Results 101 to 110 of about 116,122 (261)
Lipid levels in sperm, eggs, and during fertilization in Xenopus laevis
Journal of Lipid Research, 2008 Critical developmental periods, such as fertilization, involve metabolic activation, membrane fusion events such as sperm-egg or plasma membrane-cortical granule merger, and production and hydrolysis of phospholipids.
Douglas W. Petcoff +2 more
doaj +1 more source
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]
, 1994 Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M +7 more
core +2 more sources
Lipids, EarlyView.ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao +5 more
wiley +1 more source
Positional specificity of lysosomal phospholipase A2
Journal of Lipid Research, 2006 Lysosomal phospholipase A2 (Lpla2) is highly expressed in alveolar macrophages and may mediate the phospholipid metabolism of surfactant. Studies on the properties of this phospholipase are consistent with the presence of both phospholipase A1 and ...
Akira Abe +2 more
doaj +1 more source
Obesity, EarlyView.Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...
Joan Duran‐Bertran +11 more
wiley +1 more source
Secreted phospholipase A2 and mast cells
Allergology International, 2015 Phospholipase A2s (PLA2s) are a group of enzymes that hydrolyze the sn-2 position of phospholipids to release (typically unsaturated) fatty acids and lysophospholipids, which serve as precursors for a variety of bioactive lipid mediators.
Makoto Murakami, Yoshitaka Taketomi
doaj +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Objective Amnioinfusions in anhydramnios aim to promote fetal lung development, but currently used fluids (Normal Saline [NS], Lactated Ringer's [LR]) fail to mimic the intrauterine environment and increase reactive oxygen species (ROS). We developed a synthetic amniotic fluid (Amnio‐well, AW) designed to reduce intrauterine ROS.
Braxton Forde +3 more
wiley +1 more source
Phospholipase A2 structure/function, mechanism, and signaling1
Journal of Lipid Research, 2009 Tremendous advances in understanding the structure and function of the superfamily of phospholipase A2 (PLA2) enzymes has occurred in the twenty-first century.
John E. Burke, Edward A. Dennis
doaj +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley +1 more source
Journal of Lipid Research, 1999 Lysophosphatidylcholine (lyso-PC) and arachidonate are products of phosphatidylcholine hydrolysis by phospholipase A2. In this study, the modulation of arachidonate release by exogenous lyso-PC in rat heart myoblastic H9c2 cells was examined.
Leonard S. Golfman +6 more
doaj +1 more source