Results 141 to 150 of about 1,619,431 (240)
Structural dynamics and pH‐regulated membrane binding of the TRAF2‐NC trimer
Protein Science, Volume 35, Issue 11, November 2026.Abstract Tumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key adaptor in TNF receptor‐signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor‐binding domains (TRAF2‐NC, residues 266–501).
Federica Cossu +9 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 11, November 2026.ABSTRACT Fatty acid oxidation (FAO) is a metabolic vulnerability in cancer cells, making pharmacologic FAO inhibition a promising therapeutic strategy. This Phase I, open‐label, 3 + 3 dose‐escalation study evaluated the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of two oral FAO inhibitors—omeprazole (KN510), a carnitine ...
Wonyoung Choi +11 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10670-10682, November 2026.ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk +18 more
wiley +1 more source
Updates on intra‐articular corticosteroid administration in horses
Equine Veterinary Education, Volume 38, Issue 11, Page 600-610, November 2026.Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner +5 more
wiley +1 more source
Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?
Experimental Dermatology, Volume 35, Issue 11, November 2026.ABSTRACT Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and ...
Ines Martic +14 more
wiley +1 more source
Anti-phospholipase A2 Receptor Antibody-Negative Membranous Nephropathy in Pregnancy. [PDF]
Cureus, 2023 Saleem M, Iftikhar H.
europepmc +1 more source
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.A maternal western diet (WD) and betaine supplementation during suckling influence metabolic programming. A maternal WD induced adverse metabolic effects in offspring, accompanied by altered FGF21‐related gene expression and decreased Akkermansia muciniphila abundance.
Rocío A. Martín‐Chamorro +4 more
wiley +1 more source
Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers
ChemMedChem, Volume 21, Issue 20, 28 October 2026.Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley +1 more source
Beyond Titers: Phospholipase A2 Receptor Epitope Complexity as a New Lens in Membranous Nephropathy. [PDF]
J Am Soc NephrolAl-Rabadi L, Avasare RS.
europepmc +1 more source