganic pyrophosphate-type phosphoenolpyruvate carboxylase (PPi-PEPCK) was unidentified. Results: A conserved hypothetical protein was annotated as PPi-PEPCK.
Chiba Y, Kamikawa R, Nakada-Tsukui K, Saito-Nakano Y, Nozaki T.   +4 more
europepmc   +2 more sources

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. [PDF]

Molecules and Cells, 2015
Cancer cells adapt metabolically to proliferate under nutrient limitation. Here we used combined transcriptional-metabolomic network analysis to identify metabolic pathways that support glucose-independent tumor cell proliferation.
E. Vincent, A. Sergushichev, Takla Griss, M. Gingras, B. Samborska, Thierry Ntimbane, P. Coelho, J. Blagih, T. Raissi, L. Choinière, Gäelle Bridon, Ekaterina Loginicheva, B. Flynn, Elaine C. Thomas, J. Tavaré, D. Avizonis, A. Pause, D. Elder, M. Artyomov, Russell G. Jones   +19 more
semanticscholar   +4 more sources

Succinate Dehydrogenase-Regulated Phosphoenolpyruvate Carboxykinase Sustains Copulation Fitness in Aging C. elegans Males [PDF]

iScience, 2020
Summary: Dysregulated metabolism accelerates reduced decision-making and locomotor ability during aging. To identify mechanisms for delaying behavioral decline, we investigated how C.
Jimmy Goncalves, Yufeng Wan, Xiaoyan Guo, Kyoungsun Rha, Brigitte LeBoeuf, Liusuo Zhang, Kerolayne Estler, L. René Garcia   +7 more
doaj   +2 more sources

A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis [PDF]

Journal of Biological Chemistry, 2014
Background: PEPCK-M is generally considered irrelevant for glucose production, although gluconeogenesis has never been characterized in its absence.
Romana Stark, Fitsum Guebre‐Egziabher, Xiaojian Zhao, Colleen Feriod, Jianying Dong, Tiago C. Alves, Simona Ioja, Rebecca L. Pongratz, Sanjay Bhanot, Michael Roden, Gary W. Cline, Gerald I. Shulman, Richard G. Kibbey   +12 more
openalex   +2 more sources

Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) Is a Pro-survival, Endoplasmic Reticulum (ER) Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability

Journal of Biological Chemistry, 2014
Background: The integrated stress response (ISR) is necessary to help the tumor adapt to its microenvironment. Results: ATF4 activates a PEPCK-M-dependent pro-survival pathway under amino acid deprivation or ER stress (ISR) by binding to its proximal ...
Andrés Méndez-Lucas, Laura Novellasdemunt, Francesc Viñals   +2 more
exaly   +2 more sources

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth [PDF]

, 2016
We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombinant ...
David M. Brown, Hannah Williams, Kevin J. Ryan, Thomas L. Wilson, Z. Daniel, Molebeledi Mareko, Richard D. Emes, Douglas W. Harris, Sarah Jones, Jonathan A. D. Wattis, Ian L. Dryden, Charlie Hodgman, John M. Brameld, Tim Parr   +13 more
openalex   +6 more sources

Structural and functional studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2015
Tuberculosis, the second leading infectious disease killer after HIV, remains a top public health priority. The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb), which can cause both acute and clinically latent infections, reprograms ...
Iva Machová, Jan Snášel, Jiří Dostál, Jiří Brynda, Jindřich Fanfrlík, Mahavir Singh, Ján Tarábek, Ondřej Vaněk, Lucie Bednárová, Iva Pichová   +9 more
doaj   +2 more sources

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5 [PDF]

Biology Open, 2018
Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1.
Qingya Shen, Zhiyu Qiu, Wenping Wu, Jimin Zheng, Zongchao Jia   +4 more
doaj   +2 more sources