Results 91 to 100 of about 375,644 (216)

Molecular phenotyping of the pal1 and pal2 mutants of Arabidopsis thaliana reveals far-reaching consequences on phenylpropanoid, amino acid, and carbohydrate metabolism [PDF]

, 2004
The first enzyme of the phenylpropanoid pathway, Phe ammonia-lyase (PAL), is encoded by four genes in Arabidopsis thaliana. Whereas PAL function is well established in various plants, an insight into the functional significance of individual gene family ...
Boerjan, Wout, De Rycke, Riet, Goeminne, Geert, Hostyn, Vanessa, Joseleau, Jean-Paul, Kushnir, Sergei, Messens, Eric, Morreel, Kris, Ralph, John, Rohde, Antje, Van Beeumen, Jozef, Van Doorsselaere, Jan, Van Driessche, Gonzalez, Vuylsteke, Marnik   +13 more
core   +3 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization

Biomolecules, 2023
In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase.
Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini, Stefano Bruno   +11 more
doaj   +1 more source

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation [PDF]

, 2015
Background The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, dependence
Brignole, Edward J, Davidson, Shawn Michael, Drennan, Catherine L, Fiske, Brian Prescott, Kini, Mitali, Mattaini, Katherine Ruth, Vander Heiden, Matthew G.   +6 more
core   +1 more source

Contrasting catalytic and allosteric mechanisms for phosphoglycerate dehydrogenases [PDF]

Archives of Biochemistry and Biophysics, 2012
D-3-Phosphoglycerate dehydrogenases (PGDH) exist with at least three different structural motifs and the enzymes from different species display distinctly different mechanisms. In many species, particularly bacteria, the catalytic activity is regulated allosterically through binding of l-serine to a distinct structural domain, termed the ACT domain ...
openaire   +2 more sources

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria

BMC Evolutionary Biology, 2017
Background An important feature of eukaryotic evolution is metabolic compartmentalization, in which certain pathways are restricted to the cytosol or specific organelles. Glycolysis in eukaryotes is described as a cytosolic process.
Melania Abrahamian, Meenakshi Kagda, Audrey M. V. Ah-Fong, Howard S. Judelson   +3 more
doaj   +1 more source

Global analysis of mannitol 2-dehydrogenase in lactobacillus reuteri crl 1101 during mannitol production through enzymatic, genetic and proteomic approaches [PDF]

, 2017
Several plants, fungi, algae, and certain bacteria produce mannitol, a polyol derived from fructose. Mannitol has multiple industrial applications in the food, pharmaceutical, and medical industries, being mainly used as a non-metabolizable sweetener in ...
Bleckwedel, Juliana, Fadda, Silvina G., Hebert, Elvira Maria, Mozzi, Fernanda Beatriz, Ortiz, María Eugenia, Picariello, Gianluca, Raya, Raul Ricardo   +6 more
core   +3 more sources

Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis.

Journal of Medicinal Chemistry, 2019
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate limiting enzyme in the serine synthesis pathway (SSP) in humans. It converts glycolysis derived 3-phosphoglycerate to 3-phosphopyruvate in a NADH/NAD+-dependent oxidation reaction.
Harald Weinstabl, Matthias Treu, J. Rinnenthal, S. Zahn, P. Ettmayer, G. Bader, G. Dahmann, D. Kessler, K. Rumpel, N. Mischerikow, F. Savarese, Thomas Gerstberger, M. Mayer, A. Zoephel, R. Schnitzer, W. Sommergruber, P. Martinelli, Heribert Arnhof, Biljana Peric-Simov, Karina Hofbauer, Géraldine Garavel, Yvonne Scherbantin, Sophie Mitzner, T. Fett, G. Scholz, Jens Bruchhaus, Michelle Burkard, Roland Kousek, Tuncay Ciftci, Bernadette Sharps, Andreas Schrenk, Christoph Harrer, D. Haering, B. Wolkerstorfer, Xuechun Zhang, Xiaobing Lv, A. Du, Dongyang Li, Yali Li, Jens Quant, M. Pearson, D. McConnell   +41 more
semanticscholar   +1 more source

Technobiological Pathways for High‐CO₂ Capture Using Micro‐/Macroalgae: Genetic Engineering, Process Automation, and Value‐Added Bioproducts

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Greenhouse gas (GHG) emissions have emerged as one of the most critical drivers of climate change; this is primarily due to high concentrations and long atmospheric life of carbon dioxide (CO2). For a significant amount of time, various biological processes such as microalgal cultivation, cyanobacterial systems, photosynthetic microorganisms ...
Sadhana Semwal, Harish Chandra Joshi
wiley   +1 more source