Results 51 to 60 of about 18,679,675 (294)
Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan +6 morewiley +1 more sourcePartial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti +4 morewiley +1 more sourceMechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane +7 morewiley +1 more sourceEvaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk. [PDF]
, 2011 BACKGROUND: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph ...Dite, G S, S Chanock, Noh, D-Y., Severi, G., Sangrajrang, S., Hein, R, Yoo, K-Y, J Wang, Wang, J., Pooley, K A, Anton-Culver, H., Rogov, Y.I., A Ziogas, Hein, A, Kosma, V.M., Brock, I W, S Manoukian, Meindl, A., S Sangrajrang, Dunning, A.M., R L Milne, Bartrar, CR, R Winqvist, S S Cross, Perez, J.I.A., Anton Culver, H., Ekici, A. B., Garcia Closas, M., Noh, D.Y., G G Giles, M W Beckmann, Silva, I. dos Santos, Hopper, JL, Broeks, A., Vachon, C M, N Johnson, Hopper, J L, Humphreys, M K, Bruening, T., Wang-Gohrke, S., Tollenaar, Robert A. E. M., Cross, SS, Kosma, V-M, Johnson, N., Bonanni, B, Milne, R L, Vachon, CM, M Bremer, Sawyer, E, Kataja, V, Mulligan, A.M., Easton, D F, Kosma, V-M., Chenevix Trench, G., P Schürmann, A Miron, L Baglietto, Miron, A, Lindblom, A., E M John, I W Brock, McKay, J, Kang, D., Bogdanova, N, Johnson, N, Apicella, C., Garcia-Closas, M., Van 't Veer, L. J., Hartikainen, J, Pylkaes, K., G S Dite, P Brennan, Hopper, J. L., Van 't Veer, LJ, Pooley, KA, Fredericksen, Z, Milne, R.L., Hopper, J.L., Cox, A, Pooley, K. A., Hillemanns, P., Wang-Gohrke, S, Kerin, M.J., John, E M, Rogov, Y. I., Zalutsky, J. V., Olson, J, McLean, CA, Anton-Culver, H, G D Thomas, Pooley, K.A., Hunter, D J, Grip, M, V-M Kosma, A Meindl, X Wang, N Bogdanova, BAGLIETTO, LAURA, Tomlinson, I, E Sawyer, Giles, GG, A M Dunning, Antonenkova, N, Pérez, JA, Schmidt, M K, Giles, G G, N Antonenkova, B Bonanni, Pharoah, P.P., Southey, M C, Chenevix-Trench, G, Invest, kConFab, GENICA Network, Schmidt, M. K., Hunter, DJ, Knight, J.A., Ko, YD, Mulligan, A M, Baglietto, L, Rogov, YI, V Gabrieau, Couch, FJ, Beckmann, M W, Knight, J A, Fasching, PA, J Peto, Meindl, A, Severi, G, Gibson, L., Burwinkel, B., Y I Rogov, Benítez, J, J McKay, Tomlinson, Ian, John, E. M., P P Pharoah, Lissowska, J, Noh, DY, Brüning, T., D-Y Noh, Glendon, G., Peterlongo, P, Noh, D. Y., Fredericksen, Z., Milne, RL, Beckmann, MW, Cross, S.S., Kosel, M, Manoukian, S., Schürmann, P, Chanock, S., Cerhan, J, Jukkola-Vuorinen, A, Fasching, P A, Australian Ovarian Cancer Study Group, Hoover, R. N., Vachon, C. M., I Andrulis, Rogov, Y I, Schmidt, M.K., H Anton-Culver, Dörk, T., P Hillemanns, Giles, G.G., Ekici, A B, Hoover, R.N., Schmutzler, RK, F J Couch, Australian Ovarian Cancer Study Gr, Peto, J., C Apicella, Couch, F.J., Hillemanns, P, Mannermaa, A., Brock, I.W., J Chang-Claude, Pylkäs, K, Van 't Veer, L.J., Cross, S. S., Chen, X, Winqvist, R, Hamann, U., Chang-Claude, J., Brennan, P, Baglietto, L., Kosma, V. M., Beckmann, M. W., Veer, L.J. van 't, Wang, X., kConFab Invest, Van T Veer, LJ, Van 't Veer, L. J., Dite, GS, S Margolin, Couch, F J, Jukkola-Vuorinen, A., Bartrar, C R, Dörk, T, Bremer, M, Hein, A., Dunning, A M, D Kang, D J Hunter, Manoukian, S, González-Neira, A, Doerk, T., Benitez, J., Thomas, GD, Sawyer, E., Hamann, U, T Dörk, V Kataja, Thomas, G. D., Dunning, A. M., Milne, R. L., I dos Santos Silva, Ko, Y D, A González-Neira, Tomlinson, I., Zalutsky, J V, M Grip, McLean, C A, Apicella, C, Gonzalez-Neira, A., Schmutzler, R. K., Pharoah, P P, null null, I Tomlinson, G Glendon, Stevens, K N, L J Van ‘t Veer, Schuermann, P., R N Hoover, Mclean, C. A., John, EM, Bartrar, C.R., Hunter, D.J., Mulligan, AM, C R Bartrar, Wang, J, Fasching, P.A., Ekici, A.B., Southey, M. C., Van ‘t Veer, LJ, Ziogas, A, Zalutsky, JV, Lissowska, J., Wang, X, Hoover, RN, M Garcia-Closas, Dunning, AM, Broeks, A, Burwinkel, B, Brock, IW, John, E.M., Easton, DF, Knight, J. A., M K Humphreys, Antonenkova, N., J A Knight, Tollenaar, RAEM, Kang, D, Mulligan, A. M., Kerin, M. J., Chang Claude, J., K-Y Yoo, M C Southey, Giles, G. G., Miron, A., Olson, J., Vachon, C.M., Humphreys, MK, Southey, M.C., S Wang-Gohrke, Chang-Claude, J, J Olson, Sangrajrang, S, Mckay, J., A Cox, Silva, I.D.S., V S Pankratz, Brennan, P., A B Ekici, Noh, D-Y, Jukkola Vuorinen, A., X Chen, Bremer, M., Ziogas, A., Pankratz, V. S., G Elliott, Schmutzler, R.K., Cerhan, J., Ekici, AB, Group, AOCS, Couch, F. J, K N Stevens, Van ‘t Veer, L J, Network, GENICA, A Broeks, A Mannermaa, A Lindblom, L Bernard, Peto, J, dos Santos Silva, I, M Kosel, Bonanni, B., A Jukkola-Vuorinen, Elliott, G., B Burwinkel, L Gibson, Easton, D. F., Yoo, KY, Knight, JA, Z Fredericksen, Grip, M., Gabrieau, V, M J Kerin, Peterlongo, P., Hoover, R N, Beckmann, M.W., J Cerhan, Bogdanova, N., Schürmann, P., Couch, F. J., Yoo, K.Y., R K Schmutzler, Gibson, L, J L Hopper, Lindblom, A, J Benítez, Kosel, M., C M Vachon, G Severi, González Neira, A., Margolin, S., K A Pooley, Humphreys, M. K., Pharoah, P. P., Stevens, K. N., Southey, MC, Brüning, T, Pharoah, PP, Dite, G. S., P Peterlongo, Bartrar, C. R., Elliott, G, A Hein, Kerin, MJ, Yoo, K-Y., Hartikainen, J., Pérez, J. A., R A E M Tollenaar, Dite, G.S., JI Arias Pérez, Garcia-Closas, M, Kosma, VM, Tollenaar, RA, G Chenevix-Trench, Bernard, L., Brock, I. W., Kerin, M J, Pankratz, V S, dos Santos Silva, I., Thomas, G D, J Hartikainen, Stevens, K.N., A M Mulligan, Wang Gohrke, S., Perez, J. I. Arias, Y D Ko, D F Easton, Chanock, S, C A McLean, Humphreys, M.K., M K Schmidt, Gabrieau, V., Arias Pérez, JI, Andrulis, I, Margolin, S, Pankratz, VS, Stevens, KN, Zalutsky, J.V., Ko, Y. D., Mannermaa, A, McLean, C.A., Tollenaar, R. A. E. M., Tollenaar, R.A.E.M., Cox, A., Andrulis, I., Schmutzler, R K, R Hein, Winqvist, R., Cross, S S, Pankratz, V.S., P A Fasching, Chen, X., Easton, D.F., Bernard, L, Ko, Y.D., Pylkäs, K., J Lissowska, Hunter, D. J., Fasching, P. A., Yoo, K. Y., J V Zalutsky, Silva, I.D., Kataja, V., Chenevix-Trench, G., T Brüning, Glendon, G, U Hamann, Hein, R., Thomas, G.D., Van T. Veer, L. J., K Pylkäs, Schmidt, MK, kConFab Investigators, Pérez, JI Arias, Hunter, David, Tollenaar, R A E M +419 morecore +1 more sourceThe VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi +2 morewiley +1 more source
