Results 111 to 120 of about 40,300 (234)

HIV et exosomes : rôle de l'homéostasie lipidique du compartiment endosomal dans le maintien des réservoirs du HIV [PDF]

, 2010
Les exosomes sont des vésicules de 50-90 nm, générées dans le compartiment endosomal tardif, ou corps multivésiculaires, et sécrétés dans le milieu extracellulaire par les cellules vivantes.
Subra, Caroline
core  

Early transcriptional response in the jejunum of germ-free piglets after oral infection with virulent rotavirus [PDF]

, 2008
Germ-free piglets were orally infected with virulent rotavirus to collect jejunal mucosal scrapings at 12 and 18 hours post infection (two piglets per time point).
Hulst, M.M., Wit, A.A.C., de, van der Meulen, J., Niewold, T., Meulen, J., van der, de Wit, A.A.C., Smits, M.A., Kerstens, H.H.D.   +7 more
core   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor [PDF]

, 2014
The M-type phospholipase A2 receptor (PLA2R) is expressed in podocytes in human glomeruli. Group IB secretory phospholipase A2 (sPLA2 IB), which is one of the ligands of the PLA2R, is more highly expressed in chronic renal failure patients than in ...
Wan, J. X., Yang, Qian, Pan, Yangbin, Ding, G. H., Yang, Q., Liu, Yipeng, Liu, Y. P., Pan, Y. B., Singhal, Pravin C, Saleem, Moin A, Liang, W., Saleem, M. A., Liang, Wei, Ding, Guohua, Wan, Jianxin, Singhal, P. C.   +15 more
core   +2 more sources

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Real-World Utility of Immunoglobulin G4 Subtype Phospholipase A2 Receptor Autoantibodies in Diagnosing Phospholipase A2 Receptor–Associated Membranous Nephropathy

Archives of Pathology & Laboratory Medicine
Context.— The role of anti–phospholipase A2 receptor (PLA2R) antibody (PLA2R-immunoglobulin [Ig] G) in management of membranous nephropathy (MN) is important. However, information regarding the value of its main subtype, PLA2R-IgG4, is limited. Objective.—
Yongzhong, Zhong, Yunyun, Liu, Dacheng, Chen, Yujie, Tang, Dandan, Liang, Tianyu, Zheng, Biao, Huang, Caihong, Zeng   +7 more
openaire   +2 more sources

The characterisation of Plc1 : a phospholipase C enzyme identified in the fission yeast Schizosaccharomyces pombe [PDF]

The plc1 gene product (Plc1) of the fission yeast Schizosaccharomycespombe (Sz. pombe) encodes a phosphoinositide-specific phospholipase C (PLC) and most closely resembles the δ class of the PLC isozymes.
Brind, Robert Ian
core  

G-Protein Beta-Gamma-Subunits Activate the Cardiac Muscarinic K+-Channel Via Phospholipase-A2 [PDF]

, 1989
Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein.
Deborah L. Lewis, Barsagi, D., Eva J. Neer, Kim, D., Lewis, D. L., Neer, E. J., Graziadei, L., Clapham, D. E., David E. Clapham, Donghee Kim, Linda Graziadei, Dafna Bar-Sagi   +11 more
core   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Wolfgang Siess, Siess, Wolfgang
core   +1 more source