Results 81 to 90 of about 18,679,675 (294)

Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway

Neural Regeneration Research
Recombinant tissue plasminogen activator is commonly used for hematoma evacuation in minimally invasive surgery following intracerebral hemorrhage. However, during minimally invasive surgery, recombinant tissue plasminogen activator may come into contact
Jie Jing, Shiling Chen, Xuan Wu, Jingfei Yang, Xia Liu, Jiahui Wang, Jingyi Wang, Yunjie Li, Ping Zhang, Zhouping Tang   +9 more
doaj   +1 more source

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source

PI3Kγδ inhibition suppresses key disease features in a rat model of asthma

Respiratory Research
Background Two isoforms of Phosphoinositide 3-kinase (PI3K), p110γ and p110δ, are predominantly expressed in leukocytes and represent attractive therapeutic targets for the treatment of allergic asthma.
James W. Pinkerton, Silvia Preite, Antonio Piras, Dimitrios Zervas, Thomais Markou, Mark S. Freeman, Tobias Hofving, Emil Ivarsson, Sara J. Bonvini, Wayne Brailsford, Linda Yrlid, Maria G. Belvisi, Mark A. Birrell   +12 more
doaj   +1 more source

An updated review on activated PI3 kinase delta syndrome (APDS)

Genes and Diseases, 2020
Activated Phosphoinositide 3-kinase δ syndrome (APDS) is a newly recognised primary immunodeficiency disease. It has currently been a hot topic of clinical research and new data are emerging regarding its pathogenesis, clinical manifestations and ...
Ankita Singh, Vibhu Joshi, Ankur Kumar Jindal, Babu Mathew, Amit Rawat   +4 more
doaj   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila [PDF]

, 2008
Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3)) – kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear.
Backer, J. M., Baehrecke, EH, Miklós Sass, Hill, JH, Ying Yan, Hill, J. H., Sass, Miklós, Jahda H. Hill, Backer, JM, Gábor Juhász, Thomas P. Neufeld, Jonathan M. Backer, Baehrecke, E. H., Yan, Y, Neufeld, TP, Juhász, Gábor, Yan, Y., Neufeld, T. P., Eric H. Baehrecke   +18 more
core   +1 more source

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer

Journal of Experimental & Clinical Cancer Research, 2019
Background The very aggressive nature and low survival rate of pancreatic ductal adenocarcinoma (PDAC) dictates the necessity to find novel efficacious therapies.
Aikaterini Emmanouilidi, Chanse A. Fyffe, Riccardo Ferro, Charlotte E. Edling, Emily Capone, Simona Sestito, Simona Rapposelli, Rossano Lattanzio, Stefano Iacobelli, Gianluca Sala, Tania Maffucci, Marco Falasca   +11 more
doaj   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase

Cancer Cell International, 2019
Background Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities and properties.
Jingxian Liu, Jinghong Yang, Yuhe Hou, Zhenwei Zhu, Jie He, Hao Zhao, Xidong Ye, Dengke Li, Zhaohui Wu, Zhongxi Huang, Bingtao Hao, Kaitai Yao   +11 more
doaj   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source