Results 161 to 170 of about 242,802 (301)

Emerging Roles of Phospholipase C Beta Isozymes as Potential Biomarkers in Cardiac Disorders. [PDF]

Int J Mol Sci, 2023
Fazio A, Evangelisti C, Cappellini A, Mongiorgi S, Koufi FD, Neri I, Marvi MV, Russo M, Ghigo A, Manzoli L, Fiume R, Ratti S.   +11 more
europepmc   +1 more source

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, EarlyView.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

Immobilized <i>Staphylococcus aureus</i> phospholipase C on calcium alginate-chitosan: improved performance and industrial potential in soybean oil refining. [PDF]

Front Bioeng Biotechnol
Alzahrani AA, Krayem N, Alonazi M, Al-Shehri E, Horchani H, Ben Bacha A.   +5 more
europepmc   +1 more source

Structural basis for the unique molecular properties of broad-range phospholipase C from Listeria monocytogenes. [PDF]

Nat Commun, 2023
Petrišič N, Adamek M, Kežar A, Hočevar SB, Žagar E, Anderluh G, Podobnik M.   +6 more
europepmc   +1 more source

Platelet‐Activating Factor Pathway in Women With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity

Obesity, EarlyView.
Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...
Joan Duran‐Bertran, Helena Clavero‐Mestres, Razieh Mahmoudian, Sara Muñiz‐Piera, Carmen Aguilar, David Riesco, Javier Camaron, Salomé Martínez, Margarida Vives, Marta París, Fàtima Sabench, Teresa Auguet   +11 more
wiley   +1 more source

Assessment of Expression Levels and Localization Patterns of Phospholipase C zeta in Different Grades of HOST in Human Sperm. [PDF]

Int J Fertil Steril, 2023
Allahveisi A, Yousefian E.
europepmc   +1 more source

In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre‐Clinical Rodent Model

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Amnioinfusions in anhydramnios aim to promote fetal lung development, but currently used fluids (Normal Saline [NS], Lactated Ringer's [LR]) fail to mimic the intrauterine environment and increase reactive oxygen species (ROS). We developed a synthetic amniotic fluid (Amnio‐well, AW) designed to reduce intrauterine ROS.
Braxton Forde, Stephanie Finoti, Marc Oria, Jose L. Peiro   +3 more
wiley   +1 more source

Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease. [PDF]

J Biol Chem, 2023
Chiang YP, Li Z, He M, Jones Q, Pan M, Han X, Jiang XC.   +6 more
europepmc   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C-induced mechanical hypersensitivity. [PDF]

Proc Natl Acad Sci U S A
Tobori S, Tamada K, Uemura N, Sawada K, Kakae M, Nagayasu K, Nakagawa T, Mori Y, Kaneko S, Shirakawa H.   +9 more
europepmc   +1 more source