Results 171 to 180 of about 18,679,675 (294)

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, EarlyView.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

Targeting Phosphoinositide 3-Kinase to Reduce the Progression of Ovarian Cancer Cells in a 3D Collagen Model. [PDF]

Biomolecules
Tino AB, Sykes PH, Dachs GU, Chitcholtan K.   +3 more
europepmc   +1 more source

The association between inborn errors of immunity and Hodgkin lymphoma—A register‐based case–control study in Sweden

British Journal of Haematology, EarlyView.
Summary Immune dysfunction is implicated in the aetiology of Hodgkin lymphoma (HL), but the association between inborn errors of immunity (IEI) and HL remains poorly understood. We conducted a retrospective, register‐based case–control study in Sweden over five decades to investigate the relationship between IEI and HL. Individuals diagnosed with HL in
Agnes Winsa, Ingemar Lagerlöf, Fredrik Ellin, Mats Fredriksson, Åsa Nilsdotter‐Augustinsson, Marcus Bendtsen, Jörg Cammenga, Sofia Nyström   +7 more
wiley   +1 more source

A review of PI3K/AKT/mTOR inhibitors from traditional Chinese medicine: potential and perspective for activated phosphoinositide 3-kinase δ syndrome. [PDF]

Orphanet J Rare Dis
Xie Y, Nie L, Bai L, Zhao X.
europepmc   +1 more source

Evaluating the impact of leniolisib treatment on symptoms and health-related quality of life in activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome. [PDF]

Front Immunol
Rao VK, Morgan A, Torgerson TR, Harrington A, Whalen J, Munro E, Luscombe J, de la Motte A, Romero B, Bahar R, Bradt J.   +10 more
europepmc   +1 more source

Clinical and immunological spectrum of five patients with activated phosphoinositide 3-kinase δ syndrome 1: A multicentric study from India. [PDF]

J Hum Immun
Bhattad S, Singh N, Mohite RS, Janardhanan J, J T S, Shukla A, Jakka S, Joseph RB.   +7 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Antcin K suppresses osteoclastogenesis through modulation of the focal adhesion kinase and phosphoinositide 3-kinase pathways and attenuates ligature-induced periodontitis. [PDF]

J Dent Sci
Wu YH, Kuo YH, Lin YY, Chang TC, Ghule SS, Tang CH.   +5 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant. [PDF]

J Biol Chem
Papafotika A, Pavlaki M, Lazani V, Karamani VE, Aggelidis D, Kapella A, Kotzampasi DM, Agianian B, Efstratiadis A, Cournia Z, Christoforidis S.   +10 more
europepmc   +1 more source