Diagnosis of snake envenomation using a simple phospholipase A2 assay
Scientific Reports, 2014 Diagnosis of snake envenomation is challenging but critical for deciding on antivenom use. Phospholipase A2 enzymes occur commonly in snake venoms and we hypothesized that phospholipase activity detected in human blood post-bite may be indicative of ...
K. Maduwage, M. O’Leary, G. Isbister
semanticscholar +1 more source
Tetracycline Actions Relevant to Rosacea Treatment [PDF]
, 2009 Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Korting, Hans Christian, Schöllmann, C.
core +1 more source
Phospholipase A2 Activates Hemostasis
Drug Target Insights, 2007 Background: Phospholipases A2 (PLA2) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein—mediated contact phase of coagulation.
Thomas W. Stief
doaj
Function of the fully conserved residues Asp99, Tyr52 and Tyr73 in phospholipase A2 [PDF]
, 1990 In the active centre of pancreatic phospholipase A2 His48 is at hydrogen-bonding distance to Asp99. This Asp-His couple is assumed to act together with a water molecule as a catalytic triad. Asp99 is also linked via an extended hydrogen bonding system to
Franken, Peet A. +4 more
core +3 more sources
Cytosolic Phospholipase A2 Protein as a Novel Therapeutic Target for Spinal Cord Injury
Annals of Neurology, 2014 The objective of this study was to investigate whether cytosolic phospholipase A2 (cPLA2), an important isoform of PLA2 that mediates the release of arachidonic acid, plays a role in the pathogenesis of spinal cord injury (SCI).
Nai-Kui Liu +9 more
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2011 Involvement of secretory phospholipase A2 (sPLA2) in the stretch-induced production of untransformed prostaglandin H2 (PGH2) in the endothelium of rabbit pulmonary arteries was investigated.
Yoshiyuki Tanabe +6 more
doaj +1 more source
Identification of residues involved in substrate specificity and cytotoxicity of two closely related cutinases from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2013 The enzymes belonging to the cutinase family are serine enzymes active on a large panel of substrates such as cutin, triacylglycerols, and phospholipids. In the M.
Luc Dedieu +2 more
doaj +1 more source
Molecular Characterization of Three Novel Phospholipase A2 Proteins from the Venom of Atheris chlorechis, Atheris nitschei and Atheris squamigera [PDF]
, 2016 Secretory phospholipase A2 (sPLA2) is known as a major component of snake venoms and displays higher-order catalytic hydrolysis functions as well as a wide range of pathological effects.
Chen, Tianbao +5 more
core +2 more sources
Phospholipase A2 and inflammation
Molecular Medicine Today, 1995 Increased expression of secreted group II phospholipase A 2 (sPLA2) is associated with inflammation 1.This enzyme can promote a variety of potentially harmful events, which have been attributed to its catalytic activity. However, the possibility that sPLA 2 may also exert actions that do not depend on its catalytic activity has generally not been ...
Lomonte, Bruno +2 more
openaire +4 more sources
Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. [PDF]
, 2017 Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain.
Bazinet, Richard P +11 more
core +1 more source