Results 131 to 140 of about 133,836 (210)

Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK. [PDF]

Exp Mol Med
Lee DK, Jin X, Choi PR, Cui Y, Che X, Lee S, Hur K, Kim HJ, Choi JY.   +8 more
europepmc   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, EarlyView.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease. [PDF]

Immunity, 2023
Tsai AP, Dong C, Lin PB, Oblak AL, Viana Di Prisco G, Wang N, Hajicek N, Carr AJ, Lendy EK, Hahn O, Atkins M, Foltz AG, Patel J, Xu G, Moutinho M, Sondek J, Zhang Q, Mesecar AD, Liu Y, Atwood BK, Wyss-Coray T, Nho K, Bissel SJ, Lamb BT, Landreth GE.   +24 more
europepmc   +1 more source

Phospholipase C Zeta 1 (PLCZ1): The Function and Potential for Fertility Assessment and In Vitro Embryo Production in Cattle and Horses. [PDF]

Vet Sci, 2023
Gonzalez-Castro RA, Carnevale EM.
europepmc   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in <i>Trypanosoma cruzi</i>. [PDF]

mBio
Bertolini MS, Cline SE, Chiurillo MA, Mantilla BS, Eidex A, Crowe LP, Qiu D, Jessen HJ, Saiardi A, Docampo R.   +9 more
europepmc   +1 more source

Involvement of Phospholipase C in Photosynthesis and Growth of Maize Seedlings. [PDF]

Genes (Basel), 2022
Wei Y, Liu X, Ge S, Zhang H, Che X, Liu S, Liu D, Li H, Gu X, He L, Li Z, Xu J.   +11 more
europepmc   +1 more source

Updates on intra‐articular corticosteroid administration in horses

Equine Veterinary Education, EarlyView.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner, L. Bass, C. Kawcak, L. V. Schnabel, K. L. Hallowell, L. M. Pezzanite   +5 more
wiley   +1 more source

Small peptides derived from the autoinhibitory XY linker of phospholipase C-β isoforms inhibit enzyme activity and reduce inflammation.

Biomed Pharmacother
de Andrés-López J, Cabañero D, Devesa I, Shah S, Fernández-Ballester G, Gamper N, Ángeles Bonache M, González-Muñiz R, Fernández-Carvajal A, Ferrer-Montiel A.   +9 more
europepmc   +1 more source

U-73122, a phospholipase C inhibitor, impairs lymphocytic choriomeningitis virus virion infectivity. [PDF]

J Gen Virol
Mizuma K, Hashizume M, Urata S, Shindo K, Takashima A, Mizuta S, Iwasaki M.   +6 more
europepmc   +1 more source