Results 31 to 40 of about 29,231 (198)

Biological Evaluation of a Mitochondrial Phosphoenolpyruvate Carboxykinase Inhibitor

Proceedings, 2019
Phosphoenolpyruvate carboxykinase (PEPCK) is a key enzyme in gluconeogenesis, catalyzingthe decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]
Sergio Rodríguez-Arévalo, Sònia Abás, Marc Aragó, Juan Moreno-Felici, Petra Hyroššová, Jose Carlos Perales, Carles Galdeano, Tiziana Ginex, Francisco Javier Luque, Carmen Escolano   +9 more
doaj   +1 more source

Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Nature Communications, 2023
Phosphoenolpyruvate carboxykinase 1 (Pck1) is an enzyme involved in glucose production that also regulates lipogenesis and has been linked to liver steatosis.
Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Xiaojun Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jiangao Fan, Qin Pan, Kai Wang, Ailong Huang, Ni Tang   +13 more
doaj   +1 more source

Dibenzylxanthines as PPEPCK-M Inhibitors for Cancer Therapy

Proceedings, 2019
Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in gluconeogenesis/glyceroneogenesis, which catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]
Marc Aragó, Sergio Rodríguez-Arévalo, Petra Hyrossova, Juan Moreno, Sònia Abás, Agnès Figueras, Belén Pérez, Francesc Viñals, María Carmen Escolano, José Carlos Perales   +9 more
doaj   +1 more source

Comparison of pepck gene expression in developing seeds and leaves of chickpea (Cicer arietinum L.) plant [PDF]

Journal of Cell and Molecular Research, 2009
Phosphoenolpyruvate Carboxykinase, encoded by the pepck gene, plays an important role in gluconeogenesis. It also seems to be important in metabolism of nitrogenous compounds in developing seeds of legumes, including amides and ureides which are then ...
Ahmad Reza Bahrami, Maria Beihaghi, Abdolreza Bagheri, Richard Leegood, Mehdi Ghabooli, Jafar Zolala, Farajollah Shahriari   +6 more
doaj   +1 more source

Cloning and expression of phosphoenolpyruvate carboxykinase from Escherichia coli

Journal of Hebei University of Science and Technology, 2019
In order to better study the structure and function of phosphoenolpyruvate carboxylase, the phosphoenolpyruvate carboxylase gene is cloned and expressed by PCR (polymerase chain reaction), double enzyme digestion and cell transformation. The results show
Xiaoliang HE, Zhu2 LI, Liqiang2 LIANG, Wanli MENG, Lantian MIAO, Yaozu SUN, Hongguang2 CAI   +6 more
doaj   +1 more source

Intestinal gluconeogenesis and glucose transport according to body fuel availability in rats [PDF]

J Physiol 566 (15/07/2005) 575-86, 2007
Intestinal hexose absorption and gluconeogenesis have been studied in relation to refeeding after two different fasting phases: a long period of protein sparing during which energy expenditure is derived from lipid oxidation (phase II), and a later phase characterized by a rise in plasma corticosterone triggering protein catabolism (phase III).
arxiv   +1 more source

Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions

Frontiers in Bioengineering and Biotechnology, 2021
Wild-type C. glutamicum ATCC 13032 is known to possess two enzymes with anaplerotic (C4-directed) carboxylation activity, namely phosphoenolpyruvate carboxylase (PEPCx) and pyruvate carboxylase (PCx). On the other hand, C3-directed decarboxylation can be
Jannick Kappelmann, Bianca Klein, Mathias Papenfuß, Julian Lange, Bastian Blombach, Ralf Takors, Wolfgang Wiechert, Tino Polen, Stephan Noack   +8 more
doaj   +1 more source

Extraction and Measurement the Activities of Cytosolic Phosphoenolpyruvate Carboxykinase (PEPCK) and Plastidic NADP-dependent Malic Enzyme (ME) on Tomato (Solanum lycopersicum)

Bio-Protocol, 2014
A recent study demonstrated that cytosolic phosphoenolpyruvate carboxykinase (PEPCK) and NADP-malic enzyme (NADP-ME) have an important role in malate metabolism during fruit ripening (Osorio et al., 2013). PEPCK catalyze the ATP-dependent decarboxylation
Sonia Osorio, José Vallarino, Marek Szecowka, Shai Ufaz, Vered Tzin, Ruthie Angelovici, Gad Galili, Fayezeh Aarabi   +7 more
doaj   +1 more source

Phosphoenolpyruvate carboxykinases as emerging targets in cancer therapy

Frontiers in Cell and Developmental Biology, 2023
Metabolic reprogramming is commonly accompanied by alterations in the expression of metabolic enzymes. These metabolic enzymes not only catalyze the intracellular metabolic reaction, but also participate in a series of molecular events to regulate tumor ...
Yong Yu, Jingying Li, Kaiming Ren
doaj   +1 more source

Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors.

Cancer Research, 2015
Although metabolic defects have been investigated extensively in differentiated tumor cells, much less attention has been directed to the metabolic properties of stem-like cells that repopulate tumors [tumor-repopulating cells (TRC)].
Yong Li, Shunqun Luo, R. Ma, Jing Liu, P. Xu, Huafeng Zhang, Ke Tang, Jingwei Ma, Yi Zhang, Xiaoyu Liang, Yanling Sun, T. Ji, Ning Wang, Bo Huang   +13 more
semanticscholar   +1 more source