Results 91 to 100 of about 19,781,572 (286)

The Use of Synaptic Extracellular Myo‐Inositol to Treat Developmental and Epileptic Encephalopathy

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective The developmental and epileptic encephalopathies (DEE) are associated with serious and lifelong neurological conditions and risk of early mortality. Here, we describe the chronic treatment of a boy with PLCB1‐related DEE with enteral myo‐inositol supplementation as an add‐on therapy to standard antiseizure medications that had been ...
E. Naomi Vos, Didem Demirbas, Lance Rodan, Edward Yang, Sanjay P. Prabhu, Jie Chen, Xiaoping Huang, Wanshu Qi, Robin L. Haynes, Maria K. Lehtinen, Michael J. Bennett, Miao He, Phillip L. Pearl, M. Estela Rubio‐Gozalbo, Annapurna Poduri, Gerard T. Berry   +15 more
wiley   +1 more source

IN VITRO AGGREGATION OF PLATELETS INDUCED BY ^|^alpha;-TOXIN (PHOSPHOLIPASE C) OF CLOSTRIDIUM PERFRINGENS

, 1976
Takao Sugahara, Tomoko Takahashi, Shun‐ichi Yamaya, Akira Ohsaka   +3 more
openalex   +2 more sources

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

Enzymatic Hydrolysis of Sphingosylphosphorylcholine by Phospholipase C

, 1971
Takashi Negishi, Seisuke ITO, Yasuhiko Fujino   +2 more
openalex   +2 more sources

Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target. [PDF]

Molecules, 2023
Eurtivong C, Leung E, Sharma N, Leung IKH, Reynisson J.   +4 more
europepmc   +1 more source

Bio‐Based Solvents Extraction and Enzyme‐assisted Recovery of Furan Fatty Acid From Ammonia‐Stabilized Hevea Latex

European Journal of Lipid Science and Technology, EarlyView.
The latex of Hevea brasiliensis is rich in furan fatty acid (FuFA) esterified in both neutral and polar lipids. Bio‐based solvents to extract FuFA from ammonia‐stabilized latex was tested. Ethyl acetate worked best, especially with low‐ammonia content. Isopropanol was a good alternative. Lipases could also help to efficiently release FuFA. The findings
Chaisiri Kitpaosong, Siriluck Liengprayoon, Tucksin Lerksamran, Kittipong Rattanaporn, Bruno Barea, Achille Marchand, Frédéric Carrière, Hélène Launay, Thongchai Khaeduang, Pisamai Chantuma, Laurent Vaysse, Erwann Durand   +11 more
wiley   +1 more source

Effect of Phospholipase C Hydrolysis of Membrane Phospholipids on Membranous Enzymes

, 1972
Richard D. Mavis, Robert M. Bell, P. Roy Vagelos   +2 more
openalex   +1 more source

Phospholipase C: underrated players in microbial infections. [PDF]

Front Cell Infect Microbiol, 2023
Singh V, Rai R, Mathew BJ, Chourasia R, Singh AK, Kumar A, Chaurasiya SK.   +6 more
europepmc   +1 more source

The Reactivity of α‐Fluorinated Mono‐ and Diketones Uncovers their Potential as Electrophilic Warheads for Reversible Covalent Drugs

European Journal of Organic Chemistry, EarlyView.
The potential of fluorinated mono‐ and diketones as electrophilic warheads for reversible covalent drugs is described by studying their equilibria reactions with the protected nucleophilic amino acids serine, cysteine and lysine. Fluorinated diketones (FDKs) are electrophilic moieties holding unique molecular properties that make them potential ...
Yossi Zafrani, Ido Michael Herzog, Eliav Blum, Shlomi Elias, Sigal Saphier, Ishay Columbus   +5 more
wiley   +1 more source

Structural Insights into Phospholipase C-β Function

Molecular Pharmacology, 2013
A. Lyon, J. Tesmer
semanticscholar   +1 more source