The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo [PDF]
Science Advances, 2022 Jin Yao
exaly +3 more sources
The Role of Tyrosine 207 in the Reaction Catalyzed by Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase [PDF]
Biological Research, 2010 The functional signifcance of tyrosine 207 of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase was explored by examining the kinetic properties of the Tyr207Leu mutant. The variant enzyme retained the structural characteristics of the wild-type
Cherie Andrade +3 more
doaj +2 more sources
O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α. [PDF]
PLoS ONE, 2017 PGC1α is a coactivator of many transcription factors and cytosolic phosphoenolpyruvate carboxykinase (PCK1) is a key enzyme for gluconeogenesis. PGC1α interacts with the transcription factor PPARγ to stimulate PCK1 expression and thus de novo glucose ...
Pedro Latorre +4 more
doaj +2 more sources
Phosphoenolpyruvate Carboxykinase Maintains Glycolysis-driven Growth in Drosophila Tumors. [PDF]
Sci Rep, 2017 Published online: 14 September 2017Tumors frequently fail to pass on all their chromosomes correctly during cell division, and this chromosomal instability (CIN) causes irregular aneuploidy and oxidative stress in cancer cells.
Hussain R +4 more
europepmc +5 more sources
The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells [PDF]
Scientific Reports, 2020 Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells. We
Madelaine C. Brearley +4 more
doaj +2 more sources
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth [PDF]
, 2016 We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombinant ...
A Bassols +58 more
core +5 more sources
A Novel PCK1 Gene Variant Associated With Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Two Siblings With Different Clinical Presentations [PDF]
JIMD ReportsCytosolic phosphoenolpyruvate carboxykinase (PEPCK‐C) deficiency is a rare autosomal recessive gluconeogenesis disorder caused by variants in the PCK1 gene.
Lauma Vasiļevska +6 more
doaj +2 more sources
Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer [PDF]
Cancer & Metabolism, 2019 Background Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutrient availability and requirements,
Emily D. Montal +8 more
doaj +2 more sources
Correction: O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α. [PDF]
PLoS ONE, 2017 [This corrects the article DOI: 10.1371/journal.pone.0179988.].
PLOS ONE Staff
doaj +2 more sources
Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity. [PDF]
J Biol Chem, 2021 Latorre-Muro P +10 more
europepmc +3 more sources