Results 121 to 130 of about 133,836 (210)

Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases. [PDF]

J Adv Res
Wang J, Gao T, Zhang D, Tang Y, Gu J.
europepmc   +1 more source

Phospholipase C: Diverse functions in plant biotic stress resistance and fungal pathogenicity. [PDF]

Mol Plant Pathol, 2023
Fang Y, Jiang J, Ding H, Li X, Xie X.
europepmc   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C-induced mechanical hypersensitivity. [PDF]

Proc Natl Acad Sci U S A
Tobori S, Tamada K, Uemura N, Sawada K, Kakae M, Nagayasu K, Nakagawa T, Mori Y, Kaneko S, Shirakawa H.   +9 more
europepmc   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Mammalian PI-Phospholipase C Isozymes: Structural and Functional Insights and Roles in Health and Disease. [PDF]

Medicina (Kaunas)
Hamdi M, Al-Matwi M, Elghoul N, Al-Kuwari H, Sayed TS, Riguene E, Nomikos M.   +6 more
europepmc   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

The non-specific phospholipase C of common bean PvNPC4 modulates roots and nodule development. [PDF]

PLoS One
Pacheco R, Juárez-Verdayes MA, Chávez-Martínez AI, Palacios-Martínez J, Leija A, Nava N, Cárdenas L, Quinto C.   +7 more
europepmc   +1 more source

Clostridium perfringens phospholipase C, an archetypal bacterial virulence factor, induces the formation of extracellular traps by human neutrophils. [PDF]

Front Cell Infect Microbiol, 2023
Badilla-Vargas L, Pereira R, Molina-Mora JA, Alape-Girón A, Flores-Díaz M.   +4 more
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, EarlyView.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source