Results 31 to 40 of about 22,467 (165)
Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020
Expert Opinion on Therapeutic Patents, 2021 Introduction:The phosphoglycerate dehydrogenase (PHGDH), a metabolic enzyme involved in the serine synthetic pathway (SSP), appears to play a central role in supporting cancer growth and proliferation. PHGDH is a dehydrogenase whose expression in cancers was first demonstrated in 2010.
Quentin Spillier, Raphaël Frédérick
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mBio, 2022 The ubiquitous presence of toxic arsenate (AsV) in the environment has raised mechanisms of resistance in all living organisms. Generally, bacterial detoxification of AsV relies on its reduction to arsenite (AsIII) by ArsC, followed by the export of ...
Emilio Bueno +7 more
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Phosphoglycerate Dehydrogenase from Soybean Nodules [PDF]
Plant Physiology, 1983 Phosphoglycerate dehydrogenase (EC 1.1.1.95), an enzyme believed to be involved in the synthesis of serine, an intermediate in ureide biosynthesis, has been purified about 200-fold from nodules of soybean (Glycine max L. Merr. cv Amsoy 71). The reaction was reversible and exhibited a strong pH dependence with optima of 9.4 and 6.1 for the forward and ...
M J, Boland, K R, Schubert
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Neurotransmitters in 3-phosphoglycerate dehydrogenase deficiency
European Journal of Pediatrics, 2000 Item does not contain ...
Koning, T.J. +6 more
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3-PGDH Deficiency, Seizures, and Microcephaly
Pediatric Neurology Briefs, 1998 The beneficial effects of oral L-serine (up to 500 mg/kg/day) and glycine (200 mg/kg/day) in 2 siblings, aged 7 and 5 years, with 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency are reported from University Children’s Hospital, Utrecht, The ...
J Gordon Millichap
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Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells
环境与职业医学, 2022 BackgroundThe key enzymes of serine synthesis pathway (SSP) play an important role in tumor growth, proliferation, and invasion, but their roles in arsenic carcinogenesis are unclear.ObjectiveTo observe the effects of NaAsO2 treatment on the expressions ...
Fengmin LI +5 more
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Expanding the clinical spectrum of 3‐phosphoglycerate dehydrogenase deficiency [PDF]
Journal of Inherited Metabolic Disease, 2010 Abstract3‐Phosphoglycerate dehydrogenase (3‐PGDH) deficiency is considered to be a rare cause of congenital microcephaly, infantile onset of intractable seizures and severe psychomotor retardation. Here, we report for the first time a very mild form of genetically confirmed 3‐PGDH deficiency in two siblings with juvenile onset of absence seizures and ...
Tabatabaie, L. +6 more
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Probing Subunit Interactions in 3‐Phosphoglycerate Dehydrogenase
The FASEB Journal, 2012 3‐Phosphoglycerate Dehydrogenase is a homotetramer with three types of subunit interfaces; between adjacent regulatory domains, cofactor domains, and across the central cavity of the tetramer. A single tryptophan per subunit lies at the cofactor interface and crosses over between adjacent subunits.
Falk, Bradley, Bell, Ellis
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Nature Communications, 2019 Resistance to the tyrosine kinase inhibitor Sorafenib, which is the standard treatment for advanced hepatocellular carcinoma, is a major clinical challenge.
Lai Wei +11 more
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Frontiers in Plant Science, 2018 The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Sabine Wulfert, Stephan Krueger
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