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Advances in Experimental Medicine and Biology, 2019 Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate various functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times
Colin A, Bill, Charlotte M, Vines
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The Phospholipase C Isozymes and Their Regulation [PDF]
Sub-cellular biochemistry, 2012 The physiological effects of many extracellular neurotransmitters, hormones, growth factors, and other stimuli are mediated by receptor-promoted activation of phospholipase C (PLC) and consequential activation of inositol lipid signaling pathways. These signaling responses include the classically described conversion of phosphatidylinositol(4,5)P(2) to
Aurelie Gresset +2 more
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Effect of the Hemolysin of Pseudomonas aeruginosa on Phosphatides and on Phospholipase c Activity [PDF]
Journal of Bacteriology, 1967 Susumu Kurioka, Pinghui V. Liu
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PTEN regulates phospholipase D and phospholipase C [PDF]
Human Molecular Genetics, 2007 PTEN is an ubiquitously expressed tumor suppressor which plays a prominent role in the pathogenesis of many types of sporadic solid tumors, including breast cancer, as well as hematologic malignancies. Germline PTEN mutations cause 85% of Cowden syndrome (CS), characterized by a high risk of breast and thyroid cancers, and 65% of Bannayan-Riley ...
Charis Eng +3 more
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Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice
Scientific Reports, 2018 Sperm entry in mammalian oocytes triggers intracellular Ca2+ oscillations that initiate resumption of the meiotic cell cycle and subsequent activations.
K. Nozawa +4 more
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Bacterial phospholipases C [PDF]
Microbiological Reviews, 1993 A variety of pathogenic bacteria produce phospholipases C, and since the discovery in 1944 that a bacterial toxin (Clostridium perfringens alpha-toxin) possessed an enzymatic activity, there has been considerable interest in this class of proteins. Initial speculation that all phospholipases C would have lethal properties has not been substantiated ...
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Phosphoinositide-specific phospholipase C in health and disease
Journal of Lipid Research, 2015 Phospholipases are widely occurring and can be found in several different organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) is a class of phospholipases that cleaves phospholipids on the diacylglycerol (DAG) side ...
L. Cocco, M. Follo, L. Manzoli, P. Suh
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PLoS Genetics, 2015 Phosphoinositides represent important lipid signals in the plant development and stress response. However, multiple isoforms of the phosphoinositide biosynthetic genes hamper our understanding of the pivotal enzymes in each step of the pathway as well as
K. Kanehara +7 more
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Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1
PLoS ONE, 2013 Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms.
P. Zygmunt +12 more
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