Results 71 to 80 of about 23,936 (103)

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. [PDF]

Am J Respir Cell Mol Biol, 2018
Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM.   +14 more
europepmc   +1 more source

Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. [PDF]

Bioorg Med Chem Lett, 2019
Mullarky E, Xu J, Robin AD, Huggins DJ, Jennings A, Noguchi N, Olland A, Lakshminarasimhan D, Miller M, Tomita D, Michino M, Su T, Zhang G, Stamford AW, Meinke PT, Kargman S, Cantley LC.   +16 more
europepmc   +1 more source

Identification and Biochemical Characterization of the Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase in Marchantia polymorpha. [PDF]

Front Plant Sci, 2018
Akashi H, Okamura E, Nishihama R, Kohchi T, Hirai MY.   +4 more
europepmc   +1 more source

Enhanced vulnerability to oxidative stress and induction of inflammatory gene expression in 3-phosphoglycerate dehydrogenase-deficient fibroblasts. [PDF]

FEBS Open Bio, 2018
Hamano M, Haraguchi Y, Sayano T, Zyao C, Arimoto Y, Kawano Y, Moriyasu K, Udono M, Katakura Y, Ogawa T, Kato H, Furuya S.   +11 more
europepmc   +1 more source

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. [PDF]

Bioorg Med Chem, 2018
Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB.   +14 more
europepmc   +1 more source

Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer. [PDF]

Onco Targets Ther, 2016
Xian Y, Zhang S, Wang X, Qin J, Wang W, Wu H.   +5 more
europepmc   +1 more source

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase. [PDF]

Mol Cell Oncol, 2016
Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA.   +3 more
europepmc   +1 more source

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). [PDF]

J Med Chem, 2017
Ravez S, Corbet C, Spillier Q, Dutu A, Robin AD, Mullarky E, Cantley LC, Feron O, Frédérick R.   +8 more
europepmc   +1 more source

Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase. [PDF]

Theranostics, 2018
Dong JK, Lei HM, Liang Q, Tang YB, Zhou Y, Wang Y, Zhang S, Li WB, Tong Y, Zhuang G, Zhang L, Chen HZ, Zhu L, Shen Y.   +13 more
europepmc   +1 more source

Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). [PDF]

Oncotarget, 2017
Unterlass JE, Wood RJ, Baslé A, Tucker J, Cano C, Noble MME, Curtin NJ.   +6 more
europepmc   +1 more source