Results 81 to 90 of about 182,707 (224)

Altered expression of genes involved in the serine synthesis pathway (SSP) in patients with acute myeloid leukemia [PDF]

Journal of Kerman University of Medical Sciences
Background: Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of malignant cells, which rely on various metabolic pathways to sustain their survival and growth.
Parinaz Khadem, Ali Keshavarz, Mohammad Hossein Mohammadi, Fateme Mezginejad, Mehdi Allahbakhshian Farsani   +4 more
doaj   +1 more source

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization

Biomolecules, 2023
In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase.
Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini, Stefano Bruno   +11 more
doaj   +1 more source

Integrierte elektromikrobielle Produktion von Itaconsäure aus CO2 im Litermaßstab unter Verwendung von Komagataella phaffii

Angewandte Chemie, EarlyView.
Die Studie stellt ein neuartiges Hybridsystem vor, das die elektrochemische CO2‐Reduktion mit mikrobieller Biosynthese in einem Reaktor verbindet. Mithilfe einer synthetisch autotrophen Hefe wird CO2 zur Herstellung von Itaconsäure genutzt. Unter Nutzung einer Industriehefe zeigen wir das Potenzial dieses Ansatzes für die direkte Umwandlung von CO2 in ...
Paniz Izadi, Manja M. Severinsen Zijlstra, Aykut Kas, Philip Haus, Verena Enzinger, Gregor Lutz, Özge Ata, Simone Bachleitner, Diethard Mattanovich, Falk Harnisch   +9 more
wiley   +1 more source

Integrated Electromicrobial Production of Itaconic Acid From CO2 at Liter‐Scale Using Komagataella phaffii

Angewandte Chemie International Edition, EarlyView.
This study demonstrates a novel hybrid system that integrates electrochemical CO2 reduction with microbial biosynthesis in a single reactor, using a synthetic autotrophic yeast to produce itaconic acid from CO2. Using an industrial yeast provides feasibility of direct electromicrobial CO2 conversion to bio‐based building blocks while identifying key ...
Paniz Izadi, Manja M. Severinsen Zijlstra, Aykut Kas, Philip Haus, Verena Enzinger, Gregor Lutz, Özge Ata, Simone Bachleitner, Diethard Mattanovich, Falk Harnisch   +9 more
wiley   +1 more source

Impact of Agitation Power Input on Aspergillus oryzae Metabolism: Application of Multi‐Omics on an Industrial Enzyme Fermentation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino, Jean‐Marie Mouillon, Gisela Nadal‐Rey, Carina L. Gargalo, Ulrich Krühne, Krist V. Gernaey, Mads O. Albæk   +6 more
wiley   +1 more source

Intracellular trapping of the selective phosphoglycerate dehydrogenase (PHGDH) inhibitor BI-4924 disrupts serine biosynthesis

, 2019
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in the serine synthesis pathway in humans. It converts glycolysis-derived 3-phosphoglycerate to 3-phosphopyruvate in a co-factor-dependent oxidation reaction.
Mitzner, Sophie (author), Kousek, Roland (author), Bruchhaus, Jens (author), Rumpel, Klaus (author), Mischerikow, Nikolai (author), Ciftci, Tuncay (author), Treu, Matthias (author), Zahn, Stephan K. (author), Scholz, Guido (author), Martinelli, Paola (author), Fett, Thomas N. (author), Quant, Jens (author), Bader, Gerd (author), Scherbantin, Yvonne (author), Arnhof, Heribert (author), Peric-Simov, Biljana (author), Li, Yali (author), Hofbauer, Karin S. (author), Weinstabl, Harald (author), McConnell, Darryl B. (author), Burkard, Michelle (author), Kessler, Dirk (author), Ettmayer, Peter (author), Mayer, Moriz (author), Schnitzer, Renate (author), Schrenk, Andreas (author), Wolkerstorfer, Bernhard (author), Rinnenthal, Joerg (author), Garavel, Géraldine (author), Lv, Xiaobing (author), Sommergruber, Wolfgang (author), Haering, Daniela (author), Dahmann, Georg (author), Pearson, Mark (author), Harrer, Christoph (author), Li, Dongyang (author), Zoephel, Andreas (author), Sharps, Bernadette (author), Savarese, Fabio (author), Zhang, Xuechun (author), Gerstberger, Thomas (author), Du, Alicia (author)   +41 more
core   +1 more source

Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism [PDF]

, 2012
Kinetic models of metabolism require detailed knowledge of kinetic parameters. However, due to measurement errors or lack of data this knowledge is often uncertain.
Kerkhoven Eduard J., Barrett, M.P., Breitling, Rainer, Breitling, R., Fiona Achcar, Bakker, Barbara M.; id_orcid, Achcar, Fiona, Achcar, F., Eduard J. Kerkhoven (187101), Fiona Achcar (187100), Breitling Rainer, Bakker Barbara M., SilicoTryp Consortium, Barrett, Michael P., Rainer Breitling (4371), Michael P Barrett, Bakker, B.M., Barbara M. Bakker (102159), Bakker, Barbara M., Barbara M Bakker, Kerkhoven, Eduard J, Matthews, Keith; id_orcid, Bakker, Barbara M, Rainer Breitling, Barrett, Michael P, Kerkhoven, E.J., ?, ?, Eduard J Kerkhoven, Achcar Fiona, Barrett Michael P., Kerkhoven, Eduard J., Michael P. Barrett (167748), Breitling, Rainer; id_orcid   +32 more
core   +1 more source

Species Dynamics and Gene Expression in Algal Polycultures Under Mixotrophic Cultivation in Outdoor Pilot‐Scale Nordic Conditions

Biotechnology and Bioengineering, EarlyView.
These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham, Hanna Farnelid, Catherine Legrand, Elin Lindehoff   +3 more
wiley   +1 more source

Functional Characterization of the Plastidial 3-Phosphoglycerate Dehydrogenase Family in Arabidopsis [PDF]

Plant Physiology, 2013
This work contributes to unraveling the role of the phosphorylated pathway of serine (Ser) biosynthesis in Arabidopsis (Arabidopsis thaliana) by functionally characterizing genes coding for the first enzyme of this pathway, 3-phosphoglycerate dehydrogenase (PGDH).
Walid Toujani, Jesús Muñoz-Bertomeu, María Flores-Tornero, Sara Rosa-Téllez, Armand Djoro Anoman, Saleh Alseekh, Alisdair R. Fernie, Roc Ros   +7 more
openaire   +4 more sources

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source