Results 151 to 160 of about 245,381 (200)
Some of the next articles are maybe not open access.
A simplified assay for phospholipase C
Analytical Biochemistry, 1979Abstract A new assay for phospholipase C activity that uses alkaline phosphatase to convert phosphorylcholine to inorganic phosphate is described. The determination of inorganic phosphate is performed in the presence of phosphatidylcholine and protein after the addition of sodium dodecyl sulfate.
E L, Krug, N J, Truesdale, C, Kent
openaire +2 more sources
Selective phospholipase C activation
BioEssays, 1991AbstractPhospholipase C is a family of cellular proteins believed to play a significant role in the intracellular signaling mechanisms utilized by diverse hormones. One class of hormones, polypeptide growth factors, elicits its influence on cellular function through stimulation of cell surface receptor tyrosine kinase activity.
M, Wahl, G, Carpenter
openaire +2 more sources
Toxicity of phospholipase C in rabbits
Scandinavian Journal of Clinical and Laboratory Investigation, 1982Tissue thromboplastin is the most potent physiological trigger of blood coagulation and is probably involved in the pathogenesis of several forms of intravascular coagulation. Phospholipase C from Bacillus cereus is an effective inhibitor of thromboplastin.
O, Hetland +4 more
openaire +2 more sources
The effect of phospholipase C in sheep
Scandinavian Journal of Clinical and Laboratory Investigation, 1983Based on earlier studies in rats, phospholipase C (PLC) seemed to be a very promising prophylactic agent for certain types of thrombo-embolic disease. Recent studies in rabbits have, however, demonstrated that phospholipase C is more toxic than expected from the previous data.
E, Carlsen, O, Hetland, C F, Lindboe
openaire +2 more sources
The physiological roles of primary phospholipase C
Advances in Biological Regulation, 2013The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively investigated in diverse cell lines and pathological conditions. Among the PLC isozmes, primary PLCs, PLC-β and PLC-γ, are directly activated by receptor activation, unlike other secondary PLCs (PLC-ɛ, PLC-δ1, and PLC-η1).
Yang YR +3 more
openaire +3 more sources
2003
Publisher Summary This chapter provides an overview of mammalian phospholipase C. The hydrolysis of cellular phospholipids leads to the formation of various bioactive lipid mediators, acting either as extracellular signaling molecules or as intracellular second messengers. A well-known second messenger-forming system involving phospholipid hydrolysis
Martina Schmidt +4 more
openaire +1 more source
Publisher Summary This chapter provides an overview of mammalian phospholipase C. The hydrolysis of cellular phospholipids leads to the formation of various bioactive lipid mediators, acting either as extracellular signaling molecules or as intracellular second messengers. A well-known second messenger-forming system involving phospholipid hydrolysis
Martina Schmidt +4 more
openaire +1 more source
Phospholipases C and Phospholipases D of Mammalian Cells
1987As with Chapters 6 and 7, which covered mammalian acyl hydrolases, emphasis is on the characterization and purification of the mammalian phosphodiesterases; studies on their physiologic roles are covered in Chapter 11.
openaire +1 more source
Gan to kagaku ryoho. Cancer & chemotherapy, 1997
N-Myristoylated PCI peptide, myr-PCI, originally developed based on the PCI sequence of PLC- gamma 2, inhibited activity of purified PLC isoforms in vitro, and external stimuli-dependent IP3 formation in Swiss 3T3 cells. When myr-PCI was added to KMS-8 cells, derived from familial adenomatous polyposis patients, it also suppressed the serum-dependent ...
Y, Homma, M, Homma
openaire +1 more source
N-Myristoylated PCI peptide, myr-PCI, originally developed based on the PCI sequence of PLC- gamma 2, inhibited activity of purified PLC isoforms in vitro, and external stimuli-dependent IP3 formation in Swiss 3T3 cells. When myr-PCI was added to KMS-8 cells, derived from familial adenomatous polyposis patients, it also suppressed the serum-dependent ...
Y, Homma, M, Homma
openaire +1 more source
[Phospholipase C and reproduction].
Zhonghua nan ke xue = National journal of andrology, 2004Phospholipase C (PLC) is a key enzyme in phosphatidyl inositol turnover during signal transduction. The 12 mammalian PLC isozymes identified to date can be divided into five subtypes, beta-type, gamma-type, delta-type, epsilon-type and zeta-type, with extensive difference in structure, regulatory mechanism and tissue distribution.
Aihua, Gu, Zuomin, Zhou, Jiahao, Sha
openaire +1 more source