Results 131 to 140 of about 40,217 (258)

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1403-1426, July 2026.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

HIV et exosomes : rôle de l'homéostasie lipidique du compartiment endosomal dans le maintien des réservoirs du HIV

, 2010
Les exosomes sont des vésicules de 50-90 nm, générées dans le compartiment endosomal tardif, ou corps multivésiculaires, et sécrétés dans le milieu extracellulaire par les cellules vivantes.
Subra, Caroline
core  

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais, Rajendra Rohokale, Sevin Mamputu, Ion Lupu, Zhongwu Guo, Sébastien Balieu   +5 more
wiley   +1 more source

Caracterização farmacológica e molecular dos mecanismos envolvidos no edema de pata induzido pela prostaglandina E2 (PGE2) [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.
Claudino, Rafaela Franco
core  

sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor

, 2014
The M-type phospholipase A2 receptor (PLA2R) is expressed in podocytes in human glomeruli. Group IB secretory phospholipase A2 (sPLA2 IB), which is one of the ligands of the PLA2R, is more highly expressed in chronic renal failure patients than in ...
Wan, J. X., Yang, Qian, Pan, Yangbin, Ding, G. H., Yang, Q., Liu, Yipeng, Liu, Y. P., Pan, Y. B., Singhal, Pravin C, Saleem, Moin A, Liang, W., Saleem, M. A., Liang, Wei, Ding, Guohua, Wan, Jianxin, Singhal, P. C.   +15 more
core   +1 more source

The study of correlation between serum anti-phospholipase A2 receptor antibody and clinicopathology feature and the efficacy in patients with idiopathic membranous nephropathy

Linchuang shenzangbing zazhi, 2020
Objective To assess the correlation between serum anti-phospholipase A2 receptor（PLA2 R） antibody and clinicopathology and the effect of serum anti-phospholipase A2 receptor antibody on the patients with idiopathic membranous nephropathy（IMN）.Methods ...
LI Wen-dong, WANG Jing, ZHANG Yan-qin, WANG Hai-sheng, GAO Ying-ying   +4 more
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Characterisation of PLD activity in real-time [PDF]

PLD catalyses hydrolysis of phosphatidylcholine (PtdCho) to produce phosphatidic acid (PtdOH) and choline. PtdOH is a second messenger responsible for a multitude of cell processes, ranging from cytoskeletal rearrangement to cell proliferation ...
Aletrari, Mina-Olga
core  

G-Protein Beta-Gamma-Subunits Activate the Cardiac Muscarinic K+-Channel Via Phospholipase-A2

, 1989
Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein.
Deborah L. Lewis, Barsagi, D., Eva J. Neer, Kim, D., Lewis, D. L., Neer, E. J., Graziadei, L., Clapham, D. E., David E. Clapham, Donghee Kim, Linda Graziadei, Dafna Bar-Sagi   +11 more
core   +1 more source