Results 81 to 90 of about 23,057 (164)
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2075-2084, July 2026.Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source
Nicotinamide Reverses the Warburg Effect in CHO Cell Culture
Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1902-1915, July 2026.ABSTRACT The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey +7 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.NDRG1 suppresses pancreatic cancer progression by disrupting small extracellular vesicle biogenesis, altering cargo composition, and inhibiting EV uptake by cancer cells—thereby impairing tumour–stroma communication and fibrotic activation. This study reveals NDRG1 as a novel regulator of extracellular vesicle dynamics and a promising therapeutic ...
Jiawei Chang +8 more
wiley +1 more source
FEBS Open BioAllostery is an important property of biological macromolecules which regulates diverse biological functions such as catalysis, signal transduction, transport, and molecular recognition.
Veronica Morea +2 more
doaj +1 more source
Inhibitory Effect and Mechanism of Lotus Seedpod Polysaccharides on Cervical Cancer HeLa Cells [PDF]
Shipin KexueThis study aimed to investigate the inhibitory effect and mechanism of lotus seedpod polysaccharides (LSP) on cervical cancer HeLa cells using commercial kits, flow cytometry, cell scratch wound healing assay, and Transwell cell migration and invasion ...
HUANG Jing, ZENG Wei, CHEN Jianping, WANG Xiaoyin
doaj +1 more source
Molecular Carcinogenesis, Volume 65, Issue 7, Page 874-887, July 2026.ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha +26 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 7, Page 3543-3559, July 2026.ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador +5 more
wiley +1 more source
Targeting the Serine Pathway: A Promising Approach against Tuberculosis?
Pharmaceuticals, 2019 Tuberculosis is still the leading cause of death by a single infectious agent. Effective chemotherapy has been used and improved since the 1950s, but strains resistant to this therapy and most antibacterial drugs on the market are emerging.
Marie Haufroid, Johan Wouters
doaj +1 more source
eLife, 2019 The human macula is more susceptible than the peripheral retina to developing blinding conditions such as age-related macular degeneration, diabetic retinopathy. A key difference between them may be the nature of their Müller cells.
Ting Zhang +9 more
doaj +1 more source
AntibioticsPreviously, we reported that metronidazole MICs are not dependent on the expression levels of nim genes in B. fragilis strains and we compared the proteomes of metronidazole-resistant laboratory B.
Bakhtiyar Mahmood +6 more
doaj +1 more source