Results 91 to 100 of about 170,695 (197)

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

Oncotarget, 2013
Cancer cells rely on aerobic glycolysis to maintain cell growth and proliferation via the Warburg effect. Phosphoglycerate dehydrogenase (PHDGH) catalyzes the first step of the serine biosynthetic pathway downstream of glycolysis, which is a metabolic gatekeeper both for macromolecular biosynthesis and serine-dependent DNA synthesis.
Jinyun, Chen, Franklin, Chung, Guizhi, Yang, Minying, Pu, Hui, Gao, Wei, Jiang, Hong, Yin, Vladimir, Capka, Shailaja, Kasibhatla, Bryan, Laffitte, Savina, Jaeger, Raymond, Pagliarini, Yaoyu, Chen, Wenlai, Zhou   +13 more
openaire   +3 more sources

Microarray data on altered transcriptional program of Phgdh-deficient mouse embryonic fibroblasts caused by ʟ-serine depletion

Data in Brief, 2016
Inherent ʟ-Ser deficiency culminates in intrauterine growth retardation, severe malformation of multiple organs particularly the central nervous system, and perinatal or early postnatal death in human and mouse.
Momoko Hamano, Tomoko Sayano, Wataru Kusada, Hisanori Kato, Shigeki Furuya   +4 more
doaj   +1 more source

Extending the Farquhar–von Caemmerer–Berry photosynthesis model to account for various photorespiratory bypasses

New Phytologist, EarlyView.
We extend a widely used C3‐photosynthesis model to account for various photorespiratory bypasses, thereby, providing a useful resource and framework that enforces future novel bypass work and scrutinize if the results go counter to theory. Our model analyses show that of the 17 published bypass pathways, full‐decarboxylating bypasses (that have been ...
Xinyou Yin, Kaining Jin, Guoxin Chen, Tiegang Lu   +3 more
wiley   +1 more source

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth [PDF]

, 2012
SummaryIt is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated in human cancers due to loss of TP53, contributes ...
LeRoy, Gary, Chen, Georgia Z, Shin, Dong M, Kang, Sumin, Khuri, Fadlo R, Lee, Benjamin H, DeBerardinis, Ralph J., Hitosugi, Taro, Gu, Ting-Lei, Kang, Yibin, Sudderth, Jessica A, Lee, Benjamin H., Shin, Dong M., Khoury, Hanna J, Kang, Hee-Bum, Muller, Susan, Owonikoko, Taofeek K., DeBerardinis, Ralph J, Seo, Jae Ho, Fan, Jun, Zhang, Liang, Chen, Georgia Z., Lonial, Sagar, Khuri, Fadlo R., Elf, Shannon, He, Chuan, Arellano, Martha L., Xie, Jianxin, Alečković, Masa, Luan, Chi-Hao, Zhou, Lu, Shan, Changliang, Owonikoko, Taofeek K, Ye, Keqiang, Boggon, Titus J., Khoury, Hanna J., Boggon, Titus J, Arellano, Martha L, Dai, Qing, Sudderth, Jessica A., Jin, Peng, Chen, Jing   +41 more
core   +1 more source

Down regulating PHGDH affects the lactate production of sertoli cells in varicocele

Reproductive Biology and Endocrinology, 2020
Background Although varicocele is considered to be one of the leading causes of male infertility, the precise mechanism underlying how varicocele leads to male infertility is not completely understood. We found the lactate concentration on the varicocele
Wen-bin Guo, Zhen-hui Huang, Cheng Yang, Xian-yuan Lv, Hui Xia, Hu Tian, Jian-kun Yang, Qi-zhao Zhou, Ming-kun Chen, Kang-yi Xue, Cun-dong Liu   +10 more
doaj   +1 more source

Gene Editing of Nicotiana benthamiana Architecture for Space‐Efficient Production of Recombinant Proteins in Closed Environments

Plant Biotechnology Journal, EarlyView.
ABSTRACT Indoor vertical farming (VF) offers practical advantages for the cultivation of plant protein bio‐factories including plant uniformity, product consistency, water/nutrient recycling and production cycles on a year‐round basis. Much progress has been achieved toward the development of innovative systems for artificial lighting, automated ...
Béatrice Giroux, Kristina LeBreux, Louis Feyzeau, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +5 more
wiley   +1 more source

Spatiotemporal Dynamics of Cytosolic NADPH in Living Arabidopsis thaliana

Plant, Cell &Environment, EarlyView.
ABSTRACT In plants, an adequate supply of Nicotinamide adenine dinucleotide phosphate (NADPH) in the cytosol is crucial for maintaining a variety of biosynthetic and antioxidant reactions. Cytosolic NADPH is mainly generated via four enzymatic pathways: NADP‐dependent malic dehydrogenase (NADP‐ME), cytosolic oxidative pentose phosphate pathway (cOPPP),
Danying Lu, Jinhong Liu, Shey‐Li Lim, Jia Yi Zhong, Boon Leong Lim   +4 more
wiley   +1 more source

Coupling between d -3-phosphoglycerate dehydrogenase and d -2-hydroxyglutarate dehydrogenase drives bacterial l -serine synthesis

, 2017
Significance d -3-Phosphoglycerate dehydrogenase (SerA) is a key enzyme in l -serine biosynthesis.
Chao Gao, Zikang Zhou, Wen Zhang, Cuiqing Ma, Fei Tao, Xiaoting Guo, Manman Zhang, Yongsheng Ge, Qiuyuan Liu, Shiting Guo, Ping Xu, Yingxin Zhang, Yipeng Zhang   +12 more
core   +1 more source

Multi‐Subunit Engineering of Photorespiratory Glycine Decarboxylase Refines Photosynthesis, Growth and Metabolic Robustness of Arabidopsis

Plant, Cell &Environment, EarlyView.
ABSTRACT Photorespiration secures oxygenic photosynthesis from metabolic constraints arising from the oxygenation reaction of Rubisco in today's oxygen‐rich atmosphere. Beyond this protective function, it is vital for primary metabolism, cellular redox balance, and stomatal regulation.
Hu Sun, Yannic C. R. Wagner, Wieke‐Marie Rosenfeldt, Rhena Schumann, Stéphanie Arrivault, Guillaume Decros, Rhiannon Page, Elizabete Carmo Silva, Tracy Lawson, Wei Huang, Alisdair R. Fernie, Hermann Bauwe, Martin Hagemann, Stefan Timm   +13 more
wiley   +1 more source