Results 291 to 300 of about 425,150 (316)
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Advances in Biological Regulation, 2019
The Class I phosphoinositide 3-kinases (PI3Ks) are a group of heterodimeric lipid kinases that regulate crucial cellular processes including proliferation, survival, growth, and metabolism.
M. Rathinaswamy, J. Burke
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The Class I phosphoinositide 3-kinases (PI3Ks) are a group of heterodimeric lipid kinases that regulate crucial cellular processes including proliferation, survival, growth, and metabolism.
M. Rathinaswamy, J. Burke
semanticscholar +1 more source
Class I phosphoinositide 3-kinases
The International Journal of Biochemistry & Cell Biology, 2003Phosphoinositide 3-kinases (PI3-kinases) are a family of enzymes that 3'-phosphorylate the inositol head group of membrane phosphoinositides. They are subdivided into three major classes (I, II and III) based on their structural homology, regulation and substrate specificity. It is now becoming clear that PI3-kinase isoforms are subject to differential
Karen E, Anderson, Shaun P, Jackson
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Journal of Surgical Research, 2015
We previously demonstrated that inhibiting phosphoinositide 3-kinase (PI3K) or activating L-type calcium channels blocked the anti-inflammatory effects of magnesium sulfate (MgSO₄). However, the question as which class I PI3K isoform (PI3Kα, PI3Kβ, PI3Kδ, or PI3Kγ) is involved in this regard remains unstudied.
Ping-Ying, Lee +5 more
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We previously demonstrated that inhibiting phosphoinositide 3-kinase (PI3K) or activating L-type calcium channels blocked the anti-inflammatory effects of magnesium sulfate (MgSO₄). However, the question as which class I PI3K isoform (PI3Kα, PI3Kβ, PI3Kδ, or PI3Kγ) is involved in this regard remains unstudied.
Ping-Ying, Lee +5 more
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1999
Abstract Phosphoinositide 3OH-kinases (PI3Ks) are enzymes which can phosphorylate one or more membrane inositol lipids in the 3-position of the inositol ring; in vitro they can make phosphoinositide(3)phosphate (PtdIns(3)P), phospho- inositide(3,4)bisphosphate (PtdIns(3,4)P2), and phosphoinositide(3,4,5)triphos- phate (PtdIns(3,4,5)P3)
K E Anderson, L R Stephens,, P T Hawkins
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Abstract Phosphoinositide 3OH-kinases (PI3Ks) are enzymes which can phosphorylate one or more membrane inositol lipids in the 3-position of the inositol ring; in vitro they can make phosphoinositide(3)phosphate (PtdIns(3)P), phospho- inositide(3,4)bisphosphate (PtdIns(3,4)P2), and phosphoinositide(3,4,5)triphos- phate (PtdIns(3,4,5)P3)
K E Anderson, L R Stephens,, P T Hawkins
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Phosphoinositide 3-kinases and membrane traffic
Trends in Cell Biology, 1996Phosphoinositide 3-kinases (PI 3-kinases) and their 3-phosphoinositide products were identified initially as components of intracellular signalling pathways emanating from cell surface receptors. A new role for 3-phosphoinositides in the constitutive movement o f proteins from one intracellular compartment to another was proposed with the discovery of ...
P R, Shepherd +2 more
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Phosphoinositide 3‐kinases in cell migration
Biology of the Cell, 2009Cell migration is essential for many biological processes in animals and is a complex highly co‐ordinated process that involves cell polarization, actin‐driven protrusion and formation and turnover of cell adhesions. The PI3K (phosphoinositide 3‐kinase) family of lipid kinases regulate cell migration in many different cell types, both through direct ...
Cain, Robert J., Ridley, Anne J.
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Phosphoinositide 3-kinase in immunological systems
Seminars in Immunology, 2002Phosphoinositide 3-kinases (PI3Ks) are an evolutionarily conserved family of signal transducing enzymes. A great variety of stimuli activate PI3K, leading to the transient accumulation of its lipid products in cell membranes. These lipids serve as second messengers to regulate the location and activity of an array of downstream effector molecules.
David A, Fruman, Lewis C, Cantley
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Phosphoinositide (PI) 3-Kinase Assays
2008The regulation of phosphoinositide (PI) 3-kinase activities has been linked to many normal and disease-related processes, including cell survival, cell growth and proliferation, cell differentiation, cell motility, and intracellular vesicle trafficking.
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Phosphoinositide 3-Kinases—A Historical Perspective
2012The phosphoinositide 3-kinase (PI 3-K) signal relay pathway represents arguably one of the most intensely studied mechanisms by which extracellular signals elicit cellular responses through the generation of second messengers that are associated with cell growth and transformation.
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