Results 141 to 150 of about 40,217 (258)
Advanced Science, Volume 13, Issue 32, 9 June 2026.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
Advances in the pathogenesis and clinical applications of PLA2R-associated membranous nephropathy
Linchuang shenzangbing zazhiMembranous nephropathy is one of the main pathological types of nephrotic syndrome. PLA2R（phospholipase A2 receptor）associated membranous nephropathy is the predominant type of primary membranous nephropathy， also known as idiopathic membranous ...
Sun Miao-xin +9 more
doaj
The Emerging Parkinson's Disease Oxylipin‐Ome
Advanced Science, Volume 13, Issue 33, 15 June 2026.ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley +1 more source
Effects Of Morin On Snake Venom Phospholipase A2 (pla 2)
, 2015 Flavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and have been used experimentally against inflammatory processes.
Beriam L.O.S. +9 more
core +1 more source
Comprehensive Physiology, Volume 16, Issue 3, June 2026.This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni +3 more
wiley +1 more source
Multi‐Omics Analyses Elucidate the Venom Components of the Wasp Vespa mandarinia
Ecology and Evolution, Volume 16, Issue 6, June 2026.The wasp Vespa mandarinia was widely reared in Yunnan province. The venom was responsible for their aggressive behavior. Tweety proteases, hyaluronidase, venom dipeptidyl peptidase 4, and phospholipase A1 and A2 isozyme were identified. In addition, organic heterocyclic compounds, organic acids, and derivatives were found.
Yuan‐Chong Shi +4 more
wiley +1 more source
Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
eFood, Volume 7, Issue 3, June 2026.Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.This study elucidates the multi‐targeted mechanisms of Virgin Coconut Oil (CO) as a dietary intervention for ameliorating Diabetic Kidney Disease (DKD). High‐purity medium‐chain fatty acids (MCFAs, primarily octanoic acid [C8:0] and decanoic acid [C10:0]) in CO significantly remodel the gut microbiota by enriching short‐chain fatty acid (SCFA ...
Keke Shao +13 more
wiley +1 more source
Anti-phospholipase A2 Receptor Antibody-Negative Membranous Nephropathy in Pregnancy. [PDF]
Cureus, 2023 Saleem M, Iftikhar H.
europepmc +1 more source