Results 1 to 10 of about 19,636,220 (230)
Advances in Experimental Medicine and Biology, 2019 Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate various functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times
Colin A. Bill, C. Vines
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Phospholipase C: underrated players in microbial infections [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 During bacterial infections, one or more virulence factors are required to support the survival, growth, and colonization of the pathogen within the host, leading to the symptomatic characteristic of the disease.
Vinayak Singh +6 more
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Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target [PDF]
Molecules, 2023 Phosphatidylcholine-specific phospholipase C (PC-PLC) is an enzyme that catalyzes the formation of the important secondary messengers phosphocholine and diacylglycerol (DAG) from phosphatidylcholine.
Chatchakorn Eurtivong +4 more
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Phospholipase C is a novel regulator at the early stages of microspore embryogenesis in Nicotiana tabacum [PDF]
Plant Signaling & Behavior, 2022 Microspore transfers the developmental fate into embryogenesis in vitro regulated by determinant factors of stress-induced. However, the key regulators of microspore embryogenesis (ME) are still largely undiscovered to reveal the mechanism of cell fate ...
Pan Luo +7 more
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Successful Production of Offspring Derived from Phospholipase C Zeta-Deficient Sperm by Additional Artificial Activation [PDF]
Life, 2023 During mammalian fertilization, repetitive rises of intracellular calcium called calcium oscillations are required for full activation of oocytes. Therefore, oocytes such as round spermatid injected or somatic cell nuclear transferred require additional ...
Naoki Hirose +9 more
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Effect of the Hemolysin of Pseudomonas aeruginosa on Phosphatides and on Phospholipase c Activity [PDF]
Journal of Bacteriology, 1967 The hemolysin of Pseudomonas aeruginosa was found to function as a detergent in solubilizing various phosphatides. Incorporation of the hemolysin into reaction mixtures containing phosphatides and phospholipase c significantly increased the rates of ...
S. Kurioka, P. Liu
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Phosphoinositide-specific phospholipase C in health and disease
Journal of Lipid Research, 2015 Phospholipases are widely occurring and can be found in several different organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) is a class of phospholipases that cleaves phospholipids on the diacylglycerol (DAG) side ...
Lucio Cocco +3 more
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Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. [PDF]
PLoS ONE, 2013 Phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate generates diacylglycerol, inositol 1,4,5-trisphosphate and protons, all of which can regulate TRPV1 activity via different mechanisms.
Peter M Zygmunt +12 more
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Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C [PDF]
Nature Communications, 2023 Non-specific phospholipase C (NPC) is a plant-specific phospholipid-hydrolyzing enzyme. Here, the authors define the molecular basis of how Arabidopsis NPC works, and provide new mechanistic insights into the members of phospholipase family.
Ruyi Fan +11 more
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Activation Mechanisms and Diverse Functions of Mammalian Phospholipase C [PDF]
Biomolecules, 2023 Phospholipase C (PLC) plays pivotal roles in regulating various cellular functions by metabolizing phosphatidylinositol 4,5-bisphosphate in the plasma membrane. This process generates two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol,
Kaori Kanemaru, Yoshikazu Nakamura
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