Results 11 to 20 of about 5,315 (148)

Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation.

Journal of Biological Chemistry, 1988
It is now well established that cAMP induces the transcription rate of the gene for phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) and that this induction is dependent on a nucleotide domain located within the promoter-regulatory region of the gene (Short, J. M., Wynshaw-Boris, A., Short, H. P., and Hanson, R. W. (1986) J. Biol. Chem.
Y Hod, Richard W. Hanson
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Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. [PDF]

Proceedings of the National Academy of Sciences, 1983
The gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) [GTP:oxaloacetate carboxy-lyase (transphosphorylating), EC 4.1.1.32] from the rat was isolated from a recombinant library containing the rat genome in phage lambda Charon 4A. The isolated clone, lambda PCK1, contains the complete gene for phosphoenolpyruvate carboxykinase and approximately ...
David Samols, Heidi P. Short, Jay M. Short, Anthony Wynshaw-Boris, Herman Meisner, Alan Bruzel, Heeja Yoo-Warren, John Monahan, Richard W. Hanson   +8 more
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Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP).

Journal of Biological Chemistry, 1976
The hypoglycemic agent 3-mercaptopicolinic acid inhibits gluconeogenesis from lactate by isolated, perfused livers from fasted rats and guinea pigs. A 3-mercaptopicolinate concentration of 50 muM caused a sharp decrease in glucose synthesis, with virtually complete inhibition at 100 muM.
Mireille Jomain-Baum, Vern L. Schramm, Richard W. Hanson   +2 more
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In Vitro Analysis of Promoter Elements Regulating Transcription of the Phosphoenolpyruvate Carboxykinase (GTP) Gene [PDF]

Molecular and Cellular Biology, 1990
A cell-free system for the study of transcription from the promoter of the phosphoenolpyruvate carboxykinase (GTP) gene by using nuclear extracts from rat tissues was developed. The level of basal transcription from the phosphoenolpyruvate carboxykinase (PEPCK) promoter between -490 and +73 was highest when extracts from liver nuclei, rather than ...
Dwight J. Klemm, Jinsong Liu, William J. Roesler, Edwards A. Park, Richard W. Hanson   +4 more
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Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin [PDF]

Biochemical Journal, 1976
1. The regulation of the synthesis of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) in epididymal adipose tissue, liver and kidney in vivo was studied immunochemically. 2. Phosphoenolpyruvate carboxykinase (GTP) synthesis in adipose tissue is increased by starvation, diabetes and noradrenaline, and decreased by re-feeding and insulin.
O Meyuhas, Lea Reshef, J M Gunn, Richard W. Hanson, F J Ballard   +4 more
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SREBP-1c and Sp1 Interact to Regulate Transcription of the Gene for Phosphoenolpyruvate Carboxykinase (GTP) in the Liver [PDF]

Journal of Biological Chemistry, 2004
The sterol regulatory element-binding protein-1c (SREBP-1c), as well as SREBP-1a and SREBP-2, inhibit transcription of the gene encoding the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C). There are two SREBP regulatory elements (SREs) in the PEPCK-C gene promoter (-322 to -313 and -590 to -581).
Shwu Yuan Wu, Richard W. Hanson, Cheng Ming Chiang, David Samols, Kaushik Chakravarty   +4 more
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Overcoming Diabetes-Induced Hyperglycemia through Inhibition of Hepatic Phosphoenolpyruvate Carboxykinase (GTP) with RNAi [PDF]

Molecular Therapy, 2006
Phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32) is the rate-controlling enzyme in gluconeogenesis. In diabetic individuals, altered rates of gluconeogenesis are responsible for increased hepatic glucose output and sustained hyperglycemia. Liver-specific inhibition of PEPCK has not been assessed to date as a treatment for diabetes.
Ramon Bartrons, Jordi Bermúdez, Anna Vidal-Alabró, Alicia G. Gómez-Valadés, Jose C. Perales, Maria Molas, Jordi Boada   +6 more
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Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes

Journal of Biological Chemistry, 1993
The hormonal regulation of transcription of the phosphoenolpyruvate carboxykinase (GTP) (4.1.1.32) (PEPCK) gene during diabetes was studied using transgenic mice containing a chimeric gene consisting of segments of the PEPCK promoter (-2000/+73, -460/+73, -355/+73) linked to bovine growth hormone (bGH) reporter gene.
Richard W. Hanson, Yashomati M. Patel, Jacob E. Friedman, Mary M. McGrane, Jeung S. Yun   +4 more
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Identification of a DNA clone to phosphoenolpyruvate carboxykinase (GTP) from rat cytosol. Alterations in phosphoenolpyruvate carboxykinase RNA levels detectable by hybridization. [PDF]

Journal of Biological Chemistry, 1981
K Felz, Jonathan Leis, H Yoo-Warren, John Monahan, Michele A. Cimbala, Richard W. Hanson   +5 more
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Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse*♦ [PDF]

Journal of Biological Chemistry, 2007
Transgenic mice, containing a chimeric gene in which the cDNA for phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C) (EC 4.1.1.32) was linked to the α-skeletal actin gene promoter, express PEPCK-C in skeletal muscle (1-3 units/g).
Parvin Hakimi, Jianqi Yang, G. Casadesus, D. Massillon, Fatima Tolentino‐Silva, Colleen K. Nye, M. Cabrera, David R Hagen, Christopher B Utter, Yacoub Baghdy, David H. Johnson, D. Wilson, J. Kirwan, S. Kalhan, R. Hanson   +14 more
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