Results 221 to 230 of about 193,906 (268)

Phenotypic and functional characteristics of pituitary adenoma stem cells. [PDF]

World J Clin Cases
Agosti E, Gelmini L, Panciani PP, Fiorindi A, Fontanella MM, Tengattini F, Denaro L, Gagliano C, Tognetto D, Zeppieri M.   +9 more
europepmc   +1 more source

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Emerging role of histone and non-histone lactylation in metabolic reprogramming of female-specific malignancies. [PDF]

World J Surg Oncol
Sun C, Hu D, Peng W, Cui Z, Lin Y.
europepmc   +1 more source

Harmine Derivatives as Anticancer Agents Endowed With Potent and Selective Antileukemia Activity: Synthesis, Biological Evaluation, Proapoptotic and Genotoxic Activity

Archiv der Pharmazie, Volume 359, Issue 2, February 2026.
We identified a novel N9‐substituted harmine analog, compound 6, that selectively suppresses leukemic cell growth, triggers DNA damage, and activates apoptosis while sparing healthy fibroblasts. This discovery highlights N9‐modified β‐carbolines as a powerful new class of selective antileukemic agents, bridging natural product chemistry with next ...
Abdul Aziz Timbilla, Filip Pidany, Eliska Kohelova, Jana Kroustkova, Karel Kralovec, Jan Rataj, Martina Ceckova, Negar Maafi, Víctor Lopez, Cristina Moliner Langa, Stefan Kosturko, Jaroslav Jenco, Darina Muthna, Darja Koutova, Martina Rezacova, Lucie Cahlikova, Jakub Chlebek, Radim Havelek   +17 more
wiley   +1 more source

Corticosteroid insensitivity in obese asthma: potential mechanisms and therapeutic perspectives. [PDF]

Front Allergy
To M, To Y.
europepmc   +1 more source

Statins in Breast Cancer Therapy: Mechanistic Insights and Emerging Evidence

Cancer Innovation, Volume 5, Issue 1, February 2026.
Statins, particularly simvastatin, demonstrate potential as adjuvant agents in breast cancer treatment by disrupting tumour cell signalling and survival pathways. This review highlights emerging evidence supporting their repurposing for improved outcomes, especially in aggressive breast cancer subtypes.
Rohina Alim, H. M. Kasuni Akalanka
wiley   +1 more source

<i>RGS4</i> in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression. [PDF]

World J Gastroenterol
Yang Y, Chen WM.
europepmc   +1 more source

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan, Cheng Zeng, Jiani Wang, Fei Ma   +3 more
wiley   +1 more source

Treatment strategies targeting the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin pathway against triple-negative breast cancer. [PDF]

World J Clin Oncol
Ni CX, Xu JJ, Pang Y, Xu JJ.
europepmc   +1 more source

Efficacy of Topical Beta‐Blockers in Managing Epidermal Growth Factor Receptor Inhibitor‐Related Paronychia and Pyogenic Granuloma‐Like Lesion: A Systematic Review and Meta‐Analysis

Cancer Medicine, Volume 15, Issue 2, February 2026.
The meta‐analysis, involving with 96 patients, shows high overall response rate with favorable safety to use topical beta‐blockers for epidermal growth factor receptor inhibitors‐induced periungual side effects. Subgroups of lung cancer or solution formation had lower complete response rate, while tyrosine kinase inhibitor and female patients had ...
Po‐Kai Chan, Wei‐Ting Yen, Po‐Huang Chen   +2 more
wiley   +1 more source