Cancer Science, EarlyView.Using a machine learning–based approach in a multi‐institutional prospective cohort, we identified a robust miRNA signature that demonstrated high diagnostic accuracy for esophageal squamous cell carcinoma. Our 57‐miRNA panel achieved an AUC of 0.90 in the proof‐of‐concept cohort and 0.85 in an independent validation cohort, with a sensitivity of 84 ...
Tatsuro Murano +14 more
wiley +1 more source
Cancer Science, EarlyView.Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji +2 more
wiley +1 more source
[Retracted] Long non-coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3-kinase/protein kinase B signaling pathway. [PDF]
Exp Ther MedYan B, Wubuli A, Liu Y, Wang X.
europepmc +1 more source
p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway
Cell Proliferation, EarlyView.The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao +8 more
wiley +1 more source
Bimetallic Copper-Manganese Zeolitic Imidazolate Framework Nanozyme Scavenges Reactive Oxygen Species to Alleviate Osteoarthritis via Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Axis and Autophagic Flux Restoration. [PDF]
Biomater ResZheng X +9 more
europepmc +1 more source
Signaling by the phosphoinositide 3-kinase family in immune cells.
Annual Review of Immunology, 2013 K. Okkenhaug
semanticscholar +1 more source
Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death
The FEBS Journal, EarlyView.Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa +4 more
wiley +1 more source
Refractory marginal zone lymphoma uncovers activated phosphoinositide 3-kinase delta syndrome type 1 (APDS1). [PDF]
J Allergy Clin Immunol GlobWonnaparhown A +7 more
europepmc +1 more source
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
Targeting the Phosphoinositide 3-Kinase/Protein Kinase B Pathway Suppresses Y-Box Binding Protein 1 Expression and Inhibits Colorectal Cancer Progression. [PDF]
World J OncolShan H +7 more
europepmc +1 more source